Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain

During Drosophila development, two peaks of Notch activity propagate across the neuroepithelium to generate neuroblasts. Here, the authors show Notch cis-inhibition under the control of intracellular Notch trafficking establishes these two peaks, which temporally control neurogenesis in the brain.

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Autores principales:	Miaoxing Wang, Xujun Han, Chuyan Liu, Rie Takayama, Tetsuo Yasugi, Shin-Ichiro Ei, Masaharu Nagayama, Yoshitaro Tanaka, Makoto Sato
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/21ea5b007b2e48b5a7e21e0a8c15e3d0
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spelling	oai:doaj.org-article:21ea5b007b2e48b5a7e21e0a8c15e3d02021-12-02T14:21:20ZIntracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain10.1038/s41467-021-22442-32041-1723https://doaj.org/article/21ea5b007b2e48b5a7e21e0a8c15e3d02021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22442-3https://doaj.org/toc/2041-1723During Drosophila development, two peaks of Notch activity propagate across the neuroepithelium to generate neuroblasts. Here, the authors show Notch cis-inhibition under the control of intracellular Notch trafficking establishes these two peaks, which temporally control neurogenesis in the brain.Miaoxing WangXujun HanChuyan LiuRie TakayamaTetsuo YasugiShin-Ichiro EiMasaharu NagayamaYoshitaro TanakaMakoto SatoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Miaoxing Wang Xujun Han Chuyan Liu Rie Takayama Tetsuo Yasugi Shin-Ichiro Ei Masaharu Nagayama Yoshitaro Tanaka Makoto Sato Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain
description	During Drosophila development, two peaks of Notch activity propagate across the neuroepithelium to generate neuroblasts. Here, the authors show Notch cis-inhibition under the control of intracellular Notch trafficking establishes these two peaks, which temporally control neurogenesis in the brain.
format	article
author	Miaoxing Wang Xujun Han Chuyan Liu Rie Takayama Tetsuo Yasugi Shin-Ichiro Ei Masaharu Nagayama Yoshitaro Tanaka Makoto Sato
author_facet	Miaoxing Wang Xujun Han Chuyan Liu Rie Takayama Tetsuo Yasugi Shin-Ichiro Ei Masaharu Nagayama Yoshitaro Tanaka Makoto Sato
author_sort	Miaoxing Wang
title	Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain
title_short	Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain
title_full	Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain
title_fullStr	Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain
title_full_unstemmed	Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain
title_sort	intracellular trafficking of notch orchestrates temporal dynamics of notch activity in the fly brain
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/21ea5b007b2e48b5a7e21e0a8c15e3d0
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Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain

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