A mouse model for a partially inactive obesity-associated human MC3R variant
The melanocortin receptor, MC3R, regulates organismal energy homeostasis. Here, Lee et al. create knock-in mice with the a mutated version of the human MC3R receptor found in obese children, and show these mice have more fat and smaller bone, yet are by and large metabolically healthy.
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Nature Portfolio
2016
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| Acceso en línea: | https://doaj.org/article/221cc26ea0964e6589ae36eae44b565c |
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oai:doaj.org-article:221cc26ea0964e6589ae36eae44b565c2021-12-02T15:34:11ZA mouse model for a partially inactive obesity-associated human MC3R variant10.1038/ncomms105222041-1723https://doaj.org/article/221cc26ea0964e6589ae36eae44b565c2016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10522https://doaj.org/toc/2041-1723The melanocortin receptor, MC3R, regulates organismal energy homeostasis. Here, Lee et al. create knock-in mice with the a mutated version of the human MC3R receptor found in obese children, and show these mice have more fat and smaller bone, yet are by and large metabolically healthy.Bonggi LeeJashin KooJoo Yun JunOksana GavrilovaYongjun LeeArnold Y. SeoDezmond C. Taylor-DouglasDiane C. Adler-WailesFaye ChenRyan GardnerDimitri KoutzoumisRoya Sherafat KazemzadehRobin B. RobersonJack A. YanovskiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Bonggi Lee Jashin Koo Joo Yun Jun Oksana Gavrilova Yongjun Lee Arnold Y. Seo Dezmond C. Taylor-Douglas Diane C. Adler-Wailes Faye Chen Ryan Gardner Dimitri Koutzoumis Roya Sherafat Kazemzadeh Robin B. Roberson Jack A. Yanovski A mouse model for a partially inactive obesity-associated human MC3R variant |
| description |
The melanocortin receptor, MC3R, regulates organismal energy homeostasis. Here, Lee et al. create knock-in mice with the a mutated version of the human MC3R receptor found in obese children, and show these mice have more fat and smaller bone, yet are by and large metabolically healthy. |
| format |
article |
| author |
Bonggi Lee Jashin Koo Joo Yun Jun Oksana Gavrilova Yongjun Lee Arnold Y. Seo Dezmond C. Taylor-Douglas Diane C. Adler-Wailes Faye Chen Ryan Gardner Dimitri Koutzoumis Roya Sherafat Kazemzadeh Robin B. Roberson Jack A. Yanovski |
| author_facet |
Bonggi Lee Jashin Koo Joo Yun Jun Oksana Gavrilova Yongjun Lee Arnold Y. Seo Dezmond C. Taylor-Douglas Diane C. Adler-Wailes Faye Chen Ryan Gardner Dimitri Koutzoumis Roya Sherafat Kazemzadeh Robin B. Roberson Jack A. Yanovski |
| author_sort |
Bonggi Lee |
| title |
A mouse model for a partially inactive obesity-associated human MC3R variant |
| title_short |
A mouse model for a partially inactive obesity-associated human MC3R variant |
| title_full |
A mouse model for a partially inactive obesity-associated human MC3R variant |
| title_fullStr |
A mouse model for a partially inactive obesity-associated human MC3R variant |
| title_full_unstemmed |
A mouse model for a partially inactive obesity-associated human MC3R variant |
| title_sort |
mouse model for a partially inactive obesity-associated human mc3r variant |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/221cc26ea0964e6589ae36eae44b565c |
| work_keys_str_mv |
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