Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain

During Drosophila development, two peaks of Notch activity propagate across the neuroepithelium to generate neuroblasts. Here, the authors show Notch cis-inhibition under the control of intracellular Notch trafficking establishes these two peaks, which temporally control neurogenesis in the brain.

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Bibliographic Details
Main Authors: Miaoxing Wang, Xujun Han, Chuyan Liu, Rie Takayama, Tetsuo Yasugi, Shin-Ichiro Ei, Masaharu Nagayama, Yoshitaro Tanaka, Makoto Sato
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/21ea5b007b2e48b5a7e21e0a8c15e3d0
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