A mouse model for a partially inactive obesity-associated human MC3R variant

A mouse model for a partially inactive obesity-associated human MC3R variant

The melanocortin receptor, MC3R, regulates organismal energy homeostasis. Here, Lee et al. create knock-in mice with the a mutated version of the human MC3R receptor found in obese children, and show these mice have more fat and smaller bone, yet are by and large metabolically healthy.

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Detalles Bibliográficos
Autores principales: Bonggi Lee, Jashin Koo, Joo Yun Jun, Oksana Gavrilova, Yongjun Lee, Arnold Y. Seo, Dezmond C. Taylor-Douglas, Diane C. Adler-Wailes, Faye Chen, Ryan Gardner, Dimitri Koutzoumis, Roya Sherafat Kazemzadeh, Robin B. Roberson, Jack A. Yanovski
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/221cc26ea0964e6589ae36eae44b565c
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