Circulating sex hormones in relation to anthropometric, sociodemographic and behavioural factors in an international dataset of 12,300 men.

<h4>Introduction</h4>Sex hormones have been implicated in the etiology of a number of diseases. To better understand disease etiology and the mechanisms of disease-risk factor associations, this analysis aimed to investigate the associations of anthropometric, sociodemographic and behavi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Eleanor L Watts, Paul N Appleby, Demetrius Albanes, Amanda Black, June M Chan, Chu Chen, Piera M Cirillo, Barbara A Cohn, Michael B Cook, Jenny L Donovan, Luigi Ferrucci, Cedric F Garland, Graham G Giles, Phyllis J Goodman, Laurel A Habel, Christopher A Haiman, Jeff M P Holly, Robert N Hoover, Rudolf Kaaks, Paul Knekt, Laurence N Kolonel, Tatsuhiko Kubo, Loïc Le Marchand, Tapio Luostarinen, Robert J MacInnis, Hanna O Mäenpää, Satu Männistö, E Jeffrey Metter, Roger L Milne, Abraham M Y Nomura, Steven E Oliver, J Kellogg Parsons, Petra H Peeters, Elizabeth A Platz, Elio Riboli, Fulvio Ricceri, Sabina Rinaldi, Harri Rissanen, Norie Sawada, Catherine A Schaefer, Jeannette M Schenk, Frank Z Stanczyk, Meir Stampfer, Pär Stattin, Ulf-Håkan Stenman, Anne Tjønneland, Antonia Trichopoulou, Ian M Thompson, Shoichiro Tsugane, Lars Vatten, Alice S Whittemore, Regina G Ziegler, Naomi E Allen, Timothy J Key, Ruth C Travis
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/220b20dddc614ed5b5cb7519e7c7fb1c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:220b20dddc614ed5b5cb7519e7c7fb1c
record_format	dspace
spelling	oai:doaj.org-article:220b20dddc614ed5b5cb7519e7c7fb1c2021-12-02T20:05:48ZCirculating sex hormones in relation to anthropometric, sociodemographic and behavioural factors in an international dataset of 12,300 men.1932-620310.1371/journal.pone.0187741https://doaj.org/article/220b20dddc614ed5b5cb7519e7c7fb1c2017-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0187741https://doaj.org/toc/1932-6203<h4>Introduction</h4>Sex hormones have been implicated in the etiology of a number of diseases. To better understand disease etiology and the mechanisms of disease-risk factor associations, this analysis aimed to investigate the associations of anthropometric, sociodemographic and behavioural factors with a range of circulating sex hormones and sex hormone-binding globulin.<h4>Methods</h4>Statistical analyses of individual participant data from 12,330 male controls aged 25-85 years from 25 studies involved in the Endogenous Hormones Nutritional Biomarkers and Prostate Cancer Collaborative Group. Analysis of variance was used to estimate geometric means adjusted for study and relevant covariates.<h4>Results</h4>Older age was associated with higher concentrations of sex hormone-binding globulin and dihydrotestosterone and lower concentrations of dehydroepiandrosterone sulfate, free testosterone, androstenedione, androstanediol glucuronide and free estradiol. Higher body mass index was associated with higher concentrations of free estradiol, androstanediol glucuronide, estradiol and estrone and lower concentrations of dihydrotestosterone, testosterone, sex hormone-binding globulin, free testosterone, androstenedione and dehydroepiandrosterone sulfate. Taller height was associated with lower concentrations of androstenedione, testosterone, free testosterone and sex hormone-binding globulin and higher concentrations of androstanediol glucuronide. Current smoking was associated with higher concentrations of androstenedione, sex hormone-binding globulin and testosterone. Alcohol consumption was associated with higher concentrations of dehydroepiandrosterone sulfate, androstenedione and androstanediol glucuronide. East Asians had lower concentrations of androstanediol glucuronide and African Americans had higher concentrations of estrogens. Education and marital status were modestly associated with a small number of hormones.