Production of the first effective hyperimmune equine serum antivenom against Africanized bees.

Victims of massive bee attacks become extremely ill, presenting symptoms ranging from dizziness and headache to acute renal failure and multiple organ failure that can lead to death. Previous attempts to develop specific antivenom to treat these victims have been unsuccessful. We herein report a F(a...

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Autores principales:	Keity Souza Santos, Marco Antonio Stephano, José Roberto Marcelino, Virginia Maria Resende Ferreira, Thalita Rocha, Celso Caricati, Hisako Gondo Higashi, Ana Maria Moro, Jorge Elias Kalil, Osmar Malaspina, Fabio Fernandes Morato Castro, Mário Sérgio Palma
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/21ebdf64ffa14cae9fd9718174363e87
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spelling	oai:doaj.org-article:21ebdf64ffa14cae9fd9718174363e872021-11-18T08:46:43ZProduction of the first effective hyperimmune equine serum antivenom against Africanized bees.1932-620310.1371/journal.pone.0079971https://doaj.org/article/21ebdf64ffa14cae9fd9718174363e872013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24236166/?tool=EBIhttps://doaj.org/toc/1932-6203Victims of massive bee attacks become extremely ill, presenting symptoms ranging from dizziness and headache to acute renal failure and multiple organ failure that can lead to death. Previous attempts to develop specific antivenom to treat these victims have been unsuccessful. We herein report a F(ab)(´)(2)-based antivenom raised in horse as a potential new treatment for victims of multiple bee stings. The final product contains high specific IgG titers and is effective in neutralizing toxic effects, such as hemolysis, cytotoxicity and myotoxicity. The assessment of neutralization was revised and hemolysis, the primary toxic effect of these stings, was fully neutralized in vivo for the first time.Keity Souza SantosMarco Antonio StephanoJosé Roberto MarcelinoVirginia Maria Resende FerreiraThalita RochaCelso CaricatiHisako Gondo HigashiAna Maria MoroJorge Elias KalilOsmar MalaspinaFabio Fernandes Morato CastroMário Sérgio PalmaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e79971 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Keity Souza Santos Marco Antonio Stephano José Roberto Marcelino Virginia Maria Resende Ferreira Thalita Rocha Celso Caricati Hisako Gondo Higashi Ana Maria Moro Jorge Elias Kalil Osmar Malaspina Fabio Fernandes Morato Castro Mário Sérgio Palma Production of the first effective hyperimmune equine serum antivenom against Africanized bees.
description	Victims of massive bee attacks become extremely ill, presenting symptoms ranging from dizziness and headache to acute renal failure and multiple organ failure that can lead to death. Previous attempts to develop specific antivenom to treat these victims have been unsuccessful. We herein report a F(ab)(´)(2)-based antivenom raised in horse as a potential new treatment for victims of multiple bee stings. The final product contains high specific IgG titers and is effective in neutralizing toxic effects, such as hemolysis, cytotoxicity and myotoxicity. The assessment of neutralization was revised and hemolysis, the primary toxic effect of these stings, was fully neutralized in vivo for the first time.
format	article
author	Keity Souza Santos Marco Antonio Stephano José Roberto Marcelino Virginia Maria Resende Ferreira Thalita Rocha Celso Caricati Hisako Gondo Higashi Ana Maria Moro Jorge Elias Kalil Osmar Malaspina Fabio Fernandes Morato Castro Mário Sérgio Palma
author_facet	Keity Souza Santos Marco Antonio Stephano José Roberto Marcelino Virginia Maria Resende Ferreira Thalita Rocha Celso Caricati Hisako Gondo Higashi Ana Maria Moro Jorge Elias Kalil Osmar Malaspina Fabio Fernandes Morato Castro Mário Sérgio Palma
author_sort	Keity Souza Santos
title	Production of the first effective hyperimmune equine serum antivenom against Africanized bees.
title_short	Production of the first effective hyperimmune equine serum antivenom against Africanized bees.
title_full	Production of the first effective hyperimmune equine serum antivenom against Africanized bees.
title_fullStr	Production of the first effective hyperimmune equine serum antivenom against Africanized bees.
title_full_unstemmed	Production of the first effective hyperimmune equine serum antivenom against Africanized bees.
title_sort	production of the first effective hyperimmune equine serum antivenom against africanized bees.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/21ebdf64ffa14cae9fd9718174363e87
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Production of the first effective hyperimmune equine serum antivenom against Africanized bees.

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