Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor

SARS-CoV-2 spike protein binds host ACE2 for virus entry. Here, the authors determine kinetic and thermodynamic properties of this interaction using atomic force microscopy, develop peptides that inhibit binding and suggest existence of additional attachment factors.

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Autores principales:	Jinsung Yang, Simon J. L. Petitjean, Melanie Koehler, Qingrong Zhang, Andra C. Dumitru, Wenzhang Chen, Sylvie Derclaye, Stéphane P. Vincent, Patrice Soumillion, David Alsteens
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/22063247702e4aba8bea199d3422791c
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spelling	oai:doaj.org-article:22063247702e4aba8bea199d3422791c2021-12-02T17:19:41ZMolecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor10.1038/s41467-020-18319-62041-1723https://doaj.org/article/22063247702e4aba8bea199d3422791c2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18319-6https://doaj.org/toc/2041-1723SARS-CoV-2 spike protein binds host ACE2 for virus entry. Here, the authors determine kinetic and thermodynamic properties of this interaction using atomic force microscopy, develop peptides that inhibit binding and suggest existence of additional attachment factors.Jinsung YangSimon J. L. PetitjeanMelanie KoehlerQingrong ZhangAndra C. DumitruWenzhang ChenSylvie DerclayeStéphane P. VincentPatrice SoumillionDavid AlsteensNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jinsung Yang Simon J. L. Petitjean Melanie Koehler Qingrong Zhang Andra C. Dumitru Wenzhang Chen Sylvie Derclaye Stéphane P. Vincent Patrice Soumillion David Alsteens Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor
description	SARS-CoV-2 spike protein binds host ACE2 for virus entry. Here, the authors determine kinetic and thermodynamic properties of this interaction using atomic force microscopy, develop peptides that inhibit binding and suggest existence of additional attachment factors.
format	article
author	Jinsung Yang Simon J. L. Petitjean Melanie Koehler Qingrong Zhang Andra C. Dumitru Wenzhang Chen Sylvie Derclaye Stéphane P. Vincent Patrice Soumillion David Alsteens
author_facet	Jinsung Yang Simon J. L. Petitjean Melanie Koehler Qingrong Zhang Andra C. Dumitru Wenzhang Chen Sylvie Derclaye Stéphane P. Vincent Patrice Soumillion David Alsteens
author_sort	Jinsung Yang
title	Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor
title_short	Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor
title_full	Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor
title_fullStr	Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor
title_full_unstemmed	Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor
title_sort	molecular interaction and inhibition of sars-cov-2 binding to the ace2 receptor
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/22063247702e4aba8bea199d3422791c
work_keys_str_mv	AT jinsungyang molecularinteractionandinhibitionofsarscov2bindingtotheace2receptor AT simonjlpetitjean molecularinteractionandinhibitionofsarscov2bindingtotheace2receptor AT melaniekoehler molecularinteractionandinhibitionofsarscov2bindingtotheace2receptor AT qingrongzhang molecularinteractionandinhibitionofsarscov2bindingtotheace2receptor AT andracdumitru molecularinteractionandinhibitionofsarscov2bindingtotheace2receptor AT wenzhangchen molecularinteractionandinhibitionofsarscov2bindingtotheace2receptor AT sylviederclaye molecularinteractionandinhibitionofsarscov2bindingtotheace2receptor AT stephanepvincent molecularinteractionandinhibitionofsarscov2bindingtotheace2receptor AT patricesoumillion molecularinteractionandinhibitionofsarscov2bindingtotheace2receptor AT davidalsteens molecularinteractionandinhibitionofsarscov2bindingtotheace2receptor
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Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor

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