Controlling water-mediated interactions by designing self-assembled monolayer coatings

Abstract Engineered nanoparticles have been broadly used in biological and geological systems. Hydrophilic molecules such as polyols have been used as coatings on nanoparticle surfaces due to their good biocompatibility and solubility in saline water. However, polyol coatings can cause huge retentio...

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Autores principales:	Hsieh Chen, S. Sherry Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/21db2c8ff2fa4d7e863d8b25d6df77bc
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spelling	oai:doaj.org-article:21db2c8ff2fa4d7e863d8b25d6df77bc2021-12-02T13:44:14ZControlling water-mediated interactions by designing self-assembled monolayer coatings10.1038/s41598-021-87708-82045-2322https://doaj.org/article/21db2c8ff2fa4d7e863d8b25d6df77bc2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87708-8https://doaj.org/toc/2045-2322Abstract Engineered nanoparticles have been broadly used in biological and geological systems. Hydrophilic molecules such as polyols have been used as coatings on nanoparticle surfaces due to their good biocompatibility and solubility in saline water. However, polyol coatings can cause huge retention of nanoparticles when encountering mineral surfaces. Here, molecular dynamics simulations enlightened that the strong adhesion of hydrophilic coatings to mineral surfaces stemming from the partitioning of the hydroxy groups on the hydrophilic molecules to the well-defined bound hydration layers on the mineral surfaces. To mitigate the nanoparticle adhesion, we investigated introducing small percentages of omniphobic fluoroalkanes to form a bicomponent system of hydrophilic and fluoroalkanes, which greatly perturbed the hydration layers on mineral surfaces and resulted in nonstick surface coatings. Our results provide important insight for the design of tunable “stickiness” nanoparticle coatings in different mineralogies, such as applications in subsurface environments or targeted delivery in mineralized tissues.Hsieh ChenS. Sherry ZhuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hsieh Chen S. Sherry Zhu Controlling water-mediated interactions by designing self-assembled monolayer coatings
description	Abstract Engineered nanoparticles have been broadly used in biological and geological systems. Hydrophilic molecules such as polyols have been used as coatings on nanoparticle surfaces due to their good biocompatibility and solubility in saline water. However, polyol coatings can cause huge retention of nanoparticles when encountering mineral surfaces. Here, molecular dynamics simulations enlightened that the strong adhesion of hydrophilic coatings to mineral surfaces stemming from the partitioning of the hydroxy groups on the hydrophilic molecules to the well-defined bound hydration layers on the mineral surfaces. To mitigate the nanoparticle adhesion, we investigated introducing small percentages of omniphobic fluoroalkanes to form a bicomponent system of hydrophilic and fluoroalkanes, which greatly perturbed the hydration layers on mineral surfaces and resulted in nonstick surface coatings. Our results provide important insight for the design of tunable “stickiness” nanoparticle coatings in different mineralogies, such as applications in subsurface environments or targeted delivery in mineralized tissues.
format	article
author	Hsieh Chen S. Sherry Zhu
author_facet	Hsieh Chen S. Sherry Zhu
author_sort	Hsieh Chen
title	Controlling water-mediated interactions by designing self-assembled monolayer coatings
title_short	Controlling water-mediated interactions by designing self-assembled monolayer coatings
title_full	Controlling water-mediated interactions by designing self-assembled monolayer coatings
title_fullStr	Controlling water-mediated interactions by designing self-assembled monolayer coatings
title_full_unstemmed	Controlling water-mediated interactions by designing self-assembled monolayer coatings
title_sort	controlling water-mediated interactions by designing self-assembled monolayer coatings
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/21db2c8ff2fa4d7e863d8b25d6df77bc
work_keys_str_mv	AT hsiehchen controllingwatermediatedinteractionsbydesigningselfassembledmonolayercoatings AT ssherryzhu controllingwatermediatedinteractionsbydesigningselfassembledmonolayercoatings
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Controlling water-mediated interactions by designing self-assembled monolayer coatings

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