Genome sequencing unveils a regulatory landscape of platelet reactivity
Platelet aggregation is associated with myocardial infarction and stroke. Here, the authors have conducted a whole genome sequencing association study on platelet aggregation, discovering a locus in RGS18, where enhancer assays suggest an effect on activity of haematopoeitic lineage transcription fa...
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Nature Portfolio
2021
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oai:doaj.org-article:21f176ab19b541d294b9acdf21deb0ae2021-12-02T16:04:16ZGenome sequencing unveils a regulatory landscape of platelet reactivity10.1038/s41467-021-23470-92041-1723https://doaj.org/article/21f176ab19b541d294b9acdf21deb0ae2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23470-9https://doaj.org/toc/2041-1723Platelet aggregation is associated with myocardial infarction and stroke. Here, the authors have conducted a whole genome sequencing association study on platelet aggregation, discovering a locus in RGS18, where enhancer assays suggest an effect on activity of haematopoeitic lineage transcription factors.Ali R. KeramatiMing-Huei ChenBenjamin A. T. RodriguezLisa R. YanekArunoday BhanBrady J. GaynorKathleen RyanJennifer A. BrodyXue ZhongQiang WeiNHLBI Trans-Omics for Precision (TOPMed) ConsortiumKai KammersKanika KanchanKruthika IyerMadeline H. KowalskiAchilleas N. PitsillidesL. Adrienne CupplesBingshan LiThorsten M. SchlaegerAlan R. ShuldinerJeffrey R. O’ConnellIngo RuczinskiBraxton D. MitchellNauder FaradayMargaret A. TaubLewis C. BeckerJoshua P. LewisRasika A. MathiasAndrew D. JohnsonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Ali R. Keramati Ming-Huei Chen Benjamin A. T. Rodriguez Lisa R. Yanek Arunoday Bhan Brady J. Gaynor Kathleen Ryan Jennifer A. Brody Xue Zhong Qiang Wei NHLBI Trans-Omics for Precision (TOPMed) Consortium Kai Kammers Kanika Kanchan Kruthika Iyer Madeline H. Kowalski Achilleas N. Pitsillides L. Adrienne Cupples Bingshan Li Thorsten M. Schlaeger Alan R. Shuldiner Jeffrey R. O’Connell Ingo Ruczinski Braxton D. Mitchell Nauder Faraday Margaret A. Taub Lewis C. Becker Joshua P. Lewis Rasika A. Mathias Andrew D. Johnson Genome sequencing unveils a regulatory landscape of platelet reactivity |
| description |
Platelet aggregation is associated with myocardial infarction and stroke. Here, the authors have conducted a whole genome sequencing association study on platelet aggregation, discovering a locus in RGS18, where enhancer assays suggest an effect on activity of haematopoeitic lineage transcription factors. |
| format |
article |
| author |
Ali R. Keramati Ming-Huei Chen Benjamin A. T. Rodriguez Lisa R. Yanek Arunoday Bhan Brady J. Gaynor Kathleen Ryan Jennifer A. Brody Xue Zhong Qiang Wei NHLBI Trans-Omics for Precision (TOPMed) Consortium Kai Kammers Kanika Kanchan Kruthika Iyer Madeline H. Kowalski Achilleas N. Pitsillides L. Adrienne Cupples Bingshan Li Thorsten M. Schlaeger Alan R. Shuldiner Jeffrey R. O’Connell Ingo Ruczinski Braxton D. Mitchell Nauder Faraday Margaret A. Taub Lewis C. Becker Joshua P. Lewis Rasika A. Mathias Andrew D. Johnson |
| author_facet |
Ali R. Keramati Ming-Huei Chen Benjamin A. T. Rodriguez Lisa R. Yanek Arunoday Bhan Brady J. Gaynor Kathleen Ryan Jennifer A. Brody Xue Zhong Qiang Wei NHLBI Trans-Omics for Precision (TOPMed) Consortium Kai Kammers Kanika Kanchan Kruthika Iyer Madeline H. Kowalski Achilleas N. Pitsillides L. Adrienne Cupples Bingshan Li Thorsten M. Schlaeger Alan R. Shuldiner Jeffrey R. O’Connell Ingo Ruczinski Braxton D. Mitchell Nauder Faraday Margaret A. Taub Lewis C. Becker Joshua P. Lewis Rasika A. Mathias Andrew D. Johnson |
| author_sort |
Ali R. Keramati |
| title |
Genome sequencing unveils a regulatory landscape of platelet reactivity |
| title_short |
Genome sequencing unveils a regulatory landscape of platelet reactivity |
| title_full |
Genome sequencing unveils a regulatory landscape of platelet reactivity |
| title_fullStr |
Genome sequencing unveils a regulatory landscape of platelet reactivity |
| title_full_unstemmed |
Genome sequencing unveils a regulatory landscape of platelet reactivity |
| title_sort |
genome sequencing unveils a regulatory landscape of platelet reactivity |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/21f176ab19b541d294b9acdf21deb0ae |
| work_keys_str_mv |
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