Profiling of tumour-associated microbiota in human hepatocellular carcinoma

Abstract Liver cancer is the fourth leading cause of cancer-related death. Hepatocellular carcinoma (HCC) is a primary liver cancer that results from chronic hepatitis caused by multiple predisposing factors such as viral infection, alcohol consumption, and non-alcoholic fatty liver disease. Accumul...

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Autores principales:	Seiga Komiyama, Takahiro Yamada, Nobuyuki Takemura, Norihiro Kokudo, Koji Hase, Yuki I. Kawamura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2228e235924542448d0773e953da3928
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spelling	oai:doaj.org-article:2228e235924542448d0773e953da39282021-12-02T15:45:27ZProfiling of tumour-associated microbiota in human hepatocellular carcinoma10.1038/s41598-021-89963-12045-2322https://doaj.org/article/2228e235924542448d0773e953da39282021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89963-1https://doaj.org/toc/2045-2322Abstract Liver cancer is the fourth leading cause of cancer-related death. Hepatocellular carcinoma (HCC) is a primary liver cancer that results from chronic hepatitis caused by multiple predisposing factors such as viral infection, alcohol consumption, and non-alcoholic fatty liver disease. Accumulating studies have indicated that dysfunction of the gut epithelial barrier and hepatic translocation of gut microbes may be implicated in the pathogenesis of HCC. However, the translocated bacteria in HCC patients remains unclear. Here, we characterised tumour-associated microbiota in patients with liver cancer and focused on HCC. We observed that the number of amplicon sequence variants in tumour-associated microbiota was significantly higher compared with that in non-tumour regions of the liver. The tumour-associated microbiota consisted of Bacteroidetes, Firmicutes, and Proteobacteria as the dominant phyla. We identified an unclassified genus that belonged to the Bacteroides, Romboutsia, uncultured bacterium of Lachnospiraceae as a signature taxon for primary liver cancer. Additionally, we identified Ruminococcus gnavus as a signature taxon for HCC patients infected with hepatitis B and/or hepatitis C viruses. This study suggests that tumour microbiota may contribute to the pathology of HCC.Seiga KomiyamaTakahiro YamadaNobuyuki TakemuraNorihiro KokudoKoji HaseYuki I. KawamuraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seiga Komiyama Takahiro Yamada Nobuyuki Takemura Norihiro Kokudo Koji Hase Yuki I. Kawamura Profiling of tumour-associated microbiota in human hepatocellular carcinoma
description	Abstract Liver cancer is the fourth leading cause of cancer-related death. Hepatocellular carcinoma (HCC) is a primary liver cancer that results from chronic hepatitis caused by multiple predisposing factors such as viral infection, alcohol consumption, and non-alcoholic fatty liver disease. Accumulating studies have indicated that dysfunction of the gut epithelial barrier and hepatic translocation of gut microbes may be implicated in the pathogenesis of HCC. However, the translocated bacteria in HCC patients remains unclear. Here, we characterised tumour-associated microbiota in patients with liver cancer and focused on HCC. We observed that the number of amplicon sequence variants in tumour-associated microbiota was significantly higher compared with that in non-tumour regions of the liver. The tumour-associated microbiota consisted of Bacteroidetes, Firmicutes, and Proteobacteria as the dominant phyla. We identified an unclassified genus that belonged to the Bacteroides, Romboutsia, uncultured bacterium of Lachnospiraceae as a signature taxon for primary liver cancer. Additionally, we identified Ruminococcus gnavus as a signature taxon for HCC patients infected with hepatitis B and/or hepatitis C viruses. This study suggests that tumour microbiota may contribute to the pathology of HCC.
format	article
author	Seiga Komiyama Takahiro Yamada Nobuyuki Takemura Norihiro Kokudo Koji Hase Yuki I. Kawamura
author_facet	Seiga Komiyama Takahiro Yamada Nobuyuki Takemura Norihiro Kokudo Koji Hase Yuki I. Kawamura
author_sort	Seiga Komiyama
title	Profiling of tumour-associated microbiota in human hepatocellular carcinoma
title_short	Profiling of tumour-associated microbiota in human hepatocellular carcinoma
title_full	Profiling of tumour-associated microbiota in human hepatocellular carcinoma
title_fullStr	Profiling of tumour-associated microbiota in human hepatocellular carcinoma
title_full_unstemmed	Profiling of tumour-associated microbiota in human hepatocellular carcinoma
title_sort	profiling of tumour-associated microbiota in human hepatocellular carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2228e235924542448d0773e953da3928
work_keys_str_mv	AT seigakomiyama profilingoftumourassociatedmicrobiotainhumanhepatocellularcarcinoma AT takahiroyamada profilingoftumourassociatedmicrobiotainhumanhepatocellularcarcinoma AT nobuyukitakemura profilingoftumourassociatedmicrobiotainhumanhepatocellularcarcinoma AT norihirokokudo profilingoftumourassociatedmicrobiotainhumanhepatocellularcarcinoma AT kojihase profilingoftumourassociatedmicrobiotainhumanhepatocellularcarcinoma AT yukiikawamura profilingoftumourassociatedmicrobiotainhumanhepatocellularcarcinoma
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Profiling of tumour-associated microbiota in human hepatocellular carcinoma

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