Expression changes in pelvic organ prolapse: a systematic review and in silico study

Abstract Pelvic organ prolapse (POP) is a highly disabling condition common for a vast number of women worldwide. To contribute to existing knowledge in POP pathogenesis, we performed a systematic review of expression studies on both specific gene and whole-genome/proteome levels and an in silico an...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Maryam B. Khadzhieva, Dmitry S. Kolobkov, Svetlana V. Kamoeva, Lyubov E. Salnikova
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/21e8d92602404051b5c18bd13883e3e9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:21e8d92602404051b5c18bd13883e3e9
record_format	dspace
spelling	oai:doaj.org-article:21e8d92602404051b5c18bd13883e3e92021-12-02T15:05:43ZExpression changes in pelvic organ prolapse: a systematic review and in silico study10.1038/s41598-017-08185-62045-2322https://doaj.org/article/21e8d92602404051b5c18bd13883e3e92017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08185-6https://doaj.org/toc/2045-2322Abstract Pelvic organ prolapse (POP) is a highly disabling condition common for a vast number of women worldwide. To contribute to existing knowledge in POP pathogenesis, we performed a systematic review of expression studies on both specific gene and whole-genome/proteome levels and an in silico analysis of publicly available datasets related to POP development. The most extensively investigated genes in individual studies were related to extracellular matrix (ECM) organization. Three premenopausal and two postmenopausal sets from two Gene Expression Omnibus (GEO) studies (GSE53868 and GSE12852) were analyzed; Gene Ontology (GO) terms related to tissue repair (locomotion, biological adhesion, immune processes and other) were enriched in all five datasets. Co-expression was higher in cases than in controls in three premenopausal sets. The shared between two or more datasets up-regulated genes were enriched with those related to inflammatory bowel disease (IBD) in the NHGRI GWAS Catalog. ECM-related genes were not over-represented among differently expressed genes. Up-regulation of genes related to tissue renewal probably reflects compensatory mechanisms aimed at repair of damaged tissue. Inefficiency of this process may have different origins including age-related deregulation of gene expression.Maryam B. KhadzhievaDmitry S. KolobkovSvetlana V. KamoevaLyubov E. SalnikovaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maryam B. Khadzhieva Dmitry S. Kolobkov Svetlana V. Kamoeva Lyubov E. Salnikova Expression changes in pelvic organ prolapse: a systematic review and in silico study
description	Abstract Pelvic organ prolapse (POP) is a highly disabling condition common for a vast number of women worldwide. To contribute to existing knowledge in POP pathogenesis, we performed a systematic review of expression studies on both specific gene and whole-genome/proteome levels and an in silico analysis of publicly available datasets related to POP development. The most extensively investigated genes in individual studies were related to extracellular matrix (ECM) organization. Three premenopausal and two postmenopausal sets from two Gene Expression Omnibus (GEO) studies (GSE53868 and GSE12852) were analyzed; Gene Ontology (GO) terms related to tissue repair (locomotion, biological adhesion, immune processes and other) were enriched in all five datasets. Co-expression was higher in cases than in controls in three premenopausal sets. The shared between two or more datasets up-regulated genes were enriched with those related to inflammatory bowel disease (IBD) in the NHGRI GWAS Catalog. ECM-related genes were not over-represented among differently expressed genes. Up-regulation of genes related to tissue renewal probably reflects compensatory mechanisms aimed at repair of damaged tissue. Inefficiency of this process may have different origins including age-related deregulation of gene expression.
format	article
author	Maryam B. Khadzhieva Dmitry S. Kolobkov Svetlana V. Kamoeva Lyubov E. Salnikova
author_facet	Maryam B. Khadzhieva Dmitry S. Kolobkov Svetlana V. Kamoeva Lyubov E. Salnikova
author_sort	Maryam B. Khadzhieva
title	Expression changes in pelvic organ prolapse: a systematic review and in silico study
title_short	Expression changes in pelvic organ prolapse: a systematic review and in silico study
title_full	Expression changes in pelvic organ prolapse: a systematic review and in silico study
title_fullStr	Expression changes in pelvic organ prolapse: a systematic review and in silico study
title_full_unstemmed	Expression changes in pelvic organ prolapse: a systematic review and in silico study
title_sort	expression changes in pelvic organ prolapse: a systematic review and in silico study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/21e8d92602404051b5c18bd13883e3e9
work_keys_str_mv	AT maryambkhadzhieva expressionchangesinpelvicorganprolapseasystematicreviewandinsilicostudy AT dmitryskolobkov expressionchangesinpelvicorganprolapseasystematicreviewandinsilicostudy AT svetlanavkamoeva expressionchangesinpelvicorganprolapseasystematicreviewandinsilicostudy AT lyubovesalnikova expressionchangesinpelvicorganprolapseasystematicreviewandinsilicostudy
_version_	1718388691679838208

Expression changes in pelvic organ prolapse: a systematic review and in silico study

Ejemplares similares