Same Brain, Different Look?—The Impact of Scanner, Sequence and Preprocessing on Diffusion Imaging Outcome Parameters

In clinical diagnostics and longitudinal studies, the reproducibility of MRI assessments is of high importance in order to detect pathological changes, but developments in MRI hard- and software often outrun extended periods of data acquisition and analysis. This could potentially introduce artefact...

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Autores principales:	Ronja Thieleking, Rui Zhang, Maria Paerisch, Kerstin Wirkner, Alfred Anwander, Frauke Beyer, Arno Villringer, A. Veronica Witte
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	diffusion magnetic resonance imaging white matter fractional anisotropy multi-centre reproducibility imaging artefacts Medicine R
Acceso en línea:	https://doaj.org/article/2227311d166149248c11d413d69d0a56
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spelling	oai:doaj.org-article:2227311d166149248c11d413d69d0a562021-11-11T17:37:05ZSame Brain, Different Look?—The Impact of Scanner, Sequence and Preprocessing on Diffusion Imaging Outcome Parameters10.3390/jcm102149872077-0383https://doaj.org/article/2227311d166149248c11d413d69d0a562021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4987https://doaj.org/toc/2077-0383In clinical diagnostics and longitudinal studies, the reproducibility of MRI assessments is of high importance in order to detect pathological changes, but developments in MRI hard- and software often outrun extended periods of data acquisition and analysis. This could potentially introduce artefactual changes or mask pathological alterations. However, if and how changes of MRI hardware, scanning protocols or preprocessing software affect complex neuroimaging outcomes from, e.g., diffusion weighted imaging (DWI) remains largely understudied. We therefore compared DWI outcomes and artefact severity of 121 healthy participants (age range 19–54 years) who underwent two matched DWI protocols (Siemens product and Center for Magnetic Resonance Research sequence) at two sites (Siemens 3T Magnetom Verio and Skyra<sup>fit</sup>). After different preprocessing steps, fractional anisotropy (FA) and mean diffusivity (MD) maps, obtained by tensor fitting, were processed with tract-based spatial statistics (TBSS). Inter-scanner and inter-sequence variability of skeletonised FA values reached up to 5% and differed largely in magnitude and direction across the brain. Skeletonised MD values differed up to 14% between scanners. We here demonstrate that DTI outcome measures strongly depend on imaging site and software, and that these biases vary between brain regions. These regionally inhomogeneous biases may exceed and considerably confound physiological effects such as ageing, highlighting the need to harmonise data acquisition and analysis. Future studies thus need to implement novel strategies to augment neuroimaging data reliability and replicability.Ronja ThielekingRui ZhangMaria PaerischKerstin WirknerAlfred AnwanderFrauke BeyerArno VillringerA. Veronica WitteMDPI AGarticlediffusion magnetic resonance imagingwhite matterfractional anisotropymulti-centrereproducibilityimaging artefactsMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4987, p 4987 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diffusion magnetic resonance imaging white matter fractional anisotropy multi-centre reproducibility imaging artefacts Medicine R
spellingShingle	diffusion magnetic resonance imaging white matter fractional anisotropy multi-centre reproducibility imaging artefacts Medicine R Ronja Thieleking Rui Zhang Maria Paerisch Kerstin Wirkner Alfred Anwander Frauke Beyer Arno Villringer A. Veronica Witte Same Brain, Different Look?—The Impact of Scanner, Sequence and Preprocessing on Diffusion Imaging Outcome Parameters
description	In clinical diagnostics and longitudinal studies, the reproducibility of MRI assessments is of high importance in order to detect pathological changes, but developments in MRI hard- and software often outrun extended periods of data acquisition and analysis. This could potentially introduce artefactual changes or mask pathological alterations. However, if and how changes of MRI hardware, scanning protocols or preprocessing software affect complex neuroimaging outcomes from, e.g., diffusion weighted imaging (DWI) remains largely understudied. We therefore compared DWI outcomes and artefact severity of 121 healthy participants (age range 19–54 years) who underwent two matched DWI protocols (Siemens product and Center for Magnetic Resonance Research sequence) at two sites (Siemens 3T Magnetom Verio and Skyra<sup>fit</sup>). After different preprocessing steps, fractional anisotropy (FA) and mean diffusivity (MD) maps, obtained by tensor fitting, were processed with tract-based spatial statistics (TBSS). Inter-scanner and inter-sequence variability of skeletonised FA values reached up to 5% and differed largely in magnitude and direction across the brain. Skeletonised MD values differed up to 14% between scanners. We here demonstrate that DTI outcome measures strongly depend on imaging site and software, and that these biases vary between brain regions. These regionally inhomogeneous biases may exceed and considerably confound physiological effects such as ageing, highlighting the need to harmonise data acquisition and analysis. Future studies thus need to implement novel strategies to augment neuroimaging data reliability and replicability.
format	article
author	Ronja Thieleking Rui Zhang Maria Paerisch Kerstin Wirkner Alfred Anwander Frauke Beyer Arno Villringer A. Veronica Witte
author_facet	Ronja Thieleking Rui Zhang Maria Paerisch Kerstin Wirkner Alfred Anwander Frauke Beyer Arno Villringer A. Veronica Witte
author_sort	Ronja Thieleking
title	Same Brain, Different Look?—The Impact of Scanner, Sequence and Preprocessing on Diffusion Imaging Outcome Parameters
title_short	Same Brain, Different Look?—The Impact of Scanner, Sequence and Preprocessing on Diffusion Imaging Outcome Parameters
title_full	Same Brain, Different Look?—The Impact of Scanner, Sequence and Preprocessing on Diffusion Imaging Outcome Parameters
title_fullStr	Same Brain, Different Look?—The Impact of Scanner, Sequence and Preprocessing on Diffusion Imaging Outcome Parameters
title_full_unstemmed	Same Brain, Different Look?—The Impact of Scanner, Sequence and Preprocessing on Diffusion Imaging Outcome Parameters
title_sort	same brain, different look?—the impact of scanner, sequence and preprocessing on diffusion imaging outcome parameters
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2227311d166149248c11d413d69d0a56
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Same Brain, Different Look?—The Impact of Scanner, Sequence and Preprocessing on Diffusion Imaging Outcome Parameters

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