Global mapping of CARM1 substrates defines enzyme specificity and substrate recognition

Arginine methylation is an abundant post-translational modification catalysed by protein arginine methyltransferases (PRMTs). Here the authors use quantitative mass spectrometry to globally profile the substrates of the PRMT CARM1 in breast cancer cells, and establish a role for CARM1’s N-terminus i...

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Autores principales:	Evgenia Shishkova, Hao Zeng, Fabao Liu, Nicholas W. Kwiecien, Alexander S. Hebert, Joshua J. Coon, Wei Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/222565a41f79486c861ca88378e98eac
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spelling	oai:doaj.org-article:222565a41f79486c861ca88378e98eac2021-12-02T14:42:21ZGlobal mapping of CARM1 substrates defines enzyme specificity and substrate recognition10.1038/ncomms155712041-1723https://doaj.org/article/222565a41f79486c861ca88378e98eac2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15571https://doaj.org/toc/2041-1723Arginine methylation is an abundant post-translational modification catalysed by protein arginine methyltransferases (PRMTs). Here the authors use quantitative mass spectrometry to globally profile the substrates of the PRMT CARM1 in breast cancer cells, and establish a role for CARM1’s N-terminus in substrate recognition.Evgenia ShishkovaHao ZengFabao LiuNicholas W. KwiecienAlexander S. HebertJoshua J. CoonWei XuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Evgenia Shishkova Hao Zeng Fabao Liu Nicholas W. Kwiecien Alexander S. Hebert Joshua J. Coon Wei Xu Global mapping of CARM1 substrates defines enzyme specificity and substrate recognition
description	Arginine methylation is an abundant post-translational modification catalysed by protein arginine methyltransferases (PRMTs). Here the authors use quantitative mass spectrometry to globally profile the substrates of the PRMT CARM1 in breast cancer cells, and establish a role for CARM1’s N-terminus in substrate recognition.
format	article
author	Evgenia Shishkova Hao Zeng Fabao Liu Nicholas W. Kwiecien Alexander S. Hebert Joshua J. Coon Wei Xu
author_facet	Evgenia Shishkova Hao Zeng Fabao Liu Nicholas W. Kwiecien Alexander S. Hebert Joshua J. Coon Wei Xu
author_sort	Evgenia Shishkova
title	Global mapping of CARM1 substrates defines enzyme specificity and substrate recognition
title_short	Global mapping of CARM1 substrates defines enzyme specificity and substrate recognition
title_full	Global mapping of CARM1 substrates defines enzyme specificity and substrate recognition
title_fullStr	Global mapping of CARM1 substrates defines enzyme specificity and substrate recognition
title_full_unstemmed	Global mapping of CARM1 substrates defines enzyme specificity and substrate recognition
title_sort	global mapping of carm1 substrates defines enzyme specificity and substrate recognition
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/222565a41f79486c861ca88378e98eac
work_keys_str_mv	AT evgeniashishkova globalmappingofcarm1substratesdefinesenzymespecificityandsubstraterecognition AT haozeng globalmappingofcarm1substratesdefinesenzymespecificityandsubstraterecognition AT fabaoliu globalmappingofcarm1substratesdefinesenzymespecificityandsubstraterecognition AT nicholaswkwiecien globalmappingofcarm1substratesdefinesenzymespecificityandsubstraterecognition AT alexandershebert globalmappingofcarm1substratesdefinesenzymespecificityandsubstraterecognition AT joshuajcoon globalmappingofcarm1substratesdefinesenzymespecificityandsubstraterecognition AT weixu globalmappingofcarm1substratesdefinesenzymespecificityandsubstraterecognition
_version_	1718389677744979968

Global mapping of CARM1 substrates defines enzyme specificity and substrate recognition

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