An in vivo confocal microscopy study of corneal changes in patients with systemic sclerosis

Abstract To investigate corneal microstructure of systemic sclerosis (SSc) patients using in vivo confocal microscopy (IVCM). 33 patients with SSc and 30 age-matched healthy subjects were recruited. All participants underwent comprehensive ophthalmic examination including IVCM (Heidelberg Retina Tom...

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Autores principales:	Eszter Szalai, Gabriella Szucs, Szilvia Szamosi, Zsuzsa Aszalos, Ildiko Afra, Adam Kemeny-Beke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/222dd37c6ba4438a9268730a36cc44c4
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spelling	oai:doaj.org-article:222dd37c6ba4438a9268730a36cc44c42021-12-02T16:53:11ZAn in vivo confocal microscopy study of corneal changes in patients with systemic sclerosis10.1038/s41598-021-90594-92045-2322https://doaj.org/article/222dd37c6ba4438a9268730a36cc44c42021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90594-9https://doaj.org/toc/2045-2322Abstract To investigate corneal microstructure of systemic sclerosis (SSc) patients using in vivo confocal microscopy (IVCM). 33 patients with SSc and 30 age-matched healthy subjects were recruited. All participants underwent comprehensive ophthalmic examination including IVCM (Heidelberg Retina Tomograph III, Heidelberg Engineering GmbH, Heidelberg, Germany) and ocular surface evaluation. Subbasal nerve plexus morphology was investigated using automated software analysis (ACCMetrics V3; University of Manchester, Manchester, UK). Keratocyte cell densities in the anterior stroma were significantly lower in patients with SSc compared to controls (P < 0.0001). In 7 SSc patients no keratocyte nuclei were identified in the anterior stroma and in most patients scattered hyperreflective punctate material were observed in the anterior stroma. Significantly lower subbasal nerve fiber parameters were found in patients with SSc compared to healthy subjects (P < 0.05). There were no significant correlations between the duration of SSc and any of the corneal cell density values. Tear break-up time values (4.82 ± 3.15 s) and Ocular Surface Disease Index scores (33.27 ± 30.11) were abnormal, Schirmer values (6.78 ± 5.82 mm) were borderline in SSc patients. In SSc, corneal morphological changes and accumulation of punctate material in the stroma was detected with confocal microscopy. Severe ocular surface disease was observed in SSc patients with significant impairment in subbasal nerve plexus morphology resembling peripheral neuropathy.Eszter SzalaiGabriella SzucsSzilvia SzamosiZsuzsa AszalosIldiko AfraAdam Kemeny-BekeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eszter Szalai Gabriella Szucs Szilvia Szamosi Zsuzsa Aszalos Ildiko Afra Adam Kemeny-Beke An in vivo confocal microscopy study of corneal changes in patients with systemic sclerosis
description	Abstract To investigate corneal microstructure of systemic sclerosis (SSc) patients using in vivo confocal microscopy (IVCM). 33 patients with SSc and 30 age-matched healthy subjects were recruited. All participants underwent comprehensive ophthalmic examination including IVCM (Heidelberg Retina Tomograph III, Heidelberg Engineering GmbH, Heidelberg, Germany) and ocular surface evaluation. Subbasal nerve plexus morphology was investigated using automated software analysis (ACCMetrics V3; University of Manchester, Manchester, UK). Keratocyte cell densities in the anterior stroma were significantly lower in patients with SSc compared to controls (P < 0.0001). In 7 SSc patients no keratocyte nuclei were identified in the anterior stroma and in most patients scattered hyperreflective punctate material were observed in the anterior stroma. Significantly lower subbasal nerve fiber parameters were found in patients with SSc compared to healthy subjects (P < 0.05). There were no significant correlations between the duration of SSc and any of the corneal cell density values. Tear break-up time values (4.82 ± 3.15 s) and Ocular Surface Disease Index scores (33.27 ± 30.11) were abnormal, Schirmer values (6.78 ± 5.82 mm) were borderline in SSc patients. In SSc, corneal morphological changes and accumulation of punctate material in the stroma was detected with confocal microscopy. Severe ocular surface disease was observed in SSc patients with significant impairment in subbasal nerve plexus morphology resembling peripheral neuropathy.
format	article
author	Eszter Szalai Gabriella Szucs Szilvia Szamosi Zsuzsa Aszalos Ildiko Afra Adam Kemeny-Beke
author_facet	Eszter Szalai Gabriella Szucs Szilvia Szamosi Zsuzsa Aszalos Ildiko Afra Adam Kemeny-Beke
author_sort	Eszter Szalai
title	An in vivo confocal microscopy study of corneal changes in patients with systemic sclerosis
title_short	An in vivo confocal microscopy study of corneal changes in patients with systemic sclerosis
title_full	An in vivo confocal microscopy study of corneal changes in patients with systemic sclerosis
title_fullStr	An in vivo confocal microscopy study of corneal changes in patients with systemic sclerosis
title_full_unstemmed	An in vivo confocal microscopy study of corneal changes in patients with systemic sclerosis
title_sort	in vivo confocal microscopy study of corneal changes in patients with systemic sclerosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/222dd37c6ba4438a9268730a36cc44c4
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An in vivo confocal microscopy study of corneal changes in patients with systemic sclerosis

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