Neurophysiological markers of ADHD symptoms in typically-developing children

Abstract Children with attention-deficit/hyperactivity disorder (ADHD) are characterized by symptoms of inattention, impulsivity, and hyperactivity. Neurophysiological correlates of ADHD include changes in the P3 component of event-related brain potentials (ERPs). Motivated by recent advances toward...

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Autores principales:	Kirsten Hilger, Jona Sassenhagen, Jan Kühnhausen, Merle Reuter, Ulrike Schwarz, Caterina Gawrilow, Christian J. Fiebach
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/222c34d565b24e8a93c90374812895f7
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spelling	oai:doaj.org-article:222c34d565b24e8a93c90374812895f72021-12-02T14:01:28ZNeurophysiological markers of ADHD symptoms in typically-developing children10.1038/s41598-020-80562-02045-2322https://doaj.org/article/222c34d565b24e8a93c90374812895f72020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80562-0https://doaj.org/toc/2045-2322Abstract Children with attention-deficit/hyperactivity disorder (ADHD) are characterized by symptoms of inattention, impulsivity, and hyperactivity. Neurophysiological correlates of ADHD include changes in the P3 component of event-related brain potentials (ERPs). Motivated by recent advances towards a more dimensional understanding of ADHD, we investigate whether ADHD-related ERP markers relate to continuous variations in attention and executive functioning also in typically-developing children. ERPs were measured while 31 school children (9–11 years) completed an adapted version of the Continuous Performance Task that additionally to inhibitory processes also isolates effects of physical stimulus salience. Children with higher levels of parent-reported ADHD symptoms did not differ in task performance, but exhibited smaller P3 amplitudes related to stimulus salience. Furthermore, ADHD symptoms were associated with the variability of neural responses over time: Children with higher levels of ADHD symptoms demonstrated lower variability in inhibition- and salience-related P3 amplitudes. No effects were observed for ERP latencies and the salience-related N2. By demonstrating that ADHD-associated neurophysiological mechanisms of inhibition and salience processing covary with attention and executive functioning in a children community sample, our study provides neurophysiological support for dimensional models of ADHD. Also, temporal variability in event-related potentials is highlighted as additional indicator of ADHD requiring further investigation.Kirsten HilgerJona SassenhagenJan KühnhausenMerle ReuterUlrike SchwarzCaterina GawrilowChristian J. FiebachNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kirsten Hilger Jona Sassenhagen Jan Kühnhausen Merle Reuter Ulrike Schwarz Caterina Gawrilow Christian J. Fiebach Neurophysiological markers of ADHD symptoms in typically-developing children
description	Abstract Children with attention-deficit/hyperactivity disorder (ADHD) are characterized by symptoms of inattention, impulsivity, and hyperactivity. Neurophysiological correlates of ADHD include changes in the P3 component of event-related brain potentials (ERPs). Motivated by recent advances towards a more dimensional understanding of ADHD, we investigate whether ADHD-related ERP markers relate to continuous variations in attention and executive functioning also in typically-developing children. ERPs were measured while 31 school children (9–11 years) completed an adapted version of the Continuous Performance Task that additionally to inhibitory processes also isolates effects of physical stimulus salience. Children with higher levels of parent-reported ADHD symptoms did not differ in task performance, but exhibited smaller P3 amplitudes related to stimulus salience. Furthermore, ADHD symptoms were associated with the variability of neural responses over time: Children with higher levels of ADHD symptoms demonstrated lower variability in inhibition- and salience-related P3 amplitudes. No effects were observed for ERP latencies and the salience-related N2. By demonstrating that ADHD-associated neurophysiological mechanisms of inhibition and salience processing covary with attention and executive functioning in a children community sample, our study provides neurophysiological support for dimensional models of ADHD. Also, temporal variability in event-related potentials is highlighted as additional indicator of ADHD requiring further investigation.
format	article
author	Kirsten Hilger Jona Sassenhagen Jan Kühnhausen Merle Reuter Ulrike Schwarz Caterina Gawrilow Christian J. Fiebach
author_facet	Kirsten Hilger Jona Sassenhagen Jan Kühnhausen Merle Reuter Ulrike Schwarz Caterina Gawrilow Christian J. Fiebach
author_sort	Kirsten Hilger
title	Neurophysiological markers of ADHD symptoms in typically-developing children
title_short	Neurophysiological markers of ADHD symptoms in typically-developing children
title_full	Neurophysiological markers of ADHD symptoms in typically-developing children
title_fullStr	Neurophysiological markers of ADHD symptoms in typically-developing children
title_full_unstemmed	Neurophysiological markers of ADHD symptoms in typically-developing children
title_sort	neurophysiological markers of adhd symptoms in typically-developing children
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/222c34d565b24e8a93c90374812895f7
work_keys_str_mv	AT kirstenhilger neurophysiologicalmarkersofadhdsymptomsintypicallydevelopingchildren AT jonasassenhagen neurophysiologicalmarkersofadhdsymptomsintypicallydevelopingchildren AT jankuhnhausen neurophysiologicalmarkersofadhdsymptomsintypicallydevelopingchildren AT merlereuter neurophysiologicalmarkersofadhdsymptomsintypicallydevelopingchildren AT ulrikeschwarz neurophysiologicalmarkersofadhdsymptomsintypicallydevelopingchildren AT caterinagawrilow neurophysiologicalmarkersofadhdsymptomsintypicallydevelopingchildren AT christianjfiebach neurophysiologicalmarkersofadhdsymptomsintypicallydevelopingchildren
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Neurophysiological markers of ADHD symptoms in typically-developing children

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