Spatiotemporal beam self-cleaning for high-resolution nonlinear fluorescence imaging with multimode fiber
Abstract Beam self-cleaning (BSC) in graded-index (GRIN) multimode fibers (MMFs) has been recently reported by different research groups. Driven by the interplay between Kerr effect and beam self-imaging, BSC counteracts random mode coupling, and forces laser beams to recover a quasi-single mode pro...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/21f7cc9048ee47b488c22f18a0b5640e |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:21f7cc9048ee47b488c22f18a0b5640e |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:21f7cc9048ee47b488c22f18a0b5640e2021-12-02T18:34:01ZSpatiotemporal beam self-cleaning for high-resolution nonlinear fluorescence imaging with multimode fiber10.1038/s41598-021-96753-22045-2322https://doaj.org/article/21f7cc9048ee47b488c22f18a0b5640e2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96753-2https://doaj.org/toc/2045-2322Abstract Beam self-cleaning (BSC) in graded-index (GRIN) multimode fibers (MMFs) has been recently reported by different research groups. Driven by the interplay between Kerr effect and beam self-imaging, BSC counteracts random mode coupling, and forces laser beams to recover a quasi-single mode profile at the output of GRIN fibers. Here we show that the associated self-induced spatiotemporal reshaping allows for improving the performances of nonlinear fluorescence (NF) microscopy and endoscopy using multimode optical fibers. We experimentally demonstrate that the beam brightness increase, induced by self-cleaning, enables two and three-photon imaging of biological samples with high spatial resolution. Temporal pulse shortening accompanying spatial beam clean-up enhances the output peak power, hence the efficiency of nonlinear imaging. We also show that spatiotemporal supercontinuum (SC) generation is well-suited for large-band NF imaging in visible and infrared domains. We substantiated our findings by multiphoton fluorescence imaging in both microscopy and endoscopy configurations.Nawell Ould MoussaTigran MansuryanCharles-Henri HageMarc FabertKatarzyna KrupaAlessandro TonelloMario FerraroLuca LeggioMario ZitelliFabio ManginiAlioune NiangGuy MillotMassimiliano PapiStefan WabnitzVincent CoudercNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Nawell Ould Moussa Tigran Mansuryan Charles-Henri Hage Marc Fabert Katarzyna Krupa Alessandro Tonello Mario Ferraro Luca Leggio Mario Zitelli Fabio Mangini Alioune Niang Guy Millot Massimiliano Papi Stefan Wabnitz Vincent Couderc Spatiotemporal beam self-cleaning for high-resolution nonlinear fluorescence imaging with multimode fiber |
| description |
Abstract Beam self-cleaning (BSC) in graded-index (GRIN) multimode fibers (MMFs) has been recently reported by different research groups. Driven by the interplay between Kerr effect and beam self-imaging, BSC counteracts random mode coupling, and forces laser beams to recover a quasi-single mode profile at the output of GRIN fibers. Here we show that the associated self-induced spatiotemporal reshaping allows for improving the performances of nonlinear fluorescence (NF) microscopy and endoscopy using multimode optical fibers. We experimentally demonstrate that the beam brightness increase, induced by self-cleaning, enables two and three-photon imaging of biological samples with high spatial resolution. Temporal pulse shortening accompanying spatial beam clean-up enhances the output peak power, hence the efficiency of nonlinear imaging. We also show that spatiotemporal supercontinuum (SC) generation is well-suited for large-band NF imaging in visible and infrared domains. We substantiated our findings by multiphoton fluorescence imaging in both microscopy and endoscopy configurations. |
| format |
article |
| author |
Nawell Ould Moussa Tigran Mansuryan Charles-Henri Hage Marc Fabert Katarzyna Krupa Alessandro Tonello Mario Ferraro Luca Leggio Mario Zitelli Fabio Mangini Alioune Niang Guy Millot Massimiliano Papi Stefan Wabnitz Vincent Couderc |
| author_facet |
Nawell Ould Moussa Tigran Mansuryan Charles-Henri Hage Marc Fabert Katarzyna Krupa Alessandro Tonello Mario Ferraro Luca Leggio Mario Zitelli Fabio Mangini Alioune Niang Guy Millot Massimiliano Papi Stefan Wabnitz Vincent Couderc |
| author_sort |
Nawell Ould Moussa |
| title |
Spatiotemporal beam self-cleaning for high-resolution nonlinear fluorescence imaging with multimode fiber |
| title_short |
Spatiotemporal beam self-cleaning for high-resolution nonlinear fluorescence imaging with multimode fiber |
| title_full |
Spatiotemporal beam self-cleaning for high-resolution nonlinear fluorescence imaging with multimode fiber |
| title_fullStr |
Spatiotemporal beam self-cleaning for high-resolution nonlinear fluorescence imaging with multimode fiber |
| title_full_unstemmed |
Spatiotemporal beam self-cleaning for high-resolution nonlinear fluorescence imaging with multimode fiber |
| title_sort |
spatiotemporal beam self-cleaning for high-resolution nonlinear fluorescence imaging with multimode fiber |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/21f7cc9048ee47b488c22f18a0b5640e |
| work_keys_str_mv |
AT nawellouldmoussa spatiotemporalbeamselfcleaningforhighresolutionnonlinearfluorescenceimagingwithmultimodefiber AT tigranmansuryan spatiotemporalbeamselfcleaningforhighresolutionnonlinearfluorescenceimagingwithmultimodefiber AT charleshenrihage spatiotemporalbeamselfcleaningforhighresolutionnonlinearfluorescenceimagingwithmultimodefiber AT marcfabert spatiotemporalbeamselfcleaningforhighresolutionnonlinearfluorescenceimagingwithmultimodefiber AT katarzynakrupa spatiotemporalbeamselfcleaningforhighresolutionnonlinearfluorescenceimagingwithmultimodefiber AT alessandrotonello spatiotemporalbeamselfcleaningforhighresolutionnonlinearfluorescenceimagingwithmultimodefiber AT marioferraro spatiotemporalbeamselfcleaningforhighresolutionnonlinearfluorescenceimagingwithmultimodefiber AT lucaleggio spatiotemporalbeamselfcleaningforhighresolutionnonlinearfluorescenceimagingwithmultimodefiber AT mariozitelli spatiotemporalbeamselfcleaningforhighresolutionnonlinearfluorescenceimagingwithmultimodefiber AT fabiomangini spatiotemporalbeamselfcleaningforhighresolutionnonlinearfluorescenceimagingwithmultimodefiber AT aliouneniang spatiotemporalbeamselfcleaningforhighresolutionnonlinearfluorescenceimagingwithmultimodefiber AT guymillot spatiotemporalbeamselfcleaningforhighresolutionnonlinearfluorescenceimagingwithmultimodefiber AT massimilianopapi spatiotemporalbeamselfcleaningforhighresolutionnonlinearfluorescenceimagingwithmultimodefiber AT stefanwabnitz spatiotemporalbeamselfcleaningforhighresolutionnonlinearfluorescenceimagingwithmultimodefiber AT vincentcouderc spatiotemporalbeamselfcleaningforhighresolutionnonlinearfluorescenceimagingwithmultimodefiber |
| _version_ |
1718377906555584512 |