Phosphorus(III)-assisted regioselective C–H silylation of heteroarenes

Indole C-H silylation preferentially occurs at the C3 and C2 positions, while functionalization of the benzene core (C4-C7 sites) remains challenging. Here, the authors report a regioselective C7-H silylation of indole derivatives assisted by strong coordination of the palladium catalyst with a phos...

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Auteurs principaux:	Dingyi Wang, Xiangyang Chen, Jonathan J. Wong, Liqun Jin, Mingjie Li, Yue Zhao, K. N. Houk, Zhuangzhi Shi
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/222e916433ba4e079c6a6a225c9a4b6c
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id	oai:doaj.org-article:222e916433ba4e079c6a6a225c9a4b6c
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spelling	oai:doaj.org-article:222e916433ba4e079c6a6a225c9a4b6c2021-12-02T14:19:11ZPhosphorus(III)-assisted regioselective C–H silylation of heteroarenes10.1038/s41467-020-20531-32041-1723https://doaj.org/article/222e916433ba4e079c6a6a225c9a4b6c2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20531-3https://doaj.org/toc/2041-1723Indole C-H silylation preferentially occurs at the C3 and C2 positions, while functionalization of the benzene core (C4-C7 sites) remains challenging. Here, the authors report a regioselective C7-H silylation of indole derivatives assisted by strong coordination of the palladium catalyst with a phosphorus directing group.Dingyi WangXiangyang ChenJonathan J. WongLiqun JinMingjie LiYue ZhaoK. N. HoukZhuangzhi ShiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dingyi Wang Xiangyang Chen Jonathan J. Wong Liqun Jin Mingjie Li Yue Zhao K. N. Houk Zhuangzhi Shi Phosphorus(III)-assisted regioselective C–H silylation of heteroarenes
description	Indole C-H silylation preferentially occurs at the C3 and C2 positions, while functionalization of the benzene core (C4-C7 sites) remains challenging. Here, the authors report a regioselective C7-H silylation of indole derivatives assisted by strong coordination of the palladium catalyst with a phosphorus directing group.
format	article
author	Dingyi Wang Xiangyang Chen Jonathan J. Wong Liqun Jin Mingjie Li Yue Zhao K. N. Houk Zhuangzhi Shi
author_facet	Dingyi Wang Xiangyang Chen Jonathan J. Wong Liqun Jin Mingjie Li Yue Zhao K. N. Houk Zhuangzhi Shi
author_sort	Dingyi Wang
title	Phosphorus(III)-assisted regioselective C–H silylation of heteroarenes
title_short	Phosphorus(III)-assisted regioselective C–H silylation of heteroarenes
title_full	Phosphorus(III)-assisted regioselective C–H silylation of heteroarenes
title_fullStr	Phosphorus(III)-assisted regioselective C–H silylation of heteroarenes
title_full_unstemmed	Phosphorus(III)-assisted regioselective C–H silylation of heteroarenes
title_sort	phosphorus(iii)-assisted regioselective c–h silylation of heteroarenes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/222e916433ba4e079c6a6a225c9a4b6c
work_keys_str_mv	AT dingyiwang phosphorusiiiassistedregioselectivechsilylationofheteroarenes AT xiangyangchen phosphorusiiiassistedregioselectivechsilylationofheteroarenes AT jonathanjwong phosphorusiiiassistedregioselectivechsilylationofheteroarenes AT liqunjin phosphorusiiiassistedregioselectivechsilylationofheteroarenes AT mingjieli phosphorusiiiassistedregioselectivechsilylationofheteroarenes AT yuezhao phosphorusiiiassistedregioselectivechsilylationofheteroarenes AT knhouk phosphorusiiiassistedregioselectivechsilylationofheteroarenes AT zhuangzhishi phosphorusiiiassistedregioselectivechsilylationofheteroarenes
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Phosphorus(III)-assisted regioselective C–H silylation of heteroarenes

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