SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication

Cells deficient in SPRTN protease activity exhibit severe DNA-protein crosslink induced replication stress and genome instability. Here the author reveal a functional link between the SPRTN protease and the CHK1 kinase during physiological DNA replication.

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Autores principales:	Swagata Halder, Ignacio Torrecilla, Martin D. Burkhalter, Marta Popović, John Fielden, Bruno Vaz, Judith Oehler, Domenic Pilger, Davor Lessel, Katherine Wiseman, Abhay Narayan Singh, Iolanda Vendrell, Roman Fischer, Melanie Philipp, Kristijan Ramadan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/21ed31bb8358406db2dcfaaf5eadcf04
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spelling	oai:doaj.org-article:21ed31bb8358406db2dcfaaf5eadcf042021-12-02T16:58:13ZSPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication10.1038/s41467-019-11095-y2041-1723https://doaj.org/article/21ed31bb8358406db2dcfaaf5eadcf042019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11095-yhttps://doaj.org/toc/2041-1723Cells deficient in SPRTN protease activity exhibit severe DNA-protein crosslink induced replication stress and genome instability. Here the author reveal a functional link between the SPRTN protease and the CHK1 kinase during physiological DNA replication.Swagata HalderIgnacio TorrecillaMartin D. BurkhalterMarta PopovićJohn FieldenBruno VazJudith OehlerDomenic PilgerDavor LesselKatherine WisemanAbhay Narayan SinghIolanda VendrellRoman FischerMelanie PhilippKristijan RamadanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Swagata Halder Ignacio Torrecilla Martin D. Burkhalter Marta Popović John Fielden Bruno Vaz Judith Oehler Domenic Pilger Davor Lessel Katherine Wiseman Abhay Narayan Singh Iolanda Vendrell Roman Fischer Melanie Philipp Kristijan Ramadan SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication
description	Cells deficient in SPRTN protease activity exhibit severe DNA-protein crosslink induced replication stress and genome instability. Here the author reveal a functional link between the SPRTN protease and the CHK1 kinase during physiological DNA replication.
format	article
author	Swagata Halder Ignacio Torrecilla Martin D. Burkhalter Marta Popović John Fielden Bruno Vaz Judith Oehler Domenic Pilger Davor Lessel Katherine Wiseman Abhay Narayan Singh Iolanda Vendrell Roman Fischer Melanie Philipp Kristijan Ramadan
author_facet	Swagata Halder Ignacio Torrecilla Martin D. Burkhalter Marta Popović John Fielden Bruno Vaz Judith Oehler Domenic Pilger Davor Lessel Katherine Wiseman Abhay Narayan Singh Iolanda Vendrell Roman Fischer Melanie Philipp Kristijan Ramadan
author_sort	Swagata Halder
title	SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication
title_short	SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication
title_full	SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication
title_fullStr	SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication
title_full_unstemmed	SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication
title_sort	sprtn protease and checkpoint kinase 1 cross-activation loop safeguards dna replication
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/21ed31bb8358406db2dcfaaf5eadcf04
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SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication

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