Prolonged depression-like behavior caused by immune challenge: influence of mouse strain and social environment.

Immune challenge by bacterial lipopolysaccharide (LPS) causes short-term behavioral changes indicative of depression. The present study sought to explore whether LPS is able to induce long-term changes in depression-related behavior and whether such an effect depends on mouse strain and social conte...

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Autores principales:	Evelin Painsipp, Martin J Köfer, Frank Sinner, Peter Holzer
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/22131f52d334450f839f7b5b8b398928
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spelling	oai:doaj.org-article:22131f52d334450f839f7b5b8b3989282021-11-18T06:52:35ZProlonged depression-like behavior caused by immune challenge: influence of mouse strain and social environment.1932-620310.1371/journal.pone.0020719https://doaj.org/article/22131f52d334450f839f7b5b8b3989282011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21673960/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Immune challenge by bacterial lipopolysaccharide (LPS) causes short-term behavioral changes indicative of depression. The present study sought to explore whether LPS is able to induce long-term changes in depression-related behavior and whether such an effect depends on mouse strain and social context. LPS (0.83 mg/kg) or vehicle was administered intraperitoneally to female CD1 and C57BL/6 mice that were housed singly or in groups of 4. Depression-like behavior was assessed with the forced swim test (FST) 1 and 28 days post-treatment. Group-housed CD1 mice exhibited depression-like behavior 1 day post-LPS, an effect that leveled off during the subsequent 28 days, while the behavior of singly housed CD1 mice was little affected. In contrast, singly housed C57BL/6 mice responded to LPS with an increase in depression-like behavior that was maintained for 4 weeks post-treatment and confirmed by the sucrose preference test. Group-housed C57BL/6 mice likewise displayed an increased depression-like behavior 4 weeks post-treatment. The behavioral changes induced by LPS in C57BL/6 mice were associated with a particularly pronounced rise of interleukin-6 in blood plasma within 1 day post-treatment and with changes in the dynamics of the corticosterone response to the FST. The current data demonstrate that immune challenge with LPS is able to induce prolonged depression-like behavior, an effect that depends on genetic background (strain). The discovery of an experimental model of long-term depression-like behavior after acute immune challenge is of relevance to the analysis of the epigenetic and pathophysiologic mechanisms of immune system-related affective disorders.Evelin PainsippMartin J KöferFrank SinnerPeter HolzerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 6, p e20719 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Evelin Painsipp Martin J Köfer Frank Sinner Peter Holzer Prolonged depression-like behavior caused by immune challenge: influence of mouse strain and social environment.
description	Immune challenge by bacterial lipopolysaccharide (LPS) causes short-term behavioral changes indicative of depression. The present study sought to explore whether LPS is able to induce long-term changes in depression-related behavior and whether such an effect depends on mouse strain and social context. LPS (0.83 mg/kg) or vehicle was administered intraperitoneally to female CD1 and C57BL/6 mice that were housed singly or in groups of 4. Depression-like behavior was assessed with the forced swim test (FST) 1 and 28 days post-treatment. Group-housed CD1 mice exhibited depression-like behavior 1 day post-LPS, an effect that leveled off during the subsequent 28 days, while the behavior of singly housed CD1 mice was little affected. In contrast, singly housed C57BL/6 mice responded to LPS with an increase in depression-like behavior that was maintained for 4 weeks post-treatment and confirmed by the sucrose preference test. Group-housed C57BL/6 mice likewise displayed an increased depression-like behavior 4 weeks post-treatment. The behavioral changes induced by LPS in C57BL/6 mice were associated with a particularly pronounced rise of interleukin-6 in blood plasma within 1 day post-treatment and with changes in the dynamics of the corticosterone response to the FST. The current data demonstrate that immune challenge with LPS is able to induce prolonged depression-like behavior, an effect that depends on genetic background (strain). The discovery of an experimental model of long-term depression-like behavior after acute immune challenge is of relevance to the analysis of the epigenetic and pathophysiologic mechanisms of immune system-related affective disorders.
format	article
author	Evelin Painsipp Martin J Köfer Frank Sinner Peter Holzer
author_facet	Evelin Painsipp Martin J Köfer Frank Sinner Peter Holzer
author_sort	Evelin Painsipp
title	Prolonged depression-like behavior caused by immune challenge: influence of mouse strain and social environment.
title_short	Prolonged depression-like behavior caused by immune challenge: influence of mouse strain and social environment.
title_full	Prolonged depression-like behavior caused by immune challenge: influence of mouse strain and social environment.
title_fullStr	Prolonged depression-like behavior caused by immune challenge: influence of mouse strain and social environment.
title_full_unstemmed	Prolonged depression-like behavior caused by immune challenge: influence of mouse strain and social environment.
title_sort	prolonged depression-like behavior caused by immune challenge: influence of mouse strain and social environment.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/22131f52d334450f839f7b5b8b398928
work_keys_str_mv	AT evelinpainsipp prolongeddepressionlikebehaviorcausedbyimmunechallengeinfluenceofmousestrainandsocialenvironment AT martinjkofer prolongeddepressionlikebehaviorcausedbyimmunechallengeinfluenceofmousestrainandsocialenvironment AT franksinner prolongeddepressionlikebehaviorcausedbyimmunechallengeinfluenceofmousestrainandsocialenvironment AT peterholzer prolongeddepressionlikebehaviorcausedbyimmunechallengeinfluenceofmousestrainandsocialenvironment
_version_	1718424277958524928

Prolonged depression-like behavior caused by immune challenge: influence of mouse strain and social environment.

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