Prevalence of hypovitaminosis D in COVID-19 patients in the intensive care unit

Background: The prevalence of hypovitaminosis D has not been studied in the Russian Federation for the group of patients with severe and extremely severe COVID-19 in the intensive care unit (ICU). Aims: To study the prevalence of hypovitaminosis D in patients with COVID-19 treated in the ICU and to...

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Autores principales:	Mikhail V. Bychinin, Irina A. Mandel’, Tatiana V. Klypa, Nadezhda A. Kolyshkina, Sergei A. Andreichenko
Formato:	article
Lenguaje:	RU
Publicado:	Eco-vector 2021
Materias:	covid-19 vitamin d deficiency mortality intensive care and intensive care Medicine R
Acceso en línea:	https://doaj.org/article/21fdc7a58c1342f1921e5fa14ea9c70d
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spelling	oai:doaj.org-article:21fdc7a58c1342f1921e5fa14ea9c70d2021-11-30T18:15:21ZPrevalence of hypovitaminosis D in COVID-19 patients in the intensive care unit2220-30952618-862710.17816/clinpract64976https://doaj.org/article/21fdc7a58c1342f1921e5fa14ea9c70d2021-03-01T00:00:00Zhttps://journals.eco-vector.com/clinpractice/article/viewFile/64976/pdfhttps://doaj.org/toc/2220-3095https://doaj.org/toc/2618-8627Background: The prevalence of hypovitaminosis D has not been studied in the Russian Federation for the group of patients with severe and extremely severe COVID-19 in the intensive care unit (ICU). Aims: To study the prevalence of hypovitaminosis D in patients with COVID-19 treated in the ICU and to determine the relationship between the vitamin D status and disease outcome. Methods: The retrospective study included 103 adult patients with severe and extremely severe COVID-19 hospitalized in the ICU. Results: 94% patients (n = 97) showed a significant decrease in the concentration of 25 (OH) D in their blood serum 11 ng/ml [7; 15 ng/ml]. 37% (n = 38) of patients showed vitamin D deficiency, 46% (n = 47) had severe vitamin D deficiency, 12% (n = 12) had vitamin D insufficiency, 5% (n = 6) had normal vitamin D levels. In the group of patients with vitamin D levels less than 10 ng/ml, the mortality rate was significantly higher than that in the group of patients with the levels of vitamin D exceeding 10 ng/ml (66% and 42%, p = 0.018). These two groups of patients also significantly differed in their age (p = 0.018), history of diabetes mellitus (p = 0.059), white blood cell count (p = 0.045), neutrophil to lymphocyte ratio (p = 0.017), D-dimer level (p = 0.05) and troponin T level (p = 0.054). Conclusion: A high incidence of vitamin D insufficiency in patients with COVID-19 treated in the ICU has been identified. Severe vitamin D deficiency was more often found in elderly patients with diabetes mellitus, and was associated with the increased mortality. The identified relationship of the vitamin D deficiency with the neutrophilic-lymphocytic index suggests an immuno-mediated effect on the outcome of patients with COVID-19.Mikhail V. BychininIrina A. Mandel’Tatiana V. KlypaNadezhda A. KolyshkinaSergei A. AndreichenkoEco-vectorarticlecovid-19vitamin d deficiencymortalityintensive care and intensive careMedicineRRUКлиническая практика , Vol 12, Iss 1, Pp 25-32 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	covid-19 vitamin d deficiency mortality intensive care and intensive care Medicine R
spellingShingle	covid-19 vitamin d deficiency mortality intensive care and intensive care Medicine R Mikhail V. Bychinin Irina A. Mandel’ Tatiana V. Klypa Nadezhda A. Kolyshkina Sergei A. Andreichenko Prevalence of hypovitaminosis D in COVID-19 patients in the intensive care unit
description	Background: The prevalence of hypovitaminosis D has not been studied in the Russian Federation for the group of patients with severe and extremely severe COVID-19 in the intensive care unit (ICU). Aims: To study the prevalence of hypovitaminosis D in patients with COVID-19 treated in the ICU and to determine the relationship between the vitamin D status and disease outcome. Methods: The retrospective study included 103 adult patients with severe and extremely severe COVID-19 hospitalized in the ICU. Results: 94% patients (n = 97) showed a significant decrease in the concentration of 25 (OH) D in their blood serum 11 ng/ml [7; 15 ng/ml]. 37% (n = 38) of patients showed vitamin D deficiency, 46% (n = 47) had severe vitamin D deficiency, 12% (n = 12) had vitamin D insufficiency, 5% (n = 6) had normal vitamin D levels. In the group of patients with vitamin D levels less than 10 ng/ml, the mortality rate was significantly higher than that in the group of patients with the levels of vitamin D exceeding 10 ng/ml (66% and 42%, p = 0.018). These two groups of patients also significantly differed in their age (p = 0.018), history of diabetes mellitus (p = 0.059), white blood cell count (p = 0.045), neutrophil to lymphocyte ratio (p = 0.017), D-dimer level (p = 0.05) and troponin T level (p = 0.054). Conclusion: A high incidence of vitamin D insufficiency in patients with COVID-19 treated in the ICU has been identified. Severe vitamin D deficiency was more often found in elderly patients with diabetes mellitus, and was associated with the increased mortality. The identified relationship of the vitamin D deficiency with the neutrophilic-lymphocytic index suggests an immuno-mediated effect on the outcome of patients with COVID-19.
format	article
author	Mikhail V. Bychinin Irina A. Mandel’ Tatiana V. Klypa Nadezhda A. Kolyshkina Sergei A. Andreichenko
author_facet	Mikhail V. Bychinin Irina A. Mandel’ Tatiana V. Klypa Nadezhda A. Kolyshkina Sergei A. Andreichenko
author_sort	Mikhail V. Bychinin
title	Prevalence of hypovitaminosis D in COVID-19 patients in the intensive care unit
title_short	Prevalence of hypovitaminosis D in COVID-19 patients in the intensive care unit
title_full	Prevalence of hypovitaminosis D in COVID-19 patients in the intensive care unit
title_fullStr	Prevalence of hypovitaminosis D in COVID-19 patients in the intensive care unit
title_full_unstemmed	Prevalence of hypovitaminosis D in COVID-19 patients in the intensive care unit
title_sort	prevalence of hypovitaminosis d in covid-19 patients in the intensive care unit
publisher	Eco-vector
publishDate	2021
url	https://doaj.org/article/21fdc7a58c1342f1921e5fa14ea9c70d
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Prevalence of hypovitaminosis D in COVID-19 patients in the intensive care unit

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