Human Cytomegalovirus US28 Ligand Binding Activity Is Required for Latency in CD34<sup>+</sup> Hematopoietic Progenitor Cells and Humanized NSG Mice

Human Cytomegalovirus US28 Ligand Binding Activity Is Required for Latency in CD34<sup>+</sup> Hematopoietic Progenitor Cells and Humanized NSG Mice

ABSTRACT Human cytomegalovirus (HCMV) infection of CD34+ hematopoietic progenitor cells (CD34+ HPCs) provides a critical reservoir of virus in stem cell transplant patients, and viral reactivation remains a significant cause of morbidity and mortality. The HCMV chemokine receptor US28 is implicated...

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Autores principales: Lindsey B. Crawford, Patrizia Caposio, Craig Kreklywich, Andrew H. Pham, Meaghan H. Hancock, Taylor A. Jones, Patricia P. Smith, Andrew D. Yurochko, Jay A. Nelson, Daniel N. Streblow
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2019
Materias:
US28
hematopoiesis
human cytomegalovirus
latency
reactivation
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/2213cd7c92b0456f946b96b2a577e848
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