A systematic approach to the development of a safe live attenuated Zika vaccine

A systematic approach to the development of a safe live attenuated Zika vaccine

A Zika virus (ZIKV) vaccine should provide long-lasting immunity, which may be achieved with a live-attenuated vaccine. Here, Kwek et al. select an interferon-restricted, attenuated ZIKV variant and evaluate replication and immunogenicity in mouse and mosquito models.

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Autores principales: Swee Sen Kwek, Satoru Watanabe, Kuan Rong Chan, Eugenia Z. Ong, Hwee Cheng Tan, Wy Ching Ng, Mien T. X. Nguyen, Esther S. Gan, Summer L. Zhang, Kitti W. K. Chan, Jun Hao Tan, October M. Sessions, Menchie Manuel, Julien Pompon, Camillus Chua, Sharifah Hazirah, Karl Tryggvason, Subhash G. Vasudevan, Eng Eong Ooi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/2200a4c3d0464f52b6e961470788a10a
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spelling oai:doaj.org-article:2200a4c3d0464f52b6e961470788a10a2021-12-02T15:33:44ZA systematic approach to the development of a safe live attenuated Zika vaccine10.1038/s41467-018-03337-22041-1723https://doaj.org/article/2200a4c3d0464f52b6e961470788a10a2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03337-2https://doaj.org/toc/2041-1723A Zika virus (ZIKV) vaccine should provide long-lasting immunity, which may be achieved with a live-attenuated vaccine. Here, Kwek et al. select an interferon-restricted, attenuated ZIKV variant and evaluate replication and immunogenicity in mouse and mosquito models.Swee Sen KwekSatoru WatanabeKuan Rong ChanEugenia Z. OngHwee Cheng TanWy Ching NgMien T. X. NguyenEsther S. GanSummer L. ZhangKitti W. K. ChanJun Hao TanOctober M. SessionsMenchie ManuelJulien PomponCamillus ChuaSharifah HazirahKarl TryggvasonSubhash G. VasudevanEng Eong OoiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Swee Sen Kwek
Satoru Watanabe
Kuan Rong Chan
Eugenia Z. Ong
Hwee Cheng Tan
Wy Ching Ng
Mien T. X. Nguyen
Esther S. Gan
Summer L. Zhang
Kitti W. K. Chan
Jun Hao Tan
October M. Sessions
Menchie Manuel
Julien Pompon
Camillus Chua
Sharifah Hazirah
Karl Tryggvason
Subhash G. Vasudevan
Eng Eong Ooi
A systematic approach to the development of a safe live attenuated Zika vaccine
description A Zika virus (ZIKV) vaccine should provide long-lasting immunity, which may be achieved with a live-attenuated vaccine. Here, Kwek et al. select an interferon-restricted, attenuated ZIKV variant and evaluate replication and immunogenicity in mouse and mosquito models.
format article
author Swee Sen Kwek
Satoru Watanabe
Kuan Rong Chan
Eugenia Z. Ong
Hwee Cheng Tan
Wy Ching Ng
Mien T. X. Nguyen
Esther S. Gan
Summer L. Zhang
Kitti W. K. Chan
Jun Hao Tan
October M. Sessions
Menchie Manuel
Julien Pompon
Camillus Chua
Sharifah Hazirah
Karl Tryggvason
Subhash G. Vasudevan
Eng Eong Ooi
author_facet Swee Sen Kwek
Satoru Watanabe
Kuan Rong Chan
Eugenia Z. Ong
Hwee Cheng Tan
Wy Ching Ng
Mien T. X. Nguyen
Esther S. Gan
Summer L. Zhang
Kitti W. K. Chan
Jun Hao Tan
October M. Sessions
Menchie Manuel
Julien Pompon
Camillus Chua
Sharifah Hazirah
Karl Tryggvason
Subhash G. Vasudevan
Eng Eong Ooi
author_sort Swee Sen Kwek
title A systematic approach to the development of a safe live attenuated Zika vaccine
title_short A systematic approach to the development of a safe live attenuated Zika vaccine
title_full A systematic approach to the development of a safe live attenuated Zika vaccine
title_fullStr A systematic approach to the development of a safe live attenuated Zika vaccine
title_full_unstemmed A systematic approach to the development of a safe live attenuated Zika vaccine
title_sort systematic approach to the development of a safe live attenuated zika vaccine
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/2200a4c3d0464f52b6e961470788a10a
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