Seroepidemiology of Dengue virus in Mayotte, Indian Ocean, 2006.

<h4>Background</h4>Although Dengue virus (DENV) circulation had been documented in neighbouring South-western Indian Ocean Islands, its presence in Mayotte is poorly characterised. To address this issue, we aimed to assess the seroprevalence of dengue IgG antibodies (DENV-IgG Ab) among t...

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Autores principales:	Daouda Sissoko, Khaled Ezzedine, Claude Giry, Amrat Moendandzé, Tinne Lernout, Eric D'Ortenzio, François Pettinelli, Denis Malvy
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/223a923432084277ad1f7b9e763d9915
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spelling	oai:doaj.org-article:223a923432084277ad1f7b9e763d99152021-11-18T07:02:13ZSeroepidemiology of Dengue virus in Mayotte, Indian Ocean, 2006.1932-620310.1371/journal.pone.0014141https://doaj.org/article/223a923432084277ad1f7b9e763d99152010-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21152441/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Although Dengue virus (DENV) circulation had been documented in neighbouring South-western Indian Ocean Islands, its presence in Mayotte is poorly characterised. To address this issue, we aimed to assess the seroprevalence of dengue IgG antibodies (DENV-IgG Ab) among the population and to investigate potential associations with individual and household characteristics.<h4>Methods/principal findings</h4>In November-December 2006 we conducted a cross-sectional serologic survey in Mayotte among 1,154 inhabitants aged≥2 years by using a multistage cluster random sampling method. The overall prevalence of DENV-specific IgG antibodies (ELISA) was 22.73% (95% CI, 18.16-27.31). The age-specific seroprevalence increased with age (χ2 for trend=11.86, P<0.0006), and was linked with previous known outbreaks in this region. In multivariate analysis, older age, being born in the Comoros and living in a household with a low socioeconomic index were positively associated with DENV IgG antibody positivity.<h4>Conclusions</h4>These findings document substantial prior exposure of the population of Mayotte to DENV and highlight the risk of severe illness due to the possibility of sequential DENV infections. Further investigations characterizing current DENV circulation patterns and associated serotypes are needed.Daouda SissokoKhaled EzzedineClaude GiryAmrat MoendandzéTinne LernoutEric D'OrtenzioFrançois PettinelliDenis MalvyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 11, p e14141 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daouda Sissoko Khaled Ezzedine Claude Giry Amrat Moendandzé Tinne Lernout Eric D'Ortenzio François Pettinelli Denis Malvy Seroepidemiology of Dengue virus in Mayotte, Indian Ocean, 2006.
description	<h4>Background</h4>Although Dengue virus (DENV) circulation had been documented in neighbouring South-western Indian Ocean Islands, its presence in Mayotte is poorly characterised. To address this issue, we aimed to assess the seroprevalence of dengue IgG antibodies (DENV-IgG Ab) among the population and to investigate potential associations with individual and household characteristics.<h4>Methods/principal findings</h4>In November-December 2006 we conducted a cross-sectional serologic survey in Mayotte among 1,154 inhabitants aged≥2 years by using a multistage cluster random sampling method. The overall prevalence of DENV-specific IgG antibodies (ELISA) was 22.73% (95% CI, 18.16-27.31). The age-specific seroprevalence increased with age (χ2 for trend=11.86, P<0.0006), and was linked with previous known outbreaks in this region. In multivariate analysis, older age, being born in the Comoros and living in a household with a low socioeconomic index were positively associated with DENV IgG antibody positivity.<h4>Conclusions</h4>These findings document substantial prior exposure of the population of Mayotte to DENV and highlight the risk of severe illness due to the possibility of sequential DENV infections. Further investigations characterizing current DENV circulation patterns and associated serotypes are needed.
format	article
author	Daouda Sissoko Khaled Ezzedine Claude Giry Amrat Moendandzé Tinne Lernout Eric D'Ortenzio François Pettinelli Denis Malvy
author_facet	Daouda Sissoko Khaled Ezzedine Claude Giry Amrat Moendandzé Tinne Lernout Eric D'Ortenzio François Pettinelli Denis Malvy
author_sort	Daouda Sissoko
title	Seroepidemiology of Dengue virus in Mayotte, Indian Ocean, 2006.
title_short	Seroepidemiology of Dengue virus in Mayotte, Indian Ocean, 2006.
title_full	Seroepidemiology of Dengue virus in Mayotte, Indian Ocean, 2006.
title_fullStr	Seroepidemiology of Dengue virus in Mayotte, Indian Ocean, 2006.
title_full_unstemmed	Seroepidemiology of Dengue virus in Mayotte, Indian Ocean, 2006.
title_sort	seroepidemiology of dengue virus in mayotte, indian ocean, 2006.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/223a923432084277ad1f7b9e763d9915
work_keys_str_mv	AT daoudasissoko seroepidemiologyofdenguevirusinmayotteindianocean2006 AT khaledezzedine seroepidemiologyofdenguevirusinmayotteindianocean2006 AT claudegiry seroepidemiologyofdenguevirusinmayotteindianocean2006 AT amratmoendandze seroepidemiologyofdenguevirusinmayotteindianocean2006 AT tinnelernout seroepidemiologyofdenguevirusinmayotteindianocean2006 AT ericdortenzio seroepidemiologyofdenguevirusinmayotteindianocean2006 AT francoispettinelli seroepidemiologyofdenguevirusinmayotteindianocean2006 AT denismalvy seroepidemiologyofdenguevirusinmayotteindianocean2006
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Seroepidemiology of Dengue virus in Mayotte, Indian Ocean, 2006.

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