Analysis of Funding Source and Spin in the Reporting of Studies of Intravitreal Corticosteroid Therapy for Diabetic Macular Edema: A Systematic Review

Harrish Nithianandan,1 Ajay E Kuriyan,2 Michael J Venincasa,3 Jayanth Sridhar3 1Department of Ophthalmology & Visual Sciences, McGill University, Montreal, Quebec, Canada; 2Retina Service, Wills Eye Hospital, Philadelphia, PA, USA; 3Department of Ophthalmology, Bascom Palmer Eye Institute, M...

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Autores principales:	Nithianandan H, Kuriyan AE, Venincasa MJ, Sridhar J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	corticosteroids diabetic retinopathy intravitreal therapy macular edema systematic review Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/222e39e4f468403588d1cb5193c44253
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spelling	oai:doaj.org-article:222e39e4f468403588d1cb5193c442532021-12-02T11:09:48ZAnalysis of Funding Source and Spin in the Reporting of Studies of Intravitreal Corticosteroid Therapy for Diabetic Macular Edema: A Systematic Review1177-5483https://doaj.org/article/222e39e4f468403588d1cb5193c442532020-08-01T00:00:00Zhttps://www.dovepress.com/analysis-of-funding-source-and-spin-in-the-reporting-of-studies-of-int-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Harrish Nithianandan,1 Ajay E Kuriyan,2 Michael J Venincasa,3 Jayanth Sridhar3 1Department of Ophthalmology & Visual Sciences, McGill University, Montreal, Quebec, Canada; 2Retina Service, Wills Eye Hospital, Philadelphia, PA, USA; 3Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL, USACorrespondence: Jayanth Sridhar Email jsridhar1@med.miami.eduPurpose: This systematic review examined the relationship between industry funding and the presence of spin in high-impact studies evaluating intravitreal corticosteroid therapy for diabetic macular edema.Methods: This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. MEDLINE and Embase were systematically searched from inception through July 16, 2018, for randomized controlled trials and meta-analyses investigating the treatment of patients with diabetic macular edema using intravitreal corticosteroid therapy. Only studies published in English journals with an impact factor greater than 2 as per the Clarivate Analytics 2017 Journal Citation Report were included. The authors independently assessed study quality, funding source and the presence of reporting bias using a standardized datasheet.Results: Title and abstract screening were completed on 7158 unique hits and full-text review yielded 44 included studies. Overall, there was correspondence between the wording of abstract conclusions and study results in 41/44 (93%) articles. Correspondence between abstract conclusions and significance of main outcome was present in 14/14 (100%) industry-funded and 27/30 (90%) nonindustry-funded studies. The odds ratio of industry funding being associated with noncorrespondence was 0.27 (95% CI: 0.01– 5.61, p=0.54). The most common reason for noncorrespondence was the failure to mention rates of steroid-related intraocular pressure elevation.Conclusion: The results of this systematic review indicate that biased abstract outcome reporting is rare in published randomized controlled trials and meta-analyses of intravitreal corticosteroid therapy for diabetic macular edema. Biased reporting was not associated with the presence of industry funding or a conflict of interest.Keywords: corticosteroids, diabetic retinopathy, intravitreal therapy, macular edema, systematic reviewNithianandan HKuriyan AEVenincasa MJSridhar JDove Medical Pressarticlecorticosteroidsdiabetic retinopathyintravitreal therapymacular edemasystematic reviewOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 2383-2395 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	corticosteroids diabetic retinopathy intravitreal therapy macular edema systematic review Ophthalmology RE1-994
spellingShingle	corticosteroids diabetic retinopathy intravitreal therapy macular edema systematic review Ophthalmology RE1-994 Nithianandan H Kuriyan AE Venincasa MJ Sridhar J Analysis of Funding Source and Spin in the Reporting of Studies of Intravitreal Corticosteroid Therapy for Diabetic Macular Edema: A Systematic Review
description	Harrish Nithianandan,1 Ajay E Kuriyan,2 Michael J Venincasa,3 Jayanth Sridhar3 1Department of Ophthalmology & Visual Sciences, McGill University, Montreal, Quebec, Canada; 2Retina Service, Wills Eye Hospital, Philadelphia, PA, USA; 3Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL, USACorrespondence: Jayanth Sridhar Email jsridhar1@med.miami.eduPurpose: This systematic review examined the relationship between industry funding and the presence of spin in high-impact studies evaluating intravitreal corticosteroid therapy for diabetic macular edema.Methods: This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. MEDLINE and Embase were systematically searched from inception through July 16, 2018, for randomized controlled trials and meta-analyses investigating the treatment of patients with diabetic macular edema using intravitreal corticosteroid therapy. Only studies published in English journals with an impact factor greater than 2 as per the Clarivate Analytics 2017 Journal Citation Report were included. The authors independently assessed study quality, funding source and the presence of reporting bias using a standardized datasheet.Results: Title and abstract screening were completed on 7158 unique hits and full-text review yielded 44 included studies. Overall, there was correspondence between the wording of abstract conclusions and study results in 41/44 (93%) articles. Correspondence between abstract conclusions and significance of main outcome was present in 14/14 (100%) industry-funded and 27/30 (90%) nonindustry-funded studies. The odds ratio of industry funding being associated with noncorrespondence was 0.27 (95% CI: 0.01– 5.61, p=0.54). The most common reason for noncorrespondence was the failure to mention rates of steroid-related intraocular pressure elevation.Conclusion: The results of this systematic review indicate that biased abstract outcome reporting is rare in published randomized controlled trials and meta-analyses of intravitreal corticosteroid therapy for diabetic macular edema. Biased reporting was not associated with the presence of industry funding or a conflict of interest.Keywords: corticosteroids, diabetic retinopathy, intravitreal therapy, macular edema, systematic review
format	article
author	Nithianandan H Kuriyan AE Venincasa MJ Sridhar J
author_facet	Nithianandan H Kuriyan AE Venincasa MJ Sridhar J
author_sort	Nithianandan H
title	Analysis of Funding Source and Spin in the Reporting of Studies of Intravitreal Corticosteroid Therapy for Diabetic Macular Edema: A Systematic Review
title_short	Analysis of Funding Source and Spin in the Reporting of Studies of Intravitreal Corticosteroid Therapy for Diabetic Macular Edema: A Systematic Review
title_full	Analysis of Funding Source and Spin in the Reporting of Studies of Intravitreal Corticosteroid Therapy for Diabetic Macular Edema: A Systematic Review
title_fullStr	Analysis of Funding Source and Spin in the Reporting of Studies of Intravitreal Corticosteroid Therapy for Diabetic Macular Edema: A Systematic Review
title_full_unstemmed	Analysis of Funding Source and Spin in the Reporting of Studies of Intravitreal Corticosteroid Therapy for Diabetic Macular Edema: A Systematic Review
title_sort	analysis of funding source and spin in the reporting of studies of intravitreal corticosteroid therapy for diabetic macular edema: a systematic review
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/222e39e4f468403588d1cb5193c44253
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Analysis of Funding Source and Spin in the Reporting of Studies of Intravitreal Corticosteroid Therapy for Diabetic Macular Edema: A Systematic Review

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