Comparative effectiveness of erythropoietin alpha and beta in hemodialysis patients: a single-center prospective observational study

Background and objectives Anemia is a prevalent complication endured by patients with chronic renal disease. Renal anemia also leads to the development of cardio-vascular complications. Epoetin alpha and beta are recombinant human erythropoietin prioritized for managing anemia in hemodialysis patien...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Muhammad Nadeem Ahsan, Naila Asif, Shafqat Waqar Khanzada, Muhammad Sohaib Asghar, Farah Yasmin, Faran Khalid, Shameen Fareed, Syeda Ghazala Irshad
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	ckd esrd anemia erythropoietin hemoglobin dialysis Internal medicine RC31-1245
Acceso en línea:	https://doaj.org/article/222aa012430e4f40a48a15648efcaffa
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:222aa012430e4f40a48a15648efcaffa
record_format	dspace
spelling	oai:doaj.org-article:222aa012430e4f40a48a15648efcaffa2021-11-17T14:21:57ZComparative effectiveness of erythropoietin alpha and beta in hemodialysis patients: a single-center prospective observational study2000-966610.1080/20009666.2021.1983980https://doaj.org/article/222aa012430e4f40a48a15648efcaffa2021-11-01T00:00:00Zhttp://dx.doi.org/10.1080/20009666.2021.1983980https://doaj.org/toc/2000-9666Background and objectives Anemia is a prevalent complication endured by patients with chronic renal disease. Renal anemia also leads to the development of cardio-vascular complications. Epoetin alpha and beta are recombinant human erythropoietin prioritized for managing anemia in hemodialysis patients. The current study aimed to compare the therapeutic efficacy of both erythropoietin alpha and erythropoietin beta in treating renal anemia. Materials and methods This prospective observational study was conducted in a Renal Dialysis Centre at a tertiary care Hospital of Karachi, Pakistan for a period of 3 months. The two erythropoietin products used were human recombinant erythropoietin alpha (Tropin®) and erythropoietin beta (Recormon®). Both groups were age-matched, BMI, eGFR, gender, and comorbidities like diabetes and hypertension were indifferent. The comparative analysis was performed after the completion of 3 months. Results A total of 94 participants were included in the analysis, 54 in group A and 40 in group B. Mean albumin, urea, creatinine, ferritin, iron, and transferrin saturation at inclusion were statistically insignificant, TIBC was higher in group A (p = 0.005) and CRP levels were slightly higher in group B (p = 0.050). There was significant improvement in Hb level (p = 0.025), PCV (p = 0.001), and RBC count (p = 0.007) in group B. While in group A, there was significantly increased MCV (p = 0.005) and MCHC (p = 0.002). In intention to treat analysis, 22.2% of subjects in group A and 40.0% in group B reached desired Hb levels of ≥11 g/l after 3 months. Conclusion In our assessment of hemodialysis patients, erythropoietin beta was found more effective than erythropoietin alpha.Muhammad Nadeem AhsanNaila AsifShafqat Waqar KhanzadaMuhammad Sohaib AsgharFarah YasminFaran KhalidShameen FareedSyeda Ghazala IrshadTaylor & Francis GrouparticleckdesrdanemiaerythropoietinhemoglobindialysisInternal medicineRC31-1245ENJournal of Community Hospital Internal Medicine Perspectives, Vol 11, Iss 6, Pp 782-786 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ckd esrd anemia erythropoietin hemoglobin dialysis Internal medicine RC31-1245
spellingShingle	ckd esrd anemia erythropoietin hemoglobin dialysis Internal medicine RC31-1245 Muhammad Nadeem Ahsan Naila Asif Shafqat Waqar Khanzada Muhammad Sohaib Asghar Farah Yasmin Faran Khalid Shameen Fareed Syeda Ghazala Irshad Comparative effectiveness of erythropoietin alpha and beta in hemodialysis patients: a single-center prospective observational study