<h4>Conclusion</h4>Circulating sex hormones in men are strongly associated with age and body mass index, and to a lesser extent with smoking status and alcohol consumption.Eleanor L WattsPaul N ApplebyDemetrius AlbanesAmanda BlackJune M ChanChu ChenPiera M CirilloBarbara A CohnMichael B CookJenny L DonovanLuigi FerrucciCedric F GarlandGraham G GilesPhyllis J GoodmanLaurel A HabelChristopher A HaimanJeff M P HollyRobert N HooverRudolf KaaksPaul KnektLaurence N KolonelTatsuhiko KuboLoïc Le MarchandTapio LuostarinenRobert J MacInnisHanna O MäenpääSatu MännistöE Jeffrey MetterRoger L MilneAbraham M Y NomuraSteven E OliverJ Kellogg ParsonsPetra H PeetersElizabeth A PlatzElio RiboliFulvio RicceriSabina RinaldiHarri RissanenNorie SawadaCatherine A SchaeferJeannette M SchenkFrank Z StanczykMeir StampferPär StattinUlf-Håkan StenmanAnne TjønnelandAntonia TrichopoulouIan M ThompsonShoichiro TsuganeLars VattenAlice S WhittemoreRegina G ZieglerNaomi E AllenTimothy J KeyRuth C TravisPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 12, Iss 12, p e0187741 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eleanor L Watts Paul N Appleby Demetrius Albanes Amanda Black June M Chan Chu Chen Piera M Cirillo Barbara A Cohn Michael B Cook Jenny L Donovan Luigi Ferrucci Cedric F Garland Graham G Giles Phyllis J Goodman Laurel A Habel Christopher A Haiman Jeff M P Holly Robert N Hoover Rudolf Kaaks Paul Knekt Laurence N Kolonel Tatsuhiko Kubo Loïc Le Marchand Tapio Luostarinen Robert J MacInnis Hanna O Mäenpää Satu Männistö E Jeffrey Metter Roger L Milne Abraham M Y Nomura Steven E Oliver J Kellogg Parsons Petra H Peeters Elizabeth A Platz Elio Riboli Fulvio Ricceri Sabina Rinaldi Harri Rissanen Norie Sawada Catherine A Schaefer Jeannette M Schenk Frank Z Stanczyk Meir Stampfer Pär Stattin Ulf-Håkan Stenman Anne Tjønneland Antonia Trichopoulou Ian M Thompson Shoichiro Tsugane Lars Vatten Alice S Whittemore Regina G Ziegler Naomi E Allen Timothy J Key Ruth C Travis Circulating sex hormones in relation to anthropometric, sociodemographic and behavioural factors in an international dataset of 12,300 men.
description	<h4>Introduction</h4>Sex hormones have been implicated in the etiology of a number of diseases. To better understand disease etiology and the mechanisms of disease-risk factor associations, this analysis aimed to investigate the associations of anthropometric, sociodemographic and behavioural factors with a range of circulating sex hormones and sex hormone-binding globulin.<h4>Methods</h4>Statistical analyses of individual participant data from 12,330 male controls aged 25-85 years from 25 studies involved in the Endogenous Hormones Nutritional Biomarkers and Prostate Cancer Collaborative Group. Analysis of variance was used to estimate geometric means adjusted for study and relevant covariates.<h4>Results</h4>Older age was associated with higher concentrations of sex hormone-binding globulin and dihydrotestosterone and lower concentrations of dehydroepiandrosterone sulfate, free testosterone, androstenedione, androstanediol glucuronide and free estradiol. Higher body mass index was associated with higher concentrations of free estradiol, androstanediol glucuronide, estradiol and estrone and lower concentrations of dihydrotestosterone, testosterone, sex hormone-binding globulin, free testosterone, androstenedione and dehydroepiandrosterone sulfate. Taller height was associated with lower concentrations of androstenedione, testosterone, free testosterone and sex hormone-binding globulin and higher concentrations of androstanediol glucuronide. Current smoking was associated with higher concentrations of androstenedione, sex hormone-binding globulin and testosterone. Alcohol consumption was associated with higher concentrations of dehydroepiandrosterone sulfate, androstenedione and androstanediol glucuronide. East Asians had lower concentrations of androstanediol glucuronide and African Americans had higher concentrations of estrogens. Education and marital status were modestly associated with a small number of hormones.<h4>Conclusion</h4>Circulating sex hormones in men are strongly associated with age and body mass index, and to a lesser extent with smoking status and alcohol consumption.
