Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration

The small GTPase Rac1 regulates various cellular processes, including cell migration. However, Rac1 can have opposing migratory effects. Here the authors show that two guanine nucleotide exchange factors, Tiam1 and P-Rex1, differentially regulate the Rac1 interactome to determine the downstream phen...

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Autores principales:	Hadir Marei, Alejandro Carpy, Anna Woroniuk, Claire Vennin, Gavin White, Paul Timpson, Boris Macek, Angeliki Malliri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/21df8f4c58ab49ee8a88f25945d57d73
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spelling	oai:doaj.org-article:21df8f4c58ab49ee8a88f25945d57d732021-12-02T16:57:04ZDifferential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration10.1038/ncomms106642041-1723https://doaj.org/article/21df8f4c58ab49ee8a88f25945d57d732016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10664https://doaj.org/toc/2041-1723The small GTPase Rac1 regulates various cellular processes, including cell migration. However, Rac1 can have opposing migratory effects. Here the authors show that two guanine nucleotide exchange factors, Tiam1 and P-Rex1, differentially regulate the Rac1 interactome to determine the downstream phenotype.Hadir MareiAlejandro CarpyAnna WoroniukClaire VenninGavin WhitePaul TimpsonBoris MacekAngeliki MalliriNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hadir Marei Alejandro Carpy Anna Woroniuk Claire Vennin Gavin White Paul Timpson Boris Macek Angeliki Malliri Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration
description	The small GTPase Rac1 regulates various cellular processes, including cell migration. However, Rac1 can have opposing migratory effects. Here the authors show that two guanine nucleotide exchange factors, Tiam1 and P-Rex1, differentially regulate the Rac1 interactome to determine the downstream phenotype.
format	article
author	Hadir Marei Alejandro Carpy Anna Woroniuk Claire Vennin Gavin White Paul Timpson Boris Macek Angeliki Malliri
author_facet	Hadir Marei Alejandro Carpy Anna Woroniuk Claire Vennin Gavin White Paul Timpson Boris Macek Angeliki Malliri
author_sort	Hadir Marei
title	Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration
title_short	Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration
title_full	Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration
title_fullStr	Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration
title_full_unstemmed	Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration
title_sort	differential rac1 signalling by guanine nucleotide exchange factors implicates flii in regulating rac1-driven cell migration
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/21df8f4c58ab49ee8a88f25945d57d73
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Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration

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