The Hippo Signaling Pathway: The Trader of Tumor Microenvironment

The Hippo pathway regulates cancer biology in many aspects and the crosstalk with other pathways complicates its role. Accumulated evidence has shown that the bidirectional interactions between tumor cells and tumor microenvironment (TME) are the premises of tumor occurrence, development, and metast...

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Autores principales:	Duo Yang, Na Zhang, Meihua Li, Tao Hong, Wei Meng, Taohui Ouyang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Hippo pathway cancer molecular network immune modulation microenvironment Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/220a59fcf2d74267a62cb66c00ccf0b0
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id	oai:doaj.org-article:220a59fcf2d74267a62cb66c00ccf0b0
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spelling	oai:doaj.org-article:220a59fcf2d74267a62cb66c00ccf0b02021-11-11T10:22:48ZThe Hippo Signaling Pathway: The Trader of Tumor Microenvironment2234-943X10.3389/fonc.2021.772134https://doaj.org/article/220a59fcf2d74267a62cb66c00ccf0b02021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.772134/fullhttps://doaj.org/toc/2234-943XThe Hippo pathway regulates cancer biology in many aspects and the crosstalk with other pathways complicates its role. Accumulated evidence has shown that the bidirectional interactions between tumor cells and tumor microenvironment (TME) are the premises of tumor occurrence, development, and metastasis. The relationship among different components of the TME constitutes a three-dimensional network. We point out the core position of the Hippo pathway in this network and discuss how the regulatory inputs cause the chain reaction of the network. We also discuss the important role of Hippo-TME involvement in cancer treatment.Duo YangNa ZhangMeihua LiTao HongWei MengTaohui OuyangFrontiers Media S.A.articleHippo pathwaycancermolecular networkimmune modulationmicroenvironmentNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hippo pathway cancer molecular network immune modulation microenvironment Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Hippo pathway cancer molecular network immune modulation microenvironment Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Duo Yang Na Zhang Meihua Li Tao Hong Wei Meng Taohui Ouyang The Hippo Signaling Pathway: The Trader of Tumor Microenvironment
description	The Hippo pathway regulates cancer biology in many aspects and the crosstalk with other pathways complicates its role. Accumulated evidence has shown that the bidirectional interactions between tumor cells and tumor microenvironment (TME) are the premises of tumor occurrence, development, and metastasis. The relationship among different components of the TME constitutes a three-dimensional network. We point out the core position of the Hippo pathway in this network and discuss how the regulatory inputs cause the chain reaction of the network. We also discuss the important role of Hippo-TME involvement in cancer treatment.
format	article
author	Duo Yang Na Zhang Meihua Li Tao Hong Wei Meng Taohui Ouyang
author_facet	Duo Yang Na Zhang Meihua Li Tao Hong Wei Meng Taohui Ouyang
author_sort	Duo Yang
title	The Hippo Signaling Pathway: The Trader of Tumor Microenvironment
title_short	The Hippo Signaling Pathway: The Trader of Tumor Microenvironment
title_full	The Hippo Signaling Pathway: The Trader of Tumor Microenvironment
title_fullStr	The Hippo Signaling Pathway: The Trader of Tumor Microenvironment
title_full_unstemmed	The Hippo Signaling Pathway: The Trader of Tumor Microenvironment
title_sort	hippo signaling pathway: the trader of tumor microenvironment
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/220a59fcf2d74267a62cb66c00ccf0b0
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The Hippo Signaling Pathway: The Trader of Tumor Microenvironment

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