format	article
author	Eleanor L Watts Paul N Appleby Demetrius Albanes Amanda Black June M Chan Chu Chen Piera M Cirillo Barbara A Cohn Michael B Cook Jenny L Donovan Luigi Ferrucci Cedric F Garland Graham G Giles Phyllis J Goodman Laurel A Habel Christopher A Haiman Jeff M P Holly Robert N Hoover Rudolf Kaaks Paul Knekt Laurence N Kolonel Tatsuhiko Kubo Loïc Le Marchand Tapio Luostarinen Robert J MacInnis Hanna O Mäenpää Satu Männistö E Jeffrey Metter Roger L Milne Abraham M Y Nomura Steven E Oliver J Kellogg Parsons Petra H Peeters Elizabeth A Platz Elio Riboli Fulvio Ricceri Sabina Rinaldi Harri Rissanen Norie Sawada Catherine A Schaefer Jeannette M Schenk Frank Z Stanczyk Meir Stampfer Pär Stattin Ulf-Håkan Stenman Anne Tjønneland Antonia Trichopoulou Ian M Thompson Shoichiro Tsugane Lars Vatten Alice S Whittemore Regina G Ziegler Naomi E Allen Timothy J Key Ruth C Travis
author_facet	Eleanor L Watts Paul N Appleby Demetrius Albanes Amanda Black June M Chan Chu Chen Piera M Cirillo Barbara A Cohn Michael B Cook Jenny L Donovan Luigi Ferrucci Cedric F Garland Graham G Giles Phyllis J Goodman Laurel A Habel Christopher A Haiman Jeff M P Holly Robert N Hoover Rudolf Kaaks Paul Knekt Laurence N Kolonel Tatsuhiko Kubo Loïc Le Marchand Tapio Luostarinen Robert J MacInnis Hanna O Mäenpää Satu Männistö E Jeffrey Metter Roger L Milne Abraham M Y Nomura Steven E Oliver J Kellogg Parsons Petra H Peeters Elizabeth A Platz Elio Riboli Fulvio Ricceri Sabina Rinaldi Harri Rissanen Norie Sawada Catherine A Schaefer Jeannette M Schenk Frank Z Stanczyk Meir Stampfer Pär Stattin Ulf-Håkan Stenman Anne Tjønneland Antonia Trichopoulou Ian M Thompson Shoichiro Tsugane Lars Vatten Alice S Whittemore Regina G Ziegler Naomi E Allen Timothy J Key Ruth C Travis
author_sort	Eleanor L Watts
title	Circulating sex hormones in relation to anthropometric, sociodemographic and behavioural factors in an international dataset of 12,300 men.
title_short	Circulating sex hormones in relation to anthropometric, sociodemographic and behavioural factors in an international dataset of 12,300 men.
title_full	Circulating sex hormones in relation to anthropometric, sociodemographic and behavioural factors in an international dataset of 12,300 men.
title_fullStr	Circulating sex hormones in relation to anthropometric, sociodemographic and behavioural factors in an international dataset of 12,300 men.
title_full_unstemmed	Circulating sex hormones in relation to anthropometric, sociodemographic and behavioural factors in an international dataset of 12,300 men.
title_sort	circulating sex hormones in relation to anthropometric, sociodemographic and behavioural factors in an international dataset of 12,300 men.
publisher	Public Library of Science (PLoS)
publishDate	2017
url	https://doaj.org/article/220b20dddc614ed5b5cb7519e7c7fb1c
work_keys_str_mv	AT eleanorlwatts circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT paulnappleby circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT demetriusalbanes circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT amandablack circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT junemchan circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT chuchen circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT pieramcirillo circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT barbaraacohn circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT michaelbcook circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT jennyldonovan circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT luigiferrucci circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT cedricfgarland circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT grahamggiles circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT phyllisjgoodman circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT laurelahabel circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT christopherahaiman circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT jeffmpholly circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT robertnhoover circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT rudolfkaaks circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT paulknekt circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT laurencenkolonel circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT tatsuhikokubo circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT loiclemarchand circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT tapioluostarinen circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT robertjmacinnis circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT hannaomaenpaa circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT satumannisto circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT ejeffreymetter circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT rogerlmilne circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT abrahammynomura circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT steveneoliver circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT jkelloggparsons circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT petrahpeeters circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT elizabethaplatz circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT elioriboli circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT fulvioricceri circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT sabinarinaldi circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT harririssanen circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT noriesawada circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT catherineaschaefer circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT jeannettemschenk circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT frankzstanczyk circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT meirstampfer circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT parstattin circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT ulfhakanstenman circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT annetjønneland circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT antoniatrichopoulou circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT ianmthompson circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT shoichirotsugane circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT larsvatten circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT aliceswhittemore circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT reginagziegler circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT naomieallen circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT timothyjkey circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men AT ruthctravis circulatingsexhormonesinrelationtoanthropometricsociodemographicandbehaviouralfactorsinaninternationaldatasetof12300men
_version_	1718375408897884160

Circulating sex hormones in relation to anthropometric, sociodemographic and behavioural factors in an international dataset of 12,300 men.

Ejemplares similares