A longitudinal study of pre-pregnancy antioxidant levels and subsequent perinatal outcomes in black and white women: The CARDIA Study.

<h4>Background</h4>Although protective associations between dietary antioxidants and pregnancy outcomes have been reported, randomized controlled trials of supplementation have been almost uniformly negative. A possible explanation is that supplementation during pregnancy may be too late...

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Autores principales:	Emily W Harville, Cora E Lewis, Janet M Catov, David R Jacobs, Myron D Gross, Erica P Gunderson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/21eeeba906a84fcfbca9bd8f48a0aebb
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spelling	oai:doaj.org-article:21eeeba906a84fcfbca9bd8f48a0aebb2021-12-02T20:15:52ZA longitudinal study of pre-pregnancy antioxidant levels and subsequent perinatal outcomes in black and white women: The CARDIA Study.1932-620310.1371/journal.pone.0229002https://doaj.org/article/21eeeba906a84fcfbca9bd8f48a0aebb2020-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0229002https://doaj.org/toc/1932-6203<h4>Background</h4>Although protective associations between dietary antioxidants and pregnancy outcomes have been reported, randomized controlled trials of supplementation have been almost uniformly negative. A possible explanation is that supplementation during pregnancy may be too late to have a beneficial effect. Therefore, we examined the relationship between antioxidant levels prior to pregnancy and birth outcomes.<h4>Methods and findings</h4>Serum carotenoids and tocopherols were assayed in fasting specimens at 1985-86 (baseline) and 1992-1993 (year 7) from 1,215 participants in Coronary Artery Risk Development in Young Adults (CARDIA) study. An interviewer-administered quantitative food-frequency questionnaire assessed dietary intake of antioxidants. Pregnancy outcome was self-reported at exams every 2 to 5 years. Linear and logistic regression modeling was used to assess relationships of low birthweight (LBW; <2,500 g), continuous infant birthweight, preterm birth (PTB; <37 weeks) and length of gestation with antioxidant levels adjusted for confounders, as well as interactions with age and race.<h4>Results</h4>In adjusted models, lycopene was associated with higher odds of LBW (adjusted odds ratio for top quartile, 2.15, 95% confidence interval 1.14, 3.92) and shorter gestational age (adjusted beta coefficient -0.50 weeks). Dietary intake of antioxidants was associated with lower birthweight, while supplement use of vitamin C was associated with higher gestational age (0.41 weeks, 0.01, 0.81).<h4>Conclusions</h4>Higher preconception antioxidant levels are not associated with better birth outcomes.Emily W HarvilleCora E LewisJanet M CatovDavid R JacobsMyron D GrossErica P GundersonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 15, Iss 2, p e0229002 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Emily W Harville Cora E Lewis Janet M Catov David R Jacobs Myron D Gross Erica P Gunderson A longitudinal study of pre-pregnancy antioxidant levels and subsequent perinatal outcomes in black and white women: The CARDIA Study.
description	<h4>Background</h4>Although protective associations between dietary antioxidants and pregnancy outcomes have been reported, randomized controlled trials of supplementation have been almost uniformly negative. A possible explanation is that supplementation during pregnancy may be too late to have a beneficial effect. Therefore, we examined the relationship between antioxidant levels prior to pregnancy and birth outcomes.<h4>Methods and findings</h4>Serum carotenoids and tocopherols were assayed in fasting specimens at 1985-86 (baseline) and 1992-1993 (year 7) from 1,215 participants in Coronary Artery Risk Development in Young Adults (CARDIA) study. An interviewer-administered quantitative food-frequency questionnaire assessed dietary intake of antioxidants. Pregnancy outcome was self-reported at exams every 2 to 5 years. Linear and logistic regression modeling was used to assess relationships of low birthweight (LBW; <2,500 g), continuous infant birthweight, preterm birth (PTB; <37 weeks) and length of gestation with antioxidant levels adjusted for confounders, as well as interactions with age and race.<h4>Results</h4>In adjusted models, lycopene was associated with higher odds of LBW (adjusted odds ratio for top quartile, 2.15, 95% confidence interval 1.14, 3.92) and shorter gestational age (adjusted beta coefficient -0.50 weeks). Dietary intake of antioxidants was associated with lower birthweight, while supplement use of vitamin C was associated with higher gestational age (0.41 weeks, 0.01, 0.81).<h4>Conclusions</h4>Higher preconception antioxidant levels are not associated with better birth outcomes.
format	article
author	Emily W Harville Cora E Lewis Janet M Catov David R Jacobs Myron D Gross Erica P Gunderson
author_facet	Emily W Harville Cora E Lewis Janet M Catov David R Jacobs Myron D Gross Erica P Gunderson
author_sort	Emily W Harville
title	A longitudinal study of pre-pregnancy antioxidant levels and subsequent perinatal outcomes in black and white women: The CARDIA Study.
title_short	A longitudinal study of pre-pregnancy antioxidant levels and subsequent perinatal outcomes in black and white women: The CARDIA Study.
title_full	A longitudinal study of pre-pregnancy antioxidant levels and subsequent perinatal outcomes in black and white women: The CARDIA Study.
title_fullStr	A longitudinal study of pre-pregnancy antioxidant levels and subsequent perinatal outcomes in black and white women: The CARDIA Study.
title_full_unstemmed	A longitudinal study of pre-pregnancy antioxidant levels and subsequent perinatal outcomes in black and white women: The CARDIA Study.
title_sort	longitudinal study of pre-pregnancy antioxidant levels and subsequent perinatal outcomes in black and white women: the cardia study.
publisher	Public Library of Science (PLoS)
publishDate	2020
url	https://doaj.org/article/21eeeba906a84fcfbca9bd8f48a0aebb
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A longitudinal study of pre-pregnancy antioxidant levels and subsequent perinatal outcomes in black and white women: The CARDIA Study.

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