Controlled Release of Tazarotene from Magnetically Responsive Nanofiber Patch: Towards More Efficient Topical Therapy of Psoriasis

Electrospun polycaprolactone nanofibers with embedded magnetic nanoparticles were developed for use in the topical delivery of antipsoriatic drugs. To test a hydrophobic drug, a tazarotene has been used, which is an efficient retinoid derivative. Such a smart hyperthermia nanofiber system with self-...

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Autores principales:	Natália Andrýsková, Paul Sourivong, Melánia Babincová, Mária Šimaljaková
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	psoriasis tazarotene topical application drug delivery systems nanofiber patch magnetic nanoparticles Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/2230ca5ec7094607a43fdb9daf8bd1ae
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spelling	oai:doaj.org-article:2230ca5ec7094607a43fdb9daf8bd1ae2021-11-25T16:43:00ZControlled Release of Tazarotene from Magnetically Responsive Nanofiber Patch: Towards More Efficient Topical Therapy of Psoriasis10.3390/app1122110222076-3417https://doaj.org/article/2230ca5ec7094607a43fdb9daf8bd1ae2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/22/11022https://doaj.org/toc/2076-3417Electrospun polycaprolactone nanofibers with embedded magnetic nanoparticles were developed for use in the topical delivery of antipsoriatic drugs. To test a hydrophobic drug, a tazarotene has been used, which is an efficient retinoid derivative. Such a smart hyperthermia nanofiber system with self-generated heat from the incorporated magnetic nanoparticles induced drug release in response to on–off switching of alternating magnetic fields for the delivery of tazarotene through the skin, as quantified using Franz cells. This highly efficient external field-controllable system with minimal skin irritation could create a new avenue for the topical therapy of psoriasis.Natália AndrýskováPaul SourivongMelánia BabincováMária ŠimaljakováMDPI AGarticlepsoriasistazarotenetopical applicationdrug delivery systemsnanofiber patchmagnetic nanoparticlesTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 11022, p 11022 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	psoriasis tazarotene topical application drug delivery systems nanofiber patch magnetic nanoparticles Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	psoriasis tazarotene topical application drug delivery systems nanofiber patch magnetic nanoparticles Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Natália Andrýsková Paul Sourivong Melánia Babincová Mária Šimaljaková Controlled Release of Tazarotene from Magnetically Responsive Nanofiber Patch: Towards More Efficient Topical Therapy of Psoriasis
description	Electrospun polycaprolactone nanofibers with embedded magnetic nanoparticles were developed for use in the topical delivery of antipsoriatic drugs. To test a hydrophobic drug, a tazarotene has been used, which is an efficient retinoid derivative. Such a smart hyperthermia nanofiber system with self-generated heat from the incorporated magnetic nanoparticles induced drug release in response to on–off switching of alternating magnetic fields for the delivery of tazarotene through the skin, as quantified using Franz cells. This highly efficient external field-controllable system with minimal skin irritation could create a new avenue for the topical therapy of psoriasis.
format	article
author	Natália Andrýsková Paul Sourivong Melánia Babincová Mária Šimaljaková
author_facet	Natália Andrýsková Paul Sourivong Melánia Babincová Mária Šimaljaková
author_sort	Natália Andrýsková
title	Controlled Release of Tazarotene from Magnetically Responsive Nanofiber Patch: Towards More Efficient Topical Therapy of Psoriasis
title_short	Controlled Release of Tazarotene from Magnetically Responsive Nanofiber Patch: Towards More Efficient Topical Therapy of Psoriasis
title_full	Controlled Release of Tazarotene from Magnetically Responsive Nanofiber Patch: Towards More Efficient Topical Therapy of Psoriasis
title_fullStr	Controlled Release of Tazarotene from Magnetically Responsive Nanofiber Patch: Towards More Efficient Topical Therapy of Psoriasis
title_full_unstemmed	Controlled Release of Tazarotene from Magnetically Responsive Nanofiber Patch: Towards More Efficient Topical Therapy of Psoriasis
title_sort	controlled release of tazarotene from magnetically responsive nanofiber patch: towards more efficient topical therapy of psoriasis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2230ca5ec7094607a43fdb9daf8bd1ae
work_keys_str_mv	AT nataliaandryskova controlledreleaseoftazarotenefrommagneticallyresponsivenanofiberpatchtowardsmoreefficienttopicaltherapyofpsoriasis AT paulsourivong controlledreleaseoftazarotenefrommagneticallyresponsivenanofiberpatchtowardsmoreefficienttopicaltherapyofpsoriasis AT melaniababincova controlledreleaseoftazarotenefrommagneticallyresponsivenanofiberpatchtowardsmoreefficienttopicaltherapyofpsoriasis AT mariasimaljakova controlledreleaseoftazarotenefrommagneticallyresponsivenanofiberpatchtowardsmoreefficienttopicaltherapyofpsoriasis
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Controlled Release of Tazarotene from Magnetically Responsive Nanofiber Patch: Towards More Efficient Topical Therapy of Psoriasis

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