Mechanical loading of desmosomes depends on the magnitude and orientation of external stress

Desmosomes are intercellular adhesion complexes that connect the intermediate filament cytoskeletons of neighboring cells but direct evidence for their load-bearing nature is lacking. Here the authors develop FRET-based tension sensors to measure the forces experienced by desmoplakin and infer that...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Andrew J. Price, Anna-Lena Cost, Hanna Ungewiß, Jens Waschke, Alexander R. Dunn, Carsten Grashoff
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2215fbe56cc84a20a528fc6fe6ae67ab
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2215fbe56cc84a20a528fc6fe6ae67ab
record_format	dspace
spelling	oai:doaj.org-article:2215fbe56cc84a20a528fc6fe6ae67ab2021-12-02T14:39:25ZMechanical loading of desmosomes depends on the magnitude and orientation of external stress10.1038/s41467-018-07523-02041-1723https://doaj.org/article/2215fbe56cc84a20a528fc6fe6ae67ab2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07523-0https://doaj.org/toc/2041-1723Desmosomes are intercellular adhesion complexes that connect the intermediate filament cytoskeletons of neighboring cells but direct evidence for their load-bearing nature is lacking. Here the authors develop FRET-based tension sensors to measure the forces experienced by desmoplakin and infer that desmosomes become mechanically loaded when cells are exposed to external mechanical stresses.Andrew J. PriceAnna-Lena CostHanna UngewißJens WaschkeAlexander R. DunnCarsten GrashoffNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrew J. Price Anna-Lena Cost Hanna Ungewiß Jens Waschke Alexander R. Dunn Carsten Grashoff Mechanical loading of desmosomes depends on the magnitude and orientation of external stress
description	Desmosomes are intercellular adhesion complexes that connect the intermediate filament cytoskeletons of neighboring cells but direct evidence for their load-bearing nature is lacking. Here the authors develop FRET-based tension sensors to measure the forces experienced by desmoplakin and infer that desmosomes become mechanically loaded when cells are exposed to external mechanical stresses.
format	article
author	Andrew J. Price Anna-Lena Cost Hanna Ungewiß Jens Waschke Alexander R. Dunn Carsten Grashoff
author_facet	Andrew J. Price Anna-Lena Cost Hanna Ungewiß Jens Waschke Alexander R. Dunn Carsten Grashoff
author_sort	Andrew J. Price
title	Mechanical loading of desmosomes depends on the magnitude and orientation of external stress
title_short	Mechanical loading of desmosomes depends on the magnitude and orientation of external stress
title_full	Mechanical loading of desmosomes depends on the magnitude and orientation of external stress
title_fullStr	Mechanical loading of desmosomes depends on the magnitude and orientation of external stress
title_full_unstemmed	Mechanical loading of desmosomes depends on the magnitude and orientation of external stress
title_sort	mechanical loading of desmosomes depends on the magnitude and orientation of external stress
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2215fbe56cc84a20a528fc6fe6ae67ab
work_keys_str_mv	AT andrewjprice mechanicalloadingofdesmosomesdependsonthemagnitudeandorientationofexternalstress AT annalenacost mechanicalloadingofdesmosomesdependsonthemagnitudeandorientationofexternalstress AT hannaungewiß mechanicalloadingofdesmosomesdependsonthemagnitudeandorientationofexternalstress AT jenswaschke mechanicalloadingofdesmosomesdependsonthemagnitudeandorientationofexternalstress AT alexanderrdunn mechanicalloadingofdesmosomesdependsonthemagnitudeandorientationofexternalstress AT carstengrashoff mechanicalloadingofdesmosomesdependsonthemagnitudeandorientationofexternalstress
_version_	1718390580350812160

Mechanical loading of desmosomes depends on the magnitude and orientation of external stress

Ejemplares similares