Effect of handgrip on coronary artery disease and myocardial infarction: a Mendelian randomization study

Abstract Observational studies have reported an association of handgrip strength with risk of cardiovascular disease. However, residual confounding and reverse causation may have influenced these findings. A Mendelian randomization (MR) study was conducted to examine whether handgrip is causally ass...

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Autores principales:	Lin Xu, Yuan Tao Hao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/21e96da8ad9a4f48ad76c169745194b8
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spelling	oai:doaj.org-article:21e96da8ad9a4f48ad76c169745194b82021-12-02T16:06:33ZEffect of handgrip on coronary artery disease and myocardial infarction: a Mendelian randomization study10.1038/s41598-017-01073-z2045-2322https://doaj.org/article/21e96da8ad9a4f48ad76c169745194b82017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01073-zhttps://doaj.org/toc/2045-2322Abstract Observational studies have reported an association of handgrip strength with risk of cardiovascular disease. However, residual confounding and reverse causation may have influenced these findings. A Mendelian randomization (MR) study was conducted to examine whether handgrip is causally associated with cardiovascular disease. Two single nucleotide polymorphisms (SNPs), rs3121278 and rs752045, were used as the genetic instruments for handgrip. The effect of each SNP on coronary artery disease/myocardial infarction (CAD/MI) was weighted by its effect on handgrip strength, and estimates were pooled to provide a summary measure for the effect of increased handgrip on risk of CAD/MI. MR analysis showed that higher grip strength reduces risk for CAD/MI, with 1-kilogram increase in genetically determined handgrip reduced odds of CAD by 6% (odds ratio (OR) = 0.94, 95% confidence interval (CI) 0.91–0.99, P = 0.01), and reduced odds of MI by 7% (OR = 0.93, 95% CI 0.89–0.98, P = 0.003). No association of grip strength with type 2 diabetes, body mass index, LDL- and HDL-cholesterol, triglycerides and fasting glucose was found. The inverse causal relationship between handgrip and the risk of CAD or MI suggests that promoting physical activity and resistance training to improve muscle strength may be important for cardiovascular health.Lin XuYuan Tao HaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-5 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lin Xu Yuan Tao Hao Effect of handgrip on coronary artery disease and myocardial infarction: a Mendelian randomization study
description	Abstract Observational studies have reported an association of handgrip strength with risk of cardiovascular disease. However, residual confounding and reverse causation may have influenced these findings. A Mendelian randomization (MR) study was conducted to examine whether handgrip is causally associated with cardiovascular disease. Two single nucleotide polymorphisms (SNPs), rs3121278 and rs752045, were used as the genetic instruments for handgrip. The effect of each SNP on coronary artery disease/myocardial infarction (CAD/MI) was weighted by its effect on handgrip strength, and estimates were pooled to provide a summary measure for the effect of increased handgrip on risk of CAD/MI. MR analysis showed that higher grip strength reduces risk for CAD/MI, with 1-kilogram increase in genetically determined handgrip reduced odds of CAD by 6% (odds ratio (OR) = 0.94, 95% confidence interval (CI) 0.91–0.99, P = 0.01), and reduced odds of MI by 7% (OR = 0.93, 95% CI 0.89–0.98, P = 0.003). No association of grip strength with type 2 diabetes, body mass index, LDL- and HDL-cholesterol, triglycerides and fasting glucose was found. The inverse causal relationship between handgrip and the risk of CAD or MI suggests that promoting physical activity and resistance training to improve muscle strength may be important for cardiovascular health.
format	article
author	Lin Xu Yuan Tao Hao
author_facet	Lin Xu Yuan Tao Hao
author_sort	Lin Xu
title	Effect of handgrip on coronary artery disease and myocardial infarction: a Mendelian randomization study
title_short	Effect of handgrip on coronary artery disease and myocardial infarction: a Mendelian randomization study
title_full	Effect of handgrip on coronary artery disease and myocardial infarction: a Mendelian randomization study
title_fullStr	Effect of handgrip on coronary artery disease and myocardial infarction: a Mendelian randomization study
title_full_unstemmed	Effect of handgrip on coronary artery disease and myocardial infarction: a Mendelian randomization study
title_sort	effect of handgrip on coronary artery disease and myocardial infarction: a mendelian randomization study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/21e96da8ad9a4f48ad76c169745194b8
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Effect of handgrip on coronary artery disease and myocardial infarction: a Mendelian randomization study

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