Study of hydrocellular functional material as microbicidal wound dressing for diabetic wound healing

A hydrocellular functional material as a wound dressing is developed and it is found to be superior in its efficacy as compared to some of the comparator controls in diabetic wound healing studies. A study on wound contraction and Histopathological analysis is done in rats. The efficacy of the dress...

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Autores principales:	Michael Rodrigues, Thilagavati Govindharajan
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/220dd19517374704a444deb404610c5e
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spelling	oai:doaj.org-article:220dd19517374704a444deb404610c5e2021-12-01T02:03:51ZStudy of hydrocellular functional material as microbicidal wound dressing for diabetic wound healing2280-800010.1177/22808000211054930https://doaj.org/article/220dd19517374704a444deb404610c5e2021-11-01T00:00:00Zhttps://doi.org/10.1177/22808000211054930https://doaj.org/toc/2280-8000A hydrocellular functional material as a wound dressing is developed and it is found to be superior in its efficacy as compared to some of the comparator controls in diabetic wound healing studies. A study on wound contraction and Histopathological analysis is done in rats. The efficacy of the dressing is comparable to the established wound dressings like Carboxymethyl cellulose alginate dressings and autolytic enzyme based hydrogel. It is found to be superior to Polyhexamethylene biguanide dressing used as reference controls in this study. The reason for good wound healing performance of the dressing can be attributed to a combined property of effective exudates management and broad spectrum antimicrobial effect. The concept of functional hydro cellular material has shown good results due to the excellent balance of exudates pickup and drying it out. This ensures moist wound healing conditions on the wound. Because of its porous nature it allows good air flow and gaseous exchange in the structure. The cationic sites created on the surface of the dressing ensure a good antimicrobial action on the exudates in the dressing. It reduces the infection load on the wound. The nonleaching property of the dressing also helps in preventing the generation of more resistant and mutant strains of the microbes. The developed dressing can be used as a relatively durable long lasting dressing for wound management in diabetic wounds. The need of repetitive wound dressing changes can be brought down with this concept of dressing. It is not only cost effective in terms of its material cost but also is a cost effective solution when entire wound management cost is considered. Such novel wound dressing material can change the quality of life of diabetic wound patients especially in developing world, where access to functional advanced wound care dressings is limited.Michael RodriguesThilagavati GovindharajanSAGE PublishingarticleBiotechnologyTP248.13-248.65ENJournal of Applied Biomaterials & Functional Materials, Vol 19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biotechnology TP248.13-248.65
spellingShingle	Biotechnology TP248.13-248.65 Michael Rodrigues Thilagavati Govindharajan Study of hydrocellular functional material as microbicidal wound dressing for diabetic wound healing
description	A hydrocellular functional material as a wound dressing is developed and it is found to be superior in its efficacy as compared to some of the comparator controls in diabetic wound healing studies. A study on wound contraction and Histopathological analysis is done in rats. The efficacy of the dressing is comparable to the established wound dressings like Carboxymethyl cellulose alginate dressings and autolytic enzyme based hydrogel. It is found to be superior to Polyhexamethylene biguanide dressing used as reference controls in this study. The reason for good wound healing performance of the dressing can be attributed to a combined property of effective exudates management and broad spectrum antimicrobial effect. The concept of functional hydro cellular material has shown good results due to the excellent balance of exudates pickup and drying it out. This ensures moist wound healing conditions on the wound. Because of its porous nature it allows good air flow and gaseous exchange in the structure. The cationic sites created on the surface of the dressing ensure a good antimicrobial action on the exudates in the dressing. It reduces the infection load on the wound. The nonleaching property of the dressing also helps in preventing the generation of more resistant and mutant strains of the microbes. The developed dressing can be used as a relatively durable long lasting dressing for wound management in diabetic wounds. The need of repetitive wound dressing changes can be brought down with this concept of dressing. It is not only cost effective in terms of its material cost but also is a cost effective solution when entire wound management cost is considered. Such novel wound dressing material can change the quality of life of diabetic wound patients especially in developing world, where access to functional advanced wound care dressings is limited.
format	article
author	Michael Rodrigues Thilagavati Govindharajan
author_facet	Michael Rodrigues Thilagavati Govindharajan
author_sort	Michael Rodrigues
title	Study of hydrocellular functional material as microbicidal wound dressing for diabetic wound healing
title_short	Study of hydrocellular functional material as microbicidal wound dressing for diabetic wound healing
title_full	Study of hydrocellular functional material as microbicidal wound dressing for diabetic wound healing
title_fullStr	Study of hydrocellular functional material as microbicidal wound dressing for diabetic wound healing
title_full_unstemmed	Study of hydrocellular functional material as microbicidal wound dressing for diabetic wound healing
title_sort	study of hydrocellular functional material as microbicidal wound dressing for diabetic wound healing
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/220dd19517374704a444deb404610c5e
work_keys_str_mv	AT michaelrodrigues studyofhydrocellularfunctionalmaterialasmicrobicidalwounddressingfordiabeticwoundhealing AT thilagavatigovindharajan studyofhydrocellularfunctionalmaterialasmicrobicidalwounddressingfordiabeticwoundhealing
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Study of hydrocellular functional material as microbicidal wound dressing for diabetic wound healing

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