CONTENTS OF SERUM MYELIN BASIC PROTEIN-IGG ANTIBODIES COMPLEXES IN NORMAL PREGNANCY AND GESTOSIS

Serum levels of myelin basic protein (MBP)-bound immune complexes were studied in blood sera from women with gestosis, as compared with those in normal pregnancy and non-pregnant woman. The amounts of IgG-MBP complex in blood serum were determined by enzyme immunoassay using isolated anti-МBP-antibo...

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Autores principales:	V. G. Levchenko, N. V. Maltseva, O. F. Lykova, T. V. Konysheva, V. N. Zorina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	basic myelin protein immune complexes pregnancy Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/223847a1bf6f4fa5abded31be5f99fa3
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spelling	oai:doaj.org-article:223847a1bf6f4fa5abded31be5f99fa32021-11-18T08:03:37ZCONTENTS OF SERUM MYELIN BASIC PROTEIN-IGG ANTIBODIES COMPLEXES IN NORMAL PREGNANCY AND GESTOSIS1563-06252313-741X10.15789/1563-0625-2010-1-2-155-160https://doaj.org/article/223847a1bf6f4fa5abded31be5f99fa32014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/63https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XSerum levels of myelin basic protein (MBP)-bound immune complexes were studied in blood sera from women with gestosis, as compared with those in normal pregnancy and non-pregnant woman. The amounts of IgG-MBP complex in blood serum were determined by enzyme immunoassay using isolated anti-МBP-antibodies. The study has shown that about 0.05 mcg of IgG ml of blood serum are associated with myelin basic protein in unpregnant women or in normal pregnancy. Mild gestosis is accompanied by a 2-3-fold increase in MBP immunocomplex concentrations in blood serum. More severe stages of gestosis are characterized by its further rise, thus achieving maximal values of such MBP immune complexes (0.8 mcg/ml) in patients with pre-eclampsia and eclampsia. Their amounts were reduced twice after the periods of eclampsia. Serum levels of MBP-bound IgGs may be used to determine severity of gestosis and to predict a risk of eclampsia in pregnant women.V. G. LevchenkoN. V. MaltsevaO. F. LykovaT. V. KonyshevaV. N. ZorinaSPb RAACIarticlebasic myelin proteinimmune complexespregnancyImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 1-2, Pp 155-160 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	basic myelin protein immune complexes pregnancy Immunologic diseases. Allergy RC581-607
spellingShingle	basic myelin protein immune complexes pregnancy Immunologic diseases. Allergy RC581-607 V. G. Levchenko N. V. Maltseva O. F. Lykova T. V. Konysheva V. N. Zorina CONTENTS OF SERUM MYELIN BASIC PROTEIN-IGG ANTIBODIES COMPLEXES IN NORMAL PREGNANCY AND GESTOSIS
description	Serum levels of myelin basic protein (MBP)-bound immune complexes were studied in blood sera from women with gestosis, as compared with those in normal pregnancy and non-pregnant woman. The amounts of IgG-MBP complex in blood serum were determined by enzyme immunoassay using isolated anti-МBP-antibodies. The study has shown that about 0.05 mcg of IgG ml of blood serum are associated with myelin basic protein in unpregnant women or in normal pregnancy. Mild gestosis is accompanied by a 2-3-fold increase in MBP immunocomplex concentrations in blood serum. More severe stages of gestosis are characterized by its further rise, thus achieving maximal values of such MBP immune complexes (0.8 mcg/ml) in patients with pre-eclampsia and eclampsia. Their amounts were reduced twice after the periods of eclampsia. Serum levels of MBP-bound IgGs may be used to determine severity of gestosis and to predict a risk of eclampsia in pregnant women.
format	article
author	V. G. Levchenko N. V. Maltseva O. F. Lykova T. V. Konysheva V. N. Zorina
author_facet	V. G. Levchenko N. V. Maltseva O. F. Lykova T. V. Konysheva V. N. Zorina
author_sort	V. G. Levchenko
title	CONTENTS OF SERUM MYELIN BASIC PROTEIN-IGG ANTIBODIES COMPLEXES IN NORMAL PREGNANCY AND GESTOSIS
title_short	CONTENTS OF SERUM MYELIN BASIC PROTEIN-IGG ANTIBODIES COMPLEXES IN NORMAL PREGNANCY AND GESTOSIS
title_full	CONTENTS OF SERUM MYELIN BASIC PROTEIN-IGG ANTIBODIES COMPLEXES IN NORMAL PREGNANCY AND GESTOSIS
title_fullStr	CONTENTS OF SERUM MYELIN BASIC PROTEIN-IGG ANTIBODIES COMPLEXES IN NORMAL PREGNANCY AND GESTOSIS
title_full_unstemmed	CONTENTS OF SERUM MYELIN BASIC PROTEIN-IGG ANTIBODIES COMPLEXES IN NORMAL PREGNANCY AND GESTOSIS
title_sort	contents of serum myelin basic protein-igg antibodies complexes in normal pregnancy and gestosis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/223847a1bf6f4fa5abded31be5f99fa3
work_keys_str_mv	AT vglevchenko contentsofserummyelinbasicproteiniggantibodiescomplexesinnormalpregnancyandgestosis AT nvmaltseva contentsofserummyelinbasicproteiniggantibodiescomplexesinnormalpregnancyandgestosis AT oflykova contentsofserummyelinbasicproteiniggantibodiescomplexesinnormalpregnancyandgestosis AT tvkonysheva contentsofserummyelinbasicproteiniggantibodiescomplexesinnormalpregnancyandgestosis AT vnzorina contentsofserummyelinbasicproteiniggantibodiescomplexesinnormalpregnancyandgestosis
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CONTENTS OF SERUM MYELIN BASIC PROTEIN-IGG ANTIBODIES COMPLEXES IN NORMAL PREGNANCY AND GESTOSIS

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