Chiral donor–acceptor azetines as powerful reactants for synthesis of amino acid derivatives

Chiral 3-azetidinones are structural analogues of medicinally relevant β-lactams, however their synthesis and reactivity are underexplored. Here, the authors show a highly enantioselective copper-catalyzed [3 + 1]-cycloaddition generating 2-azetidines, which react with nucleophiles yielding amino ac...

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Autores principales: Kostiantyn O. Marichev, Kuiyong Dong, Lynée A. Massey, Yongming Deng, Luca De Angelis, Kan Wang, Hadi Arman, Michael P. Doyle
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/2224efd87e00455cbf9a7b670366ac96
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