Impact of Multifocality on the Recurrence of Papillary Thyroid Carcinoma

The incidence of thyroid cancer has dramatically increased over the last few decades, and up to 60% of patients have multifocal tumors. However, the prognostic impact of multifocality in patients with papillary thyroid carcinoma (PTC) remains unestablished and controversial. We evaluate whether mult...

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Autores principales:	Joohyun Woo, Hyeonkyeong Kim, Hyungju Kwon
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	papillary thyroid carcinoma multifocality recurrence Medicine R
Acceso en línea:	https://doaj.org/article/221c4fa02a69497baace5e2aec91b738
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spelling	oai:doaj.org-article:221c4fa02a69497baace5e2aec91b7382021-11-11T17:45:59ZImpact of Multifocality on the Recurrence of Papillary Thyroid Carcinoma10.3390/jcm102151442077-0383https://doaj.org/article/221c4fa02a69497baace5e2aec91b7382021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5144https://doaj.org/toc/2077-0383The incidence of thyroid cancer has dramatically increased over the last few decades, and up to 60% of patients have multifocal tumors. However, the prognostic impact of multifocality in patients with papillary thyroid carcinoma (PTC) remains unestablished and controversial. We evaluate whether multifocality can predict the recurrence of PTC. A total of 1249 patients who underwent total thyroidectomy for PTC at the Ewha Medical Center between March 2012 and December 2019 were reviewed. In this study, multifocality was found in 487 patients (39.0%) and the mean follow-up period was 5.5 ± 2.7 years. Multifocality was associated with high-risk features for recurrence, including extrathyroidal extension, lymph node metastasis, and margin involvement. After adjustment of those clinicopathological features, 10-year disease-free survival was 93.3% in patients with multifocal tumors, whereas those with unifocal disease showed 97.6% (<i>p</i> = 0.011). Multivariate Cox regression analysis indicated that male sex (HR 2.185, 95% CI 1.047–4.559), tumor size (HR 1.806, 95% CI 1.337–2.441), N1b LN metastasis (HR 3.603, 95% CI 1.207–10.757), and multifocality (HR 1.986, 95% CI 1.015–3.888) were independent predictors of recurrence. In conclusion, multifocality increased the risk of recurrence in patients with PTC. Patients with multifocal PTCs may need judicious treatment and follow-up approaches.Joohyun WooHyeonkyeong KimHyungju KwonMDPI AGarticlepapillary thyroid carcinomamultifocalityrecurrenceMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5144, p 5144 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	papillary thyroid carcinoma multifocality recurrence Medicine R
spellingShingle	papillary thyroid carcinoma multifocality recurrence Medicine R Joohyun Woo Hyeonkyeong Kim Hyungju Kwon Impact of Multifocality on the Recurrence of Papillary Thyroid Carcinoma
description	The incidence of thyroid cancer has dramatically increased over the last few decades, and up to 60% of patients have multifocal tumors. However, the prognostic impact of multifocality in patients with papillary thyroid carcinoma (PTC) remains unestablished and controversial. We evaluate whether multifocality can predict the recurrence of PTC. A total of 1249 patients who underwent total thyroidectomy for PTC at the Ewha Medical Center between March 2012 and December 2019 were reviewed. In this study, multifocality was found in 487 patients (39.0%) and the mean follow-up period was 5.5 ± 2.7 years. Multifocality was associated with high-risk features for recurrence, including extrathyroidal extension, lymph node metastasis, and margin involvement. After adjustment of those clinicopathological features, 10-year disease-free survival was 93.3% in patients with multifocal tumors, whereas those with unifocal disease showed 97.6% (<i>p</i> = 0.011). Multivariate Cox regression analysis indicated that male sex (HR 2.185, 95% CI 1.047–4.559), tumor size (HR 1.806, 95% CI 1.337–2.441), N1b LN metastasis (HR 3.603, 95% CI 1.207–10.757), and multifocality (HR 1.986, 95% CI 1.015–3.888) were independent predictors of recurrence. In conclusion, multifocality increased the risk of recurrence in patients with PTC. Patients with multifocal PTCs may need judicious treatment and follow-up approaches.
format	article
author	Joohyun Woo Hyeonkyeong Kim Hyungju Kwon
author_facet	Joohyun Woo Hyeonkyeong Kim Hyungju Kwon
author_sort	Joohyun Woo
title	Impact of Multifocality on the Recurrence of Papillary Thyroid Carcinoma
title_short	Impact of Multifocality on the Recurrence of Papillary Thyroid Carcinoma
title_full	Impact of Multifocality on the Recurrence of Papillary Thyroid Carcinoma
title_fullStr	Impact of Multifocality on the Recurrence of Papillary Thyroid Carcinoma
title_full_unstemmed	Impact of Multifocality on the Recurrence of Papillary Thyroid Carcinoma
title_sort	impact of multifocality on the recurrence of papillary thyroid carcinoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/221c4fa02a69497baace5e2aec91b738
work_keys_str_mv	AT joohyunwoo impactofmultifocalityontherecurrenceofpapillarythyroidcarcinoma AT hyeonkyeongkim impactofmultifocalityontherecurrenceofpapillarythyroidcarcinoma AT hyungjukwon impactofmultifocalityontherecurrenceofpapillarythyroidcarcinoma
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Impact of Multifocality on the Recurrence of Papillary Thyroid Carcinoma

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