Genetic and Enzymatic Characteristics of CYP2A13 in Relation to Lung Damage

Cytochrome P450 2A13 is an omitted brother of CYP2A6 that has an important role in the drug metabolism of liver. Due to extrahepatic expression, it has gained less attention than CYP2A6, despite the fact that it plays a significant role in toxicant-induced pulmonary lesions and, therefore, lung canc...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Radim Vrzal
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	lung cancer skatole NNK aflatoxin polymorphism regulation Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/22382394ee334fbdbe9e1f974397f9ec
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:22382394ee334fbdbe9e1f974397f9ec
record_format	dspace
spelling	oai:doaj.org-article:22382394ee334fbdbe9e1f974397f9ec2021-11-25T17:55:16ZGenetic and Enzymatic Characteristics of CYP2A13 in Relation to Lung Damage10.3390/ijms2222123061422-00671661-6596https://doaj.org/article/22382394ee334fbdbe9e1f974397f9ec2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12306https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Cytochrome P450 2A13 is an omitted brother of CYP2A6 that has an important role in the drug metabolism of liver. Due to extrahepatic expression, it has gained less attention than CYP2A6, despite the fact that it plays a significant role in toxicant-induced pulmonary lesions and, therefore, lung cancer. The purpose of this mini-review is to summarize the basic knowledge about this enzyme in relation to the substrates, inhibitors, genetic polymorphisms, and transcriptional regulation that are known so far (September 2021).Radim VrzalMDPI AGarticlelung cancerskatoleNNKaflatoxinpolymorphismregulationBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12306, p 12306 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lung cancer skatole NNK aflatoxin polymorphism regulation Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	lung cancer skatole NNK aflatoxin polymorphism regulation Biology (General) QH301-705.5 Chemistry QD1-999 Radim Vrzal Genetic and Enzymatic Characteristics of CYP2A13 in Relation to Lung Damage
description	Cytochrome P450 2A13 is an omitted brother of CYP2A6 that has an important role in the drug metabolism of liver. Due to extrahepatic expression, it has gained less attention than CYP2A6, despite the fact that it plays a significant role in toxicant-induced pulmonary lesions and, therefore, lung cancer. The purpose of this mini-review is to summarize the basic knowledge about this enzyme in relation to the substrates, inhibitors, genetic polymorphisms, and transcriptional regulation that are known so far (September 2021).
format	article
author	Radim Vrzal
author_facet	Radim Vrzal
author_sort	Radim Vrzal
title	Genetic and Enzymatic Characteristics of CYP2A13 in Relation to Lung Damage
title_short	Genetic and Enzymatic Characteristics of CYP2A13 in Relation to Lung Damage
title_full	Genetic and Enzymatic Characteristics of CYP2A13 in Relation to Lung Damage
title_fullStr	Genetic and Enzymatic Characteristics of CYP2A13 in Relation to Lung Damage
title_full_unstemmed	Genetic and Enzymatic Characteristics of CYP2A13 in Relation to Lung Damage
title_sort	genetic and enzymatic characteristics of cyp2a13 in relation to lung damage
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/22382394ee334fbdbe9e1f974397f9ec
work_keys_str_mv	AT radimvrzal geneticandenzymaticcharacteristicsofcyp2a13inrelationtolungdamage
_version_	1718411850848141312

Genetic and Enzymatic Characteristics of CYP2A13 in Relation to Lung Damage

Ejemplares similares