Phosphorus(III)-assisted regioselective C–H silylation of heteroarenes

Indole C-H silylation preferentially occurs at the C3 and C2 positions, while functionalization of the benzene core (C4-C7 sites) remains challenging. Here, the authors report a regioselective C7-H silylation of indole derivatives assisted by strong coordination of the palladium catalyst with a phos...

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Bibliographic Details
Main Authors: Dingyi Wang, Xiangyang Chen, Jonathan J. Wong, Liqun Jin, Mingjie Li, Yue Zhao, K. N. Houk, Zhuangzhi Shi
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/222e916433ba4e079c6a6a225c9a4b6c
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