Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression

Neutrophils normally fulfil their metabolic demands by glycolysis and have limited mitochondrial activity. Here the authors show that tumours promote neutrophils adapted to oxidative mitochondria metabolism that function in the glucose-restrained tumour microenvironment to promote tumour growth by m...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Christopher M. Rice, Luke C. Davies, Jeff J. Subleski, Nunziata Maio, Marieli Gonzalez-Cotto, Caroline Andrews, Nimit L. Patel, Erika M. Palmieri, Jonathan M. Weiss, Jung-Min Lee, Christina M. Annunziata, Tracey A. Rouault, Scott K. Durum, Daniel W. McVicar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/21ee446ffa5a4d17bace3aa38b5d4bbd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:21ee446ffa5a4d17bace3aa38b5d4bbd
record_format	dspace
spelling	oai:doaj.org-article:21ee446ffa5a4d17bace3aa38b5d4bbd2021-12-02T17:32:46ZTumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression10.1038/s41467-018-07505-22041-1723https://doaj.org/article/21ee446ffa5a4d17bace3aa38b5d4bbd2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07505-2https://doaj.org/toc/2041-1723Neutrophils normally fulfil their metabolic demands by glycolysis and have limited mitochondrial activity. Here the authors show that tumours promote neutrophils adapted to oxidative mitochondria metabolism that function in the glucose-restrained tumour microenvironment to promote tumour growth by maintaining local immune suppression.Christopher M. RiceLuke C. DaviesJeff J. SubleskiNunziata MaioMarieli Gonzalez-CottoCaroline AndrewsNimit L. PatelErika M. PalmieriJonathan M. WeissJung-Min LeeChristina M. AnnunziataTracey A. RouaultScott K. DurumDaniel W. McVicarNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christopher M. Rice Luke C. Davies Jeff J. Subleski Nunziata Maio Marieli Gonzalez-Cotto Caroline Andrews Nimit L. Patel Erika M. Palmieri Jonathan M. Weiss Jung-Min Lee Christina M. Annunziata Tracey A. Rouault Scott K. Durum Daniel W. McVicar Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression
description	Neutrophils normally fulfil their metabolic demands by glycolysis and have limited mitochondrial activity. Here the authors show that tumours promote neutrophils adapted to oxidative mitochondria metabolism that function in the glucose-restrained tumour microenvironment to promote tumour growth by maintaining local immune suppression.
format	article
author	Christopher M. Rice Luke C. Davies Jeff J. Subleski Nunziata Maio Marieli Gonzalez-Cotto Caroline Andrews Nimit L. Patel Erika M. Palmieri Jonathan M. Weiss Jung-Min Lee Christina M. Annunziata Tracey A. Rouault Scott K. Durum Daniel W. McVicar
author_facet	Christopher M. Rice Luke C. Davies Jeff J. Subleski Nunziata Maio Marieli Gonzalez-Cotto Caroline Andrews Nimit L. Patel Erika M. Palmieri Jonathan M. Weiss Jung-Min Lee Christina M. Annunziata Tracey A. Rouault Scott K. Durum Daniel W. McVicar
author_sort	Christopher M. Rice
title	Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression
title_short	Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression
title_full	Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression
title_fullStr	Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression
title_full_unstemmed	Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression
title_sort	tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/21ee446ffa5a4d17bace3aa38b5d4bbd
work_keys_str_mv	AT christophermrice tumourelicitedneutrophilsengagemitochondrialmetabolismtocircumventnutrientlimitationsandmaintainimmunesuppression AT lukecdavies tumourelicitedneutrophilsengagemitochondrialmetabolismtocircumventnutrientlimitationsandmaintainimmunesuppression AT jeffjsubleski tumourelicitedneutrophilsengagemitochondrialmetabolismtocircumventnutrientlimitationsandmaintainimmunesuppression AT nunziatamaio tumourelicitedneutrophilsengagemitochondrialmetabolismtocircumventnutrientlimitationsandmaintainimmunesuppression AT marieligonzalezcotto tumourelicitedneutrophilsengagemitochondrialmetabolismtocircumventnutrientlimitationsandmaintainimmunesuppression AT carolineandrews tumourelicitedneutrophilsengagemitochondrialmetabolismtocircumventnutrientlimitationsandmaintainimmunesuppression AT nimitlpatel tumourelicitedneutrophilsengagemitochondrialmetabolismtocircumventnutrientlimitationsandmaintainimmunesuppression AT erikampalmieri tumourelicitedneutrophilsengagemitochondrialmetabolismtocircumventnutrientlimitationsandmaintainimmunesuppression AT jonathanmweiss tumourelicitedneutrophilsengagemitochondrialmetabolismtocircumventnutrientlimitationsandmaintainimmunesuppression AT jungminlee tumourelicitedneutrophilsengagemitochondrialmetabolismtocircumventnutrientlimitationsandmaintainimmunesuppression AT christinamannunziata tumourelicitedneutrophilsengagemitochondrialmetabolismtocircumventnutrientlimitationsandmaintainimmunesuppression AT traceyarouault tumourelicitedneutrophilsengagemitochondrialmetabolismtocircumventnutrientlimitationsandmaintainimmunesuppression AT scottkdurum tumourelicitedneutrophilsengagemitochondrialmetabolismtocircumventnutrientlimitationsandmaintainimmunesuppression AT danielwmcvicar tumourelicitedneutrophilsengagemitochondrialmetabolismtocircumventnutrientlimitationsandmaintainimmunesuppression
_version_	1718380173739425792

Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression

Ejemplares similares