Successful salvage therapy of Fusarium endophthalmitis secondary to keratitis: an interventional case series

Grant M Comer, Maxwell S Stem, Stephen J SaxeUniversity of Michigan, Department of Ophthalmology and Visual Sciences, Ann Arbor, MI, USAPurpose: To describe a combination of treatment modalities used for the successful eradication of Fusarium endophthalmitis.Design: Interventional case series.Partic...

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Autores principales:	Comer GM, Stem MS, Saxe SJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/22254c59dc6643b2925da63367212ad3
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spelling	oai:doaj.org-article:22254c59dc6643b2925da63367212ad32021-12-02T00:51:36ZSuccessful salvage therapy of Fusarium endophthalmitis secondary to keratitis: an interventional case series1177-54671177-5483https://doaj.org/article/22254c59dc6643b2925da63367212ad32012-05-01T00:00:00Zhttp://www.dovepress.com/successful-salvage-therapy-of-fusarium-endophthalmitis-secondary-to-ke-a9870https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Grant M Comer, Maxwell S Stem, Stephen J SaxeUniversity of Michigan, Department of Ophthalmology and Visual Sciences, Ann Arbor, MI, USAPurpose: To describe a combination of treatment modalities used for the successful eradication of Fusarium endophthalmitis.Design: Interventional case series.Participants: Three consecutive patients with keratitis-associated Fusarium endophthalmitis.Methods: After failure of traditional management options, a combination of intravitreal and long-term, high-dose systemic voriconazole, topical antifungal medications, and surgical intervention, with penetrating keratoplasty, lensectomy, and endoscopic-guided pars plana vitrectomy, was administered to each patient.Results: All three cases achieved full resolution of the infection, with a final Snellen visual acuity score of 20/50 to 20/70.Conclusions: An aggressive combination of therapeutic modalities, including the removal of subiris abscesses, might be needed for the successful resolution of Fusarium endophthalmitis.Keywords: endophthalmitis, fungal, Fusarium, keratitis, keratoplasty, voriconazole&nbsp;Comer GMStem MSSaxe SJDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2012, Iss default, Pp 721-726 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Comer GM Stem MS Saxe SJ Successful salvage therapy of Fusarium endophthalmitis secondary to keratitis: an interventional case series
description	Grant M Comer, Maxwell S Stem, Stephen J SaxeUniversity of Michigan, Department of Ophthalmology and Visual Sciences, Ann Arbor, MI, USAPurpose: To describe a combination of treatment modalities used for the successful eradication of Fusarium endophthalmitis.Design: Interventional case series.Participants: Three consecutive patients with keratitis-associated Fusarium endophthalmitis.Methods: After failure of traditional management options, a combination of intravitreal and long-term, high-dose systemic voriconazole, topical antifungal medications, and surgical intervention, with penetrating keratoplasty, lensectomy, and endoscopic-guided pars plana vitrectomy, was administered to each patient.Results: All three cases achieved full resolution of the infection, with a final Snellen visual acuity score of 20/50 to 20/70.Conclusions: An aggressive combination of therapeutic modalities, including the removal of subiris abscesses, might be needed for the successful resolution of Fusarium endophthalmitis.Keywords: endophthalmitis, fungal, Fusarium, keratitis, keratoplasty, voriconazole&nbsp;
format	article
author	Comer GM Stem MS Saxe SJ
author_facet	Comer GM Stem MS Saxe SJ
author_sort	Comer GM
title	Successful salvage therapy of Fusarium endophthalmitis secondary to keratitis: an interventional case series
title_short	Successful salvage therapy of Fusarium endophthalmitis secondary to keratitis: an interventional case series
title_full	Successful salvage therapy of Fusarium endophthalmitis secondary to keratitis: an interventional case series
title_fullStr	Successful salvage therapy of Fusarium endophthalmitis secondary to keratitis: an interventional case series
title_full_unstemmed	Successful salvage therapy of Fusarium endophthalmitis secondary to keratitis: an interventional case series
title_sort	successful salvage therapy of fusarium endophthalmitis secondary to keratitis: an interventional case series
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/22254c59dc6643b2925da63367212ad3
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Successful salvage therapy of Fusarium endophthalmitis secondary to keratitis: an interventional case series

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