description	Background and objectives Anemia is a prevalent complication endured by patients with chronic renal disease. Renal anemia also leads to the development of cardio-vascular complications. Epoetin alpha and beta are recombinant human erythropoietin prioritized for managing anemia in hemodialysis patients. The current study aimed to compare the therapeutic efficacy of both erythropoietin alpha and erythropoietin beta in treating renal anemia. Materials and methods This prospective observational study was conducted in a Renal Dialysis Centre at a tertiary care Hospital of Karachi, Pakistan for a period of 3 months. The two erythropoietin products used were human recombinant erythropoietin alpha (Tropin®) and erythropoietin beta (Recormon®). Both groups were age-matched, BMI, eGFR, gender, and comorbidities like diabetes and hypertension were indifferent. The comparative analysis was performed after the completion of 3 months. Results A total of 94 participants were included in the analysis, 54 in group A and 40 in group B. Mean albumin, urea, creatinine, ferritin, iron, and transferrin saturation at inclusion were statistically insignificant, TIBC was higher in group A (p = 0.005) and CRP levels were slightly higher in group B (p = 0.050). There was significant improvement in Hb level (p = 0.025), PCV (p = 0.001), and RBC count (p = 0.007) in group B. While in group A, there was significantly increased MCV (p = 0.005) and MCHC (p = 0.002). In intention to treat analysis, 22.2% of subjects in group A and 40.0% in group B reached desired Hb levels of ≥11 g/l after 3 months. Conclusion In our assessment of hemodialysis patients, erythropoietin beta was found more effective than erythropoietin alpha.
format	article
author	Muhammad Nadeem Ahsan Naila Asif Shafqat Waqar Khanzada Muhammad Sohaib Asghar Farah Yasmin Faran Khalid Shameen Fareed Syeda Ghazala Irshad
author_facet	Muhammad Nadeem Ahsan Naila Asif Shafqat Waqar Khanzada Muhammad Sohaib Asghar Farah Yasmin Faran Khalid Shameen Fareed Syeda Ghazala Irshad
author_sort	Muhammad Nadeem Ahsan
title	Comparative effectiveness of erythropoietin alpha and beta in hemodialysis patients: a single-center prospective observational study
title_short	Comparative effectiveness of erythropoietin alpha and beta in hemodialysis patients: a single-center prospective observational study
title_full	Comparative effectiveness of erythropoietin alpha and beta in hemodialysis patients: a single-center prospective observational study
title_fullStr	Comparative effectiveness of erythropoietin alpha and beta in hemodialysis patients: a single-center prospective observational study
title_full_unstemmed	Comparative effectiveness of erythropoietin alpha and beta in hemodialysis patients: a single-center prospective observational study
title_sort	comparative effectiveness of erythropoietin alpha and beta in hemodialysis patients: a single-center prospective observational study
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/222aa012430e4f40a48a15648efcaffa
work_keys_str_mv	AT muhammadnadeemahsan comparativeeffectivenessoferythropoietinalphaandbetainhemodialysispatientsasinglecenterprospectiveobservationalstudy AT nailaasif comparativeeffectivenessoferythropoietinalphaandbetainhemodialysispatientsasinglecenterprospectiveobservationalstudy AT shafqatwaqarkhanzada comparativeeffectivenessoferythropoietinalphaandbetainhemodialysispatientsasinglecenterprospectiveobservationalstudy AT muhammadsohaibasghar comparativeeffectivenessoferythropoietinalphaandbetainhemodialysispatientsasinglecenterprospectiveobservationalstudy AT farahyasmin comparativeeffectivenessoferythropoietinalphaandbetainhemodialysispatientsasinglecenterprospectiveobservationalstudy AT farankhalid comparativeeffectivenessoferythropoietinalphaandbetainhemodialysispatientsasinglecenterprospectiveobservationalstudy AT shameenfareed comparativeeffectivenessoferythropoietinalphaandbetainhemodialysispatientsasinglecenterprospectiveobservationalstudy AT syedaghazalairshad comparativeeffectivenessoferythropoietinalphaandbetainhemodialysispatientsasinglecenterprospectiveobservationalstudy
_version_	1718425468856696832

Comparative effectiveness of erythropoietin alpha and beta in hemodialysis patients: a single-center prospective observational study

Ejemplares similares