The COVID-19 Pandemic Affects Male Patients With Chronic Spontaneous Urticaria More Than Female Patients

IntroductionThe COVID-19 pandemic dramatically disrupts health care for patients with chronic diseases including chronic spontaneous urticaria (CSU). As of now, it is unknown if the effects of the pandemic in CSU are different than in other chronic diseases. We also do not know, if different groups...

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Autores principales:	Huzeyfe Kulu, Mustafa Atasoy, Kemal Özyurt, Marcus Maurer, Atıl Avcı, Muhammet Reşat Akkuş, Ragıp Ertaş
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	chronic spontaneous urticaria chronic skin diseases COVID-19 psoriasis pandemic (COVID19) Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/2235f84cafb444e08816173bda9b54e6
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spelling	oai:doaj.org-article:2235f84cafb444e08816173bda9b54e62021-11-04T11:44:21ZThe COVID-19 Pandemic Affects Male Patients With Chronic Spontaneous Urticaria More Than Female Patients1664-322410.3389/fimmu.2021.722406https://doaj.org/article/2235f84cafb444e08816173bda9b54e62021-10-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.722406/fullhttps://doaj.org/toc/1664-3224IntroductionThe COVID-19 pandemic dramatically disrupts health care for patients with chronic diseases including chronic spontaneous urticaria (CSU). As of now, it is unknown if the effects of the pandemic in CSU are different than in other chronic diseases. We also do not know, if different groups of CSU patients, for example female and male patients, are affected differently.AimTo understand how CSU patients and subgroups are affected by the COVID-19 pandemic in their disease activity and control and treatment, using psoriasis as control.Patients and MethodsWe analyzed 399 patients (450 visits) with CSU or psoriasis assessed during August 2019, i.e. before the pandemic, or August 2020, i.e. during the pandemic, for changes in disease activity, disease control, and the treatment they used, and how these changes are linked to age, gender, and disease duration.ResultsMale but not female patients with CSU had markedly increased disease activity during the pandemic. CSU patients’ age or disease duration were not linked to changes. Male and female patients with psoriasis showed similar increases in disease activity and decreases in disease control. The rate of omalizumab treatment, during the pandemic, was unchanged in male patients and increased in female patients with CSU. The efficacy of omalizumab treatment, during the pandemic, was reduced in male patients but not female patients with CSU.ConclusionMale but not female CSU patients, during the COVID-19 pandemic, show loss of disease control linked to loss of omalizumab efficacy. The reasons for this need to be investigated.Huzeyfe KuluMustafa AtasoyKemal ÖzyurtMarcus MaurerAtıl AvcıMuhammet Reşat AkkuşRagıp ErtaşFrontiers Media S.A.articlechronic spontaneous urticariachronic skin diseasesCOVID-19psoriasispandemic (COVID19)Immunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic spontaneous urticaria chronic skin diseases COVID-19 psoriasis pandemic (COVID19) Immunologic diseases. Allergy RC581-607
spellingShingle	chronic spontaneous urticaria chronic skin diseases COVID-19 psoriasis pandemic (COVID19) Immunologic diseases. Allergy RC581-607 Huzeyfe Kulu Mustafa Atasoy Kemal Özyurt Marcus Maurer Atıl Avcı Muhammet Reşat Akkuş Ragıp Ertaş The COVID-19 Pandemic Affects Male Patients With Chronic Spontaneous Urticaria More Than Female Patients
description	IntroductionThe COVID-19 pandemic dramatically disrupts health care for patients with chronic diseases including chronic spontaneous urticaria (CSU). As of now, it is unknown if the effects of the pandemic in CSU are different than in other chronic diseases. We also do not know, if different groups of CSU patients, for example female and male patients, are affected differently.AimTo understand how CSU patients and subgroups are affected by the COVID-19 pandemic in their disease activity and control and treatment, using psoriasis as control.Patients and MethodsWe analyzed 399 patients (450 visits) with CSU or psoriasis assessed during August 2019, i.e. before the pandemic, or August 2020, i.e. during the pandemic, for changes in disease activity, disease control, and the treatment they used, and how these changes are linked to age, gender, and disease duration.ResultsMale but not female patients with CSU had markedly increased disease activity during the pandemic. CSU patients’ age or disease duration were not linked to changes. Male and female patients with psoriasis showed similar increases in disease activity and decreases in disease control. The rate of omalizumab treatment, during the pandemic, was unchanged in male patients and increased in female patients with CSU. The efficacy of omalizumab treatment, during the pandemic, was reduced in male patients but not female patients with CSU.ConclusionMale but not female CSU patients, during the COVID-19 pandemic, show loss of disease control linked to loss of omalizumab efficacy. The reasons for this need to be investigated.
format	article
author	Huzeyfe Kulu Mustafa Atasoy Kemal Özyurt Marcus Maurer Atıl Avcı Muhammet Reşat Akkuş Ragıp Ertaş
author_facet	Huzeyfe Kulu Mustafa Atasoy Kemal Özyurt Marcus Maurer Atıl Avcı Muhammet Reşat Akkuş Ragıp Ertaş
author_sort	Huzeyfe Kulu
title	The COVID-19 Pandemic Affects Male Patients With Chronic Spontaneous Urticaria More Than Female Patients
title_short	The COVID-19 Pandemic Affects Male Patients With Chronic Spontaneous Urticaria More Than Female Patients
title_full	The COVID-19 Pandemic Affects Male Patients With Chronic Spontaneous Urticaria More Than Female Patients
title_fullStr	The COVID-19 Pandemic Affects Male Patients With Chronic Spontaneous Urticaria More Than Female Patients
title_full_unstemmed	The COVID-19 Pandemic Affects Male Patients With Chronic Spontaneous Urticaria More Than Female Patients
title_sort	covid-19 pandemic affects male patients with chronic spontaneous urticaria more than female patients
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/2235f84cafb444e08816173bda9b54e6
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The COVID-19 Pandemic Affects Male Patients With Chronic Spontaneous Urticaria More Than Female Patients

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