Modeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts
The advancement of upper tract urothelial carcinoma (UTUC) research is hampered by the lack of disease-specific models. Here, the authors report patient derived xenograft and cell line models of UTUC, and show that these models retain the genomic and biological heterogeneity of human disease.
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Nature Portfolio
2020
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oai:doaj.org-article:21deaeb5b9144f9aa0be74b0bca108b32021-12-02T17:32:42ZModeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts10.1038/s41467-020-15885-72041-1723https://doaj.org/article/21deaeb5b9144f9aa0be74b0bca108b32020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15885-7https://doaj.org/toc/2041-1723The advancement of upper tract urothelial carcinoma (UTUC) research is hampered by the lack of disease-specific models. Here, the authors report patient derived xenograft and cell line models of UTUC, and show that these models retain the genomic and biological heterogeneity of human disease.Kwanghee KimWenhuo HuFrançois AudenetNima AlmassiAphrothiti J. HanrahanKatie MurrayAditya BagrodiaNathan WongTimothy N. ClintonShawn DasonVishnu MohanSylvia JebiwottKaran NagarJianjiong GaoAlex PensonChris HughesBenjamin GordonZiyu ChenYiyu DongPhilip A. WatsonRicardo AlvimArijh ElzeinSizhi P. GaoEmiliano CoccoAlessandro D. SantinIrina OstrovnayaJames J. HsiehIrit SagiEugene J. PietzakA. Ari HakimiJonathan E. RosenbergGopa IyerHerbert A. VargasMaurizio ScaltritiHikmat Al-AhmadieDavid B. SolitJonathan A. ColemanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020) |
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Science Q Kwanghee Kim Wenhuo Hu François Audenet Nima Almassi Aphrothiti J. Hanrahan Katie Murray Aditya Bagrodia Nathan Wong Timothy N. Clinton Shawn Dason Vishnu Mohan Sylvia Jebiwott Karan Nagar Jianjiong Gao Alex Penson Chris Hughes Benjamin Gordon Ziyu Chen Yiyu Dong Philip A. Watson Ricardo Alvim Arijh Elzein Sizhi P. Gao Emiliano Cocco Alessandro D. Santin Irina Ostrovnaya James J. Hsieh Irit Sagi Eugene J. Pietzak A. Ari Hakimi Jonathan E. Rosenberg Gopa Iyer Herbert A. Vargas Maurizio Scaltriti Hikmat Al-Ahmadie David B. Solit Jonathan A. Coleman Modeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts |
| description |
The advancement of upper tract urothelial carcinoma (UTUC) research is hampered by the lack of disease-specific models. Here, the authors report patient derived xenograft and cell line models of UTUC, and show that these models retain the genomic and biological heterogeneity of human disease. |
| format |
article |
| author |
Kwanghee Kim Wenhuo Hu François Audenet Nima Almassi Aphrothiti J. Hanrahan Katie Murray Aditya Bagrodia Nathan Wong Timothy N. Clinton Shawn Dason Vishnu Mohan Sylvia Jebiwott Karan Nagar Jianjiong Gao Alex Penson Chris Hughes Benjamin Gordon Ziyu Chen Yiyu Dong Philip A. Watson Ricardo Alvim Arijh Elzein Sizhi P. Gao Emiliano Cocco Alessandro D. Santin Irina Ostrovnaya James J. Hsieh Irit Sagi Eugene J. Pietzak A. Ari Hakimi Jonathan E. Rosenberg Gopa Iyer Herbert A. Vargas Maurizio Scaltriti Hikmat Al-Ahmadie David B. Solit Jonathan A. Coleman |
| author_facet |
Kwanghee Kim Wenhuo Hu François Audenet Nima Almassi Aphrothiti J. Hanrahan Katie Murray Aditya Bagrodia Nathan Wong Timothy N. Clinton Shawn Dason Vishnu Mohan Sylvia Jebiwott Karan Nagar Jianjiong Gao Alex Penson Chris Hughes Benjamin Gordon Ziyu Chen Yiyu Dong Philip A. Watson Ricardo Alvim Arijh Elzein Sizhi P. Gao Emiliano Cocco Alessandro D. Santin Irina Ostrovnaya James J. Hsieh Irit Sagi Eugene J. Pietzak A. Ari Hakimi Jonathan E. Rosenberg Gopa Iyer Herbert A. Vargas Maurizio Scaltriti Hikmat Al-Ahmadie David B. Solit Jonathan A. Coleman |
| author_sort |
Kwanghee Kim |
| title |
Modeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts |
| title_short |
Modeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts |
| title_full |
Modeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts |
| title_fullStr |
Modeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts |
| title_full_unstemmed |
Modeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts |
| title_sort |
modeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/21deaeb5b9144f9aa0be74b0bca108b3 |
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