Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits

Rare genetic variants can contribute to complex traits but this contribution is not well understood. Here, the authors analyse deep whole genome sequencing data across 1457 individuals from an isolated Greek population and find association of rare variant burdens with cardiometabolic traits.

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Autores principales:	Arthur Gilly, Daniel Suveges, Karoline Kuchenbaecker, Martin Pollard, Lorraine Southam, Konstantinos Hatzikotoulas, Aliki-Eleni Farmaki, Thea Bjornland, Ryan Waples, Emil V. R. Appel, Elisabetta Casalone, Giorgio Melloni, Britt Kilian, Nigel W. Rayner, Ioanna Ntalla, Kousik Kundu, Klaudia Walter, John Danesh, Adam Butterworth, Inês Barroso, Emmanouil Tsafantakis, George Dedoussis, Ida Moltke, Eleftheria Zeggini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/21e7f8a5a81c4b47a35814b4882daaea
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spelling	oai:doaj.org-article:21e7f8a5a81c4b47a35814b4882daaea2021-12-02T16:49:54ZCohort-wide deep whole genome sequencing and the allelic architecture of complex traits10.1038/s41467-018-07070-82041-1723https://doaj.org/article/21e7f8a5a81c4b47a35814b4882daaea2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07070-8https://doaj.org/toc/2041-1723Rare genetic variants can contribute to complex traits but this contribution is not well understood. Here, the authors analyse deep whole genome sequencing data across 1457 individuals from an isolated Greek population and find association of rare variant burdens with cardiometabolic traits.Arthur GillyDaniel SuvegesKaroline KuchenbaeckerMartin PollardLorraine SouthamKonstantinos HatzikotoulasAliki-Eleni FarmakiThea BjornlandRyan WaplesEmil V. R. AppelElisabetta CasaloneGiorgio MelloniBritt KilianNigel W. RaynerIoanna NtallaKousik KunduKlaudia WalterJohn DaneshAdam ButterworthInês BarrosoEmmanouil TsafantakisGeorge DedoussisIda MoltkeEleftheria ZegginiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Arthur Gilly Daniel Suveges Karoline Kuchenbaecker Martin Pollard Lorraine Southam Konstantinos Hatzikotoulas Aliki-Eleni Farmaki Thea Bjornland Ryan Waples Emil V. R. Appel Elisabetta Casalone Giorgio Melloni Britt Kilian Nigel W. Rayner Ioanna Ntalla Kousik Kundu Klaudia Walter John Danesh Adam Butterworth Inês Barroso Emmanouil Tsafantakis George Dedoussis Ida Moltke Eleftheria Zeggini Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits
description	Rare genetic variants can contribute to complex traits but this contribution is not well understood. Here, the authors analyse deep whole genome sequencing data across 1457 individuals from an isolated Greek population and find association of rare variant burdens with cardiometabolic traits.
format	article
author	Arthur Gilly Daniel Suveges Karoline Kuchenbaecker Martin Pollard Lorraine Southam Konstantinos Hatzikotoulas Aliki-Eleni Farmaki Thea Bjornland Ryan Waples Emil V. R. Appel Elisabetta Casalone Giorgio Melloni Britt Kilian Nigel W. Rayner Ioanna Ntalla Kousik Kundu Klaudia Walter John Danesh Adam Butterworth Inês Barroso Emmanouil Tsafantakis George Dedoussis Ida Moltke Eleftheria Zeggini
author_facet	Arthur Gilly Daniel Suveges Karoline Kuchenbaecker Martin Pollard Lorraine Southam Konstantinos Hatzikotoulas Aliki-Eleni Farmaki Thea Bjornland Ryan Waples Emil V. R. Appel Elisabetta Casalone Giorgio Melloni Britt Kilian Nigel W. Rayner Ioanna Ntalla Kousik Kundu Klaudia Walter John Danesh Adam Butterworth Inês Barroso Emmanouil Tsafantakis George Dedoussis Ida Moltke Eleftheria Zeggini
author_sort	Arthur Gilly
title	Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits
title_short	Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits
title_full	Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits
title_fullStr	Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits
title_full_unstemmed	Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits
title_sort	cohort-wide deep whole genome sequencing and the allelic architecture of complex traits
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/21e7f8a5a81c4b47a35814b4882daaea
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Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits

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