High Mobility Group Box 1 Protein Level as a Novel Biomarker for the Development of Peri-Implant Disease

Abstract Peri-implant disease is a chronic inflammation of the soft and hard tissues around a dental implant, resulting from bacterial infection. Recent evidence indicates that some pro-inflammatory cytokines and chemokines released by immunocytes are substantially responsible for the progress and c...

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Autores principales:	Jinpan Liu, Ronghui Li, Tongjun Liu, Xiaohui Rausch-Fan, Mingguo Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/220edb951a344c0b9414564a6824448f
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spelling	oai:doaj.org-article:220edb951a344c0b9414564a6824448f2021-12-02T15:06:12ZHigh Mobility Group Box 1 Protein Level as a Novel Biomarker for the Development of Peri-Implant Disease10.1038/s41598-017-06937-y2045-2322https://doaj.org/article/220edb951a344c0b9414564a6824448f2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06937-yhttps://doaj.org/toc/2045-2322Abstract Peri-implant disease is a chronic inflammation of the soft and hard tissues around a dental implant, resulting from bacterial infection. Recent evidence indicates that some pro-inflammatory cytokines and chemokines released by immunocytes are substantially responsible for the progress and consequence of inflammation. High mobility group box 1 (HMGB1) is released into the extracellular matrix and acts as a key pro-inflammatory factor during injury, necrosis and inflammation. A higher concentration of HMGB1 has been found in gingival crevicular fluid from inflammatory gingival tissue than from healthy sites. HMGB1 mRNA and protein are overexpressed in murine periodontal ligament fibroblasts stimulated with lipopolysaccharide (LPS) and IL-1β. Thus, this study sought to assess HMGB1 expression in peri-implant crevicular fluid (PICF) at each stage of peri-implant disease and to investigate the correlation between HMGB1 and peri-implant disease progress. The results demonstrated that the HMGB1 expression level in PICF is indicative of the progress of peri-implant disease and hence may be a useful diagnostic and prognostic biomarker for peri-implant tissue.Jinpan LiuRonghui LiTongjun LiuXiaohui Rausch-FanMingguo WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jinpan Liu Ronghui Li Tongjun Liu Xiaohui Rausch-Fan Mingguo Wang High Mobility Group Box 1 Protein Level as a Novel Biomarker for the Development of Peri-Implant Disease
description	Abstract Peri-implant disease is a chronic inflammation of the soft and hard tissues around a dental implant, resulting from bacterial infection. Recent evidence indicates that some pro-inflammatory cytokines and chemokines released by immunocytes are substantially responsible for the progress and consequence of inflammation. High mobility group box 1 (HMGB1) is released into the extracellular matrix and acts as a key pro-inflammatory factor during injury, necrosis and inflammation. A higher concentration of HMGB1 has been found in gingival crevicular fluid from inflammatory gingival tissue than from healthy sites. HMGB1 mRNA and protein are overexpressed in murine periodontal ligament fibroblasts stimulated with lipopolysaccharide (LPS) and IL-1β. Thus, this study sought to assess HMGB1 expression in peri-implant crevicular fluid (PICF) at each stage of peri-implant disease and to investigate the correlation between HMGB1 and peri-implant disease progress. The results demonstrated that the HMGB1 expression level in PICF is indicative of the progress of peri-implant disease and hence may be a useful diagnostic and prognostic biomarker for peri-implant tissue.
format	article
author	Jinpan Liu Ronghui Li Tongjun Liu Xiaohui Rausch-Fan Mingguo Wang
author_facet	Jinpan Liu Ronghui Li Tongjun Liu Xiaohui Rausch-Fan Mingguo Wang
author_sort	Jinpan Liu
title	High Mobility Group Box 1 Protein Level as a Novel Biomarker for the Development of Peri-Implant Disease
title_short	High Mobility Group Box 1 Protein Level as a Novel Biomarker for the Development of Peri-Implant Disease
title_full	High Mobility Group Box 1 Protein Level as a Novel Biomarker for the Development of Peri-Implant Disease
title_fullStr	High Mobility Group Box 1 Protein Level as a Novel Biomarker for the Development of Peri-Implant Disease
title_full_unstemmed	High Mobility Group Box 1 Protein Level as a Novel Biomarker for the Development of Peri-Implant Disease
title_sort	high mobility group box 1 protein level as a novel biomarker for the development of peri-implant disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/220edb951a344c0b9414564a6824448f
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High Mobility Group Box 1 Protein Level as a Novel Biomarker for the Development of Peri-Implant Disease

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