Isolation, analysis and in vitro assessment of CYP3A4 inhibition by methylxanthines extracted from Pu-erh and Bancha tea leaves

Abstract Methylxanthines, purine alkaloids found in plants, are found in beverages (coffee, tea, cocoa) and foods (chocolate and other cocoa-containing foods) commonly consumed worldwide. Members of this family include caffeine, theophylline and theobromine. Methylxanthines have a variety of pharmac...

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Autores principales:	Kaloyan D. Georgiev, Maya Radeva-Ilieva, Stanila Stoeva, Iliya Zhelev
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/21f466d8945f41b4b2e85610fef08cb8
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spelling	oai:doaj.org-article:21f466d8945f41b4b2e85610fef08cb82021-12-02T15:10:01ZIsolation, analysis and in vitro assessment of CYP3A4 inhibition by methylxanthines extracted from Pu-erh and Bancha tea leaves10.1038/s41598-019-50468-72045-2322https://doaj.org/article/21f466d8945f41b4b2e85610fef08cb82019-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-50468-7https://doaj.org/toc/2045-2322Abstract Methylxanthines, purine alkaloids found in plants, are found in beverages (coffee, tea, cocoa) and foods (chocolate and other cocoa-containing foods) commonly consumed worldwide. Members of this family include caffeine, theophylline and theobromine. Methylxanthines have a variety of pharmacological effects, and caffeine and theophylline are used as pharmaceuticals. Methylxanthines are metabolized in the liver predominantly by the enzyme CYP1A2. Their co-administration with CYP1A2 inhibitors may lead to pharmacokinetic interactions. Little is known about the possible drug interactions between caffeine and substrates of other CYP450 enzymes. In our study, methylxanthine fractions inhibited CYP3A4 in a concentration-dependent manner. Concomitant consumption of green tea with CYP3A4 substrates could increase the possibility of interactions, and this requires further clarification. The inhibition of CYP3A4 is not only due to the presence of catechin derivatives but methylxanthines may also contribute to this effect.Kaloyan D. GeorgievMaya Radeva-IlievaStanila StoevaIliya ZhelevNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kaloyan D. Georgiev Maya Radeva-Ilieva Stanila Stoeva Iliya Zhelev Isolation, analysis and in vitro assessment of CYP3A4 inhibition by methylxanthines extracted from Pu-erh and Bancha tea leaves
description	Abstract Methylxanthines, purine alkaloids found in plants, are found in beverages (coffee, tea, cocoa) and foods (chocolate and other cocoa-containing foods) commonly consumed worldwide. Members of this family include caffeine, theophylline and theobromine. Methylxanthines have a variety of pharmacological effects, and caffeine and theophylline are used as pharmaceuticals. Methylxanthines are metabolized in the liver predominantly by the enzyme CYP1A2. Their co-administration with CYP1A2 inhibitors may lead to pharmacokinetic interactions. Little is known about the possible drug interactions between caffeine and substrates of other CYP450 enzymes. In our study, methylxanthine fractions inhibited CYP3A4 in a concentration-dependent manner. Concomitant consumption of green tea with CYP3A4 substrates could increase the possibility of interactions, and this requires further clarification. The inhibition of CYP3A4 is not only due to the presence of catechin derivatives but methylxanthines may also contribute to this effect.
format	article
author	Kaloyan D. Georgiev Maya Radeva-Ilieva Stanila Stoeva Iliya Zhelev
author_facet	Kaloyan D. Georgiev Maya Radeva-Ilieva Stanila Stoeva Iliya Zhelev
author_sort	Kaloyan D. Georgiev
title	Isolation, analysis and in vitro assessment of CYP3A4 inhibition by methylxanthines extracted from Pu-erh and Bancha tea leaves
title_short	Isolation, analysis and in vitro assessment of CYP3A4 inhibition by methylxanthines extracted from Pu-erh and Bancha tea leaves
title_full	Isolation, analysis and in vitro assessment of CYP3A4 inhibition by methylxanthines extracted from Pu-erh and Bancha tea leaves
title_fullStr	Isolation, analysis and in vitro assessment of CYP3A4 inhibition by methylxanthines extracted from Pu-erh and Bancha tea leaves
title_full_unstemmed	Isolation, analysis and in vitro assessment of CYP3A4 inhibition by methylxanthines extracted from Pu-erh and Bancha tea leaves
title_sort	isolation, analysis and in vitro assessment of cyp3a4 inhibition by methylxanthines extracted from pu-erh and bancha tea leaves
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/21f466d8945f41b4b2e85610fef08cb8
work_keys_str_mv	AT kaloyandgeorgiev isolationanalysisandinvitroassessmentofcyp3a4inhibitionbymethylxanthinesextractedfrompuerhandbanchatealeaves AT mayaradevailieva isolationanalysisandinvitroassessmentofcyp3a4inhibitionbymethylxanthinesextractedfrompuerhandbanchatealeaves AT stanilastoeva isolationanalysisandinvitroassessmentofcyp3a4inhibitionbymethylxanthinesextractedfrompuerhandbanchatealeaves AT iliyazhelev isolationanalysisandinvitroassessmentofcyp3a4inhibitionbymethylxanthinesextractedfrompuerhandbanchatealeaves
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Isolation, analysis and in vitro assessment of CYP3A4 inhibition by methylxanthines extracted from Pu-erh and Bancha tea leaves

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