Computational Genomics of Specialized Metabolism: from Natural Product Discovery to Microbiome Ecology

ABSTRACT Microbial and plant specialized metabolites, also known as natural products, are key mediators of microbe-microbe and host-microbe interactions and constitute a rich resource for drug development. In the past decade, genome mining has emerged as a prominent strategy for natural product disc...

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Autor principal:	Marnix H. Medema
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	bioinformatics biosynthetic gene cluster microbiome natural products specialized metabolism Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/21f0e9c8f5004a0e8d814ad8976edbc2
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spelling	oai:doaj.org-article:21f0e9c8f5004a0e8d814ad8976edbc22021-12-02T19:46:20ZComputational Genomics of Specialized Metabolism: from Natural Product Discovery to Microbiome Ecology10.1128/mSystems.00182-172379-5077https://doaj.org/article/21f0e9c8f5004a0e8d814ad8976edbc22018-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00182-17https://doaj.org/toc/2379-5077ABSTRACT Microbial and plant specialized metabolites, also known as natural products, are key mediators of microbe-microbe and host-microbe interactions and constitute a rich resource for drug development. In the past decade, genome mining has emerged as a prominent strategy for natural product discovery. Initially, such mining was performed on the basis of individual microbial genome sequences. Now, these efforts are being scaled up to fully genome-sequenced strain collections, pangenomes of bacterial genera, and large sets of metagenome-assembled genomes from microbial communities. The Medema research group aims to play a leading role in these developments by developing and applying computational approaches to identify, classify, and prioritize specialized metabolite biosynthetic gene clusters and pathways and to connect them to specific molecules and microbiome-associated phenotypes. Moreover, we are extending the scope of genome mining from microbes to plants, which will allow more comprehensive interpretation of the chemical language between hosts and microbes in a microbiome setting.Marnix H. MedemaAmerican Society for Microbiologyarticlebioinformaticsbiosynthetic gene clustermicrobiomenatural productsspecialized metabolismMicrobiologyQR1-502ENmSystems, Vol 3, Iss 2 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	bioinformatics biosynthetic gene cluster microbiome natural products specialized metabolism Microbiology QR1-502
spellingShingle	bioinformatics biosynthetic gene cluster microbiome natural products specialized metabolism Microbiology QR1-502 Marnix H. Medema Computational Genomics of Specialized Metabolism: from Natural Product Discovery to Microbiome Ecology
description	ABSTRACT Microbial and plant specialized metabolites, also known as natural products, are key mediators of microbe-microbe and host-microbe interactions and constitute a rich resource for drug development. In the past decade, genome mining has emerged as a prominent strategy for natural product discovery. Initially, such mining was performed on the basis of individual microbial genome sequences. Now, these efforts are being scaled up to fully genome-sequenced strain collections, pangenomes of bacterial genera, and large sets of metagenome-assembled genomes from microbial communities. The Medema research group aims to play a leading role in these developments by developing and applying computational approaches to identify, classify, and prioritize specialized metabolite biosynthetic gene clusters and pathways and to connect them to specific molecules and microbiome-associated phenotypes. Moreover, we are extending the scope of genome mining from microbes to plants, which will allow more comprehensive interpretation of the chemical language between hosts and microbes in a microbiome setting.
format	article
author	Marnix H. Medema
author_facet	Marnix H. Medema
author_sort	Marnix H. Medema
title	Computational Genomics of Specialized Metabolism: from Natural Product Discovery to Microbiome Ecology
title_short	Computational Genomics of Specialized Metabolism: from Natural Product Discovery to Microbiome Ecology
title_full	Computational Genomics of Specialized Metabolism: from Natural Product Discovery to Microbiome Ecology
title_fullStr	Computational Genomics of Specialized Metabolism: from Natural Product Discovery to Microbiome Ecology
title_full_unstemmed	Computational Genomics of Specialized Metabolism: from Natural Product Discovery to Microbiome Ecology
title_sort	computational genomics of specialized metabolism: from natural product discovery to microbiome ecology
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/21f0e9c8f5004a0e8d814ad8976edbc2
work_keys_str_mv	AT marnixhmedema computationalgenomicsofspecializedmetabolismfromnaturalproductdiscoverytomicrobiomeecology
_version_	1718376013706035200

Computational Genomics of Specialized Metabolism: from Natural Product Discovery to Microbiome Ecology

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