Ocular growth and metabolomics are dependent upon the spectral content of ambient white light

Abstract Myopia results from an excessive axial growth of the eye, causing abnormal projection of remote images in front of the retina. Without adequate interventions, myopia is forecasted to affect 50% of the world population by 2050. Exposure to outdoor light plays a critical role in preventing my...

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Autores principales:	Raymond P. Najjar, Juan Manuel Chao De La Barca, Veluchamy A. Barathi, Candice Ee Hua Ho, Jing Zhan Lock, Arumugam R. Muralidharan, Royston K. Y. Tan, Chetna Dhand, Rajamani Lakshminarayanan, Pascal Reynier, Dan Milea
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/222e56a623944021b7463a46819fb025
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spelling	oai:doaj.org-article:222e56a623944021b7463a46819fb0252021-12-02T14:25:55ZOcular growth and metabolomics are dependent upon the spectral content of ambient white light10.1038/s41598-021-87201-22045-2322https://doaj.org/article/222e56a623944021b7463a46819fb0252021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87201-2https://doaj.org/toc/2045-2322Abstract Myopia results from an excessive axial growth of the eye, causing abnormal projection of remote images in front of the retina. Without adequate interventions, myopia is forecasted to affect 50% of the world population by 2050. Exposure to outdoor light plays a critical role in preventing myopia in children, possibly through the brightness and blue-shifted spectral composition of sunlight, which lacks in artificial indoor lighting. Here, we evaluated the impact of moderate levels of ambient standard white (SW: 233.1 lux, 3900 K) and blue-enriched white (BEW: 223.8 lux, 9700 K) lights on ocular growth and metabolomics in a chicken-model of form-deprivation myopia. Compared to SW light, BEW light decreased aberrant ocular axial elongation and accelerated recovery from form-deprivation. Furthermore, the metabolomic profiles in the vitreous and retinas of recovering form-deprived eyes were distinct from control eyes and were dependent on the spectral content of ambient light. For instance, exposure to BEW light was associated with deep lipid remodeling and metabolic changes related to energy production, cell proliferation, collagen turnover and nitric oxide metabolism. This study provides new insight on light-dependent modulations in ocular growth and metabolomics. If replicable in humans, our findings open new potential avenues for spectrally-tailored light-therapy strategies for myopia.Raymond P. NajjarJuan Manuel Chao De La BarcaVeluchamy A. BarathiCandice Ee Hua HoJing Zhan LockArumugam R. MuralidharanRoyston K. Y. TanChetna DhandRajamani LakshminarayananPascal ReynierDan MileaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Raymond P. Najjar Juan Manuel Chao De La Barca Veluchamy A. Barathi Candice Ee Hua Ho Jing Zhan Lock Arumugam R. Muralidharan Royston K. Y. Tan Chetna Dhand Rajamani Lakshminarayanan Pascal Reynier Dan Milea Ocular growth and metabolomics are dependent upon the spectral content of ambient white light
description	Abstract Myopia results from an excessive axial growth of the eye, causing abnormal projection of remote images in front of the retina. Without adequate interventions, myopia is forecasted to affect 50% of the world population by 2050. Exposure to outdoor light plays a critical role in preventing myopia in children, possibly through the brightness and blue-shifted spectral composition of sunlight, which lacks in artificial indoor lighting. Here, we evaluated the impact of moderate levels of ambient standard white (SW: 233.1 lux, 3900 K) and blue-enriched white (BEW: 223.8 lux, 9700 K) lights on ocular growth and metabolomics in a chicken-model of form-deprivation myopia. Compared to SW light, BEW light decreased aberrant ocular axial elongation and accelerated recovery from form-deprivation. Furthermore, the metabolomic profiles in the vitreous and retinas of recovering form-deprived eyes were distinct from control eyes and were dependent on the spectral content of ambient light. For instance, exposure to BEW light was associated with deep lipid remodeling and metabolic changes related to energy production, cell proliferation, collagen turnover and nitric oxide metabolism. This study provides new insight on light-dependent modulations in ocular growth and metabolomics. If replicable in humans, our findings open new potential avenues for spectrally-tailored light-therapy strategies for myopia.
format	article
author	Raymond P. Najjar Juan Manuel Chao De La Barca Veluchamy A. Barathi Candice Ee Hua Ho Jing Zhan Lock Arumugam R. Muralidharan Royston K. Y. Tan Chetna Dhand Rajamani Lakshminarayanan Pascal Reynier Dan Milea
author_facet	Raymond P. Najjar Juan Manuel Chao De La Barca Veluchamy A. Barathi Candice Ee Hua Ho Jing Zhan Lock Arumugam R. Muralidharan Royston K. Y. Tan Chetna Dhand Rajamani Lakshminarayanan Pascal Reynier Dan Milea
author_sort	Raymond P. Najjar
title	Ocular growth and metabolomics are dependent upon the spectral content of ambient white light
title_short	Ocular growth and metabolomics are dependent upon the spectral content of ambient white light
title_full	Ocular growth and metabolomics are dependent upon the spectral content of ambient white light
title_fullStr	Ocular growth and metabolomics are dependent upon the spectral content of ambient white light
title_full_unstemmed	Ocular growth and metabolomics are dependent upon the spectral content of ambient white light
title_sort	ocular growth and metabolomics are dependent upon the spectral content of ambient white light
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/222e56a623944021b7463a46819fb025
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Ocular growth and metabolomics are dependent upon the spectral content of ambient white light

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