Chlamydia trachomatis infection induces replication of latent HHV-6.

Human herpesvirus-6 (HHV-6) exists in latent form either as a nuclear episome or integrated into human chromosomes in more than 90% of healthy individuals without causing clinical symptoms. Immunosuppression and stress conditions can reactivate HHV-6 replication, associated with clinical complicatio...

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Autores principales:	Bhupesh K Prusty, Christine Siegl, Petra Hauck, Johannes Hain, Suvi J Korhonen, Eija Hiltunen-Back, Mirja Puolakkainen, Thomas Rudel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/21e995a1cace46be919f043b9a70b922
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spelling	oai:doaj.org-article:21e995a1cace46be919f043b9a70b9222021-11-18T07:48:46ZChlamydia trachomatis infection induces replication of latent HHV-6.1932-620310.1371/journal.pone.0061400https://doaj.org/article/21e995a1cace46be919f043b9a70b9222013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23620749/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Human herpesvirus-6 (HHV-6) exists in latent form either as a nuclear episome or integrated into human chromosomes in more than 90% of healthy individuals without causing clinical symptoms. Immunosuppression and stress conditions can reactivate HHV-6 replication, associated with clinical complications and even death. We have previously shown that co-infection of Chlamydia trachomatis and HHV-6 promotes chlamydial persistence and increases viral uptake in an in vitro cell culture model. Here we investigated C. trachomatis-induced HHV-6 activation in cell lines and fresh blood samples from patients having Chromosomally integrated HHV-6 (CiHHV-6). We observed activation of latent HHV-6 DNA replication in CiHHV-6 cell lines and fresh blood cells without formation of viral particles. Interestingly, we detected HHV-6 DNA in blood as well as cervical swabs from C. trachomatis-infected women. Low virus titers correlated with high C. trachomatis load and vice versa, demonstrating a potentially significant interaction of these pathogens in blood cells and in the cervix of infected patients. Our data suggest a thus far underestimated interference of HHV-6 and C. trachomatis with a likely impact on the disease outcome as consequence of co-infection.Bhupesh K PrustyChristine SieglPetra HauckJohannes HainSuvi J KorhonenEija Hiltunen-BackMirja PuolakkainenThomas RudelPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e61400 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bhupesh K Prusty Christine Siegl Petra Hauck Johannes Hain Suvi J Korhonen Eija Hiltunen-Back Mirja Puolakkainen Thomas Rudel Chlamydia trachomatis infection induces replication of latent HHV-6.
description	Human herpesvirus-6 (HHV-6) exists in latent form either as a nuclear episome or integrated into human chromosomes in more than 90% of healthy individuals without causing clinical symptoms. Immunosuppression and stress conditions can reactivate HHV-6 replication, associated with clinical complications and even death. We have previously shown that co-infection of Chlamydia trachomatis and HHV-6 promotes chlamydial persistence and increases viral uptake in an in vitro cell culture model. Here we investigated C. trachomatis-induced HHV-6 activation in cell lines and fresh blood samples from patients having Chromosomally integrated HHV-6 (CiHHV-6). We observed activation of latent HHV-6 DNA replication in CiHHV-6 cell lines and fresh blood cells without formation of viral particles. Interestingly, we detected HHV-6 DNA in blood as well as cervical swabs from C. trachomatis-infected women. Low virus titers correlated with high C. trachomatis load and vice versa, demonstrating a potentially significant interaction of these pathogens in blood cells and in the cervix of infected patients. Our data suggest a thus far underestimated interference of HHV-6 and C. trachomatis with a likely impact on the disease outcome as consequence of co-infection.
format	article
author	Bhupesh K Prusty Christine Siegl Petra Hauck Johannes Hain Suvi J Korhonen Eija Hiltunen-Back Mirja Puolakkainen Thomas Rudel
author_facet	Bhupesh K Prusty Christine Siegl Petra Hauck Johannes Hain Suvi J Korhonen Eija Hiltunen-Back Mirja Puolakkainen Thomas Rudel
author_sort	Bhupesh K Prusty
title	Chlamydia trachomatis infection induces replication of latent HHV-6.
title_short	Chlamydia trachomatis infection induces replication of latent HHV-6.
title_full	Chlamydia trachomatis infection induces replication of latent HHV-6.
title_fullStr	Chlamydia trachomatis infection induces replication of latent HHV-6.
title_full_unstemmed	Chlamydia trachomatis infection induces replication of latent HHV-6.
title_sort	chlamydia trachomatis infection induces replication of latent hhv-6.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/21e995a1cace46be919f043b9a70b922
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Chlamydia trachomatis infection induces replication of latent HHV-6.

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