Relationship between occult hepatitis B virus infection and chronic kidney disease in a Chinese population-based cohort

Objective: Previous studies have revealed inconsistent results regarding the association between occult hepatitis B virus (HBV) infection and chronic kidney disease (CKD). Therefore, we conducted a prospective cohort study to evaluate the association between occult HBV infection and CKD. Methods: A...

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Autores principales:	Xiang-Lei Kong, Xiao-Jing Ma, Hong Su, Dong-Mei Xu
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2016
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/220025e877cc42e7a1cec24b76c73324
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spelling	oai:doaj.org-article:220025e877cc42e7a1cec24b76c733242021-12-02T13:42:26ZRelationship between occult hepatitis B virus infection and chronic kidney disease in a Chinese population-based cohort2095-882X10.1016/j.cdtm.2016.07.001https://doaj.org/article/220025e877cc42e7a1cec24b76c733242016-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X16300287https://doaj.org/toc/2095-882XObjective: Previous studies have revealed inconsistent results regarding the association between occult hepatitis B virus (HBV) infection and chronic kidney disease (CKD). Therefore, we conducted a prospective cohort study to evaluate the association between occult HBV infection and CKD. Methods: A total of 4329 adults, aged 46.2Â Â±Â 13.7 years, without CKD at baseline were enrolled while undergoing physical examinations. Occult HBV infection was defined as seropositivity for antibody to HBV core antigen. CKD was defined as decreased estimated glomerular filtration rate (eGFRÂ <Â 60Â mlÂ·minâ1Â·1.73Â mâ2) or presence of proteinuria â¥1+, assessed using a repeated dipstick method. eGFR was computed using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Results: The prevalence of occult HBV infection was 8.1% (352/4329). During 5 years of follow-up, 165 patients (3.8%) developed CKD. Univariate Logistic regression analysis showed that occult HBV infection was positively associated with decreased eGFR, with an odds ratio (OR) of 2.15 (95% confidence interval (CI): 1.05â4.11). In contrast, occult HBV infection was not associated with either proteinuria or CKD (PÂ >Â 0.05). After adjustment for potential confounders in the multivariate Logistic regression analysis, age, hypertension, diabetes, and the highest quartile of uric acid were associated with CKD, with ORs of 1.04 (95% CI: 1.02â1.05), 2.1 (95% CI: 1.46â3.01), 2.02 (95% CI: 1.36â2.99), and 1.86 (95% CI: 1.17â2.95), respectively. However, occult HBV infection was not associated with CKD, with an OR of 1.12 (95% CI: 0.65â1.95). Conclusions: This study did not find an association between occult HBV infection and CKD. However, high-risk patients infected with HBV should still be targeted for monitoring for the development of CKD. Keywords: Chronic kidney disease, Proteinuria, Estimated glomerular filtration rate, Hepatitis B virusXiang-Lei KongXiao-Jing MaHong SuDong-Mei XuKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 2, Iss 1, Pp 55-60 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Xiang-Lei Kong Xiao-Jing Ma Hong Su Dong-Mei Xu Relationship between occult hepatitis B virus infection and chronic kidney disease in a Chinese population-based cohort
description	Objective: Previous studies have revealed inconsistent results regarding the association between occult hepatitis B virus (HBV) infection and chronic kidney disease (CKD). Therefore, we conducted a prospective cohort study to evaluate the association between occult HBV infection and CKD. Methods: A total of 4329 adults, aged 46.2Â Â±Â 13.7 years, without CKD at baseline were enrolled while undergoing physical examinations. Occult HBV infection was defined as seropositivity for antibody to HBV core antigen. CKD was defined as decreased estimated glomerular filtration rate (eGFRÂ <Â 60Â mlÂ·minâ1Â·1.73Â mâ2) or presence of proteinuria â¥1+, assessed using a repeated dipstick method. eGFR was computed using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Results: The prevalence of occult HBV infection was 8.1% (352/4329). During 5 years of follow-up, 165 patients (3.8%) developed CKD. Univariate Logistic regression analysis showed that occult HBV infection was positively associated with decreased eGFR, with an odds ratio (OR) of 2.15 (95% confidence interval (CI): 1.05â4.11). In contrast, occult HBV infection was not associated with either proteinuria or CKD (PÂ >Â 0.05). After adjustment for potential confounders in the multivariate Logistic regression analysis, age, hypertension, diabetes, and the highest quartile of uric acid were associated with CKD, with ORs of 1.04 (95% CI: 1.02â1.05), 2.1 (95% CI: 1.46â3.01), 2.02 (95% CI: 1.36â2.99), and 1.86 (95% CI: 1.17â2.95), respectively. However, occult HBV infection was not associated with CKD, with an OR of 1.12 (95% CI: 0.65â1.95). Conclusions: This study did not find an association between occult HBV infection and CKD. However, high-risk patients infected with HBV should still be targeted for monitoring for the development of CKD. Keywords: Chronic kidney disease, Proteinuria, Estimated glomerular filtration rate, Hepatitis B virus
format	article
author	Xiang-Lei Kong Xiao-Jing Ma Hong Su Dong-Mei Xu
author_facet	Xiang-Lei Kong Xiao-Jing Ma Hong Su Dong-Mei Xu
author_sort	Xiang-Lei Kong
title	Relationship between occult hepatitis B virus infection and chronic kidney disease in a Chinese population-based cohort
title_short	Relationship between occult hepatitis B virus infection and chronic kidney disease in a Chinese population-based cohort
title_full	Relationship between occult hepatitis B virus infection and chronic kidney disease in a Chinese population-based cohort
title_fullStr	Relationship between occult hepatitis B virus infection and chronic kidney disease in a Chinese population-based cohort
title_full_unstemmed	Relationship between occult hepatitis B virus infection and chronic kidney disease in a Chinese population-based cohort
title_sort	relationship between occult hepatitis b virus infection and chronic kidney disease in a chinese population-based cohort
publisher	KeAi Communications Co., Ltd.
publishDate	2016
url	https://doaj.org/article/220025e877cc42e7a1cec24b76c73324
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Relationship between occult hepatitis B virus infection and chronic kidney disease in a Chinese population-based cohort

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