Loss of peroxiredoxin-2 exacerbates eccentric contraction-induced force loss in dystrophin-deficient muscle

In the mdx mouse model of Duchenne muscular dystrophy, muscle contractions lead to force loss, which is attributed to myofibre damage. Here, the authors show that force loss is instead mediated by a redox circuit involving NOX2, PROX1, myoglobin and cytoplasmic actins, and suggest that it may be a p...

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Auteurs principaux:	John T. Olthoff, Angus Lindsay, Reem Abo-Zahrah, Kristen A. Baltgalvis, Xiaobai Patrinostro, Joseph J. Belanto, Dae-Yeul Yu, Benjamin J. Perrin, Daniel J. Garry, George G. Rodney, Dawn A. Lowe, James M. Ervasti
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/223d776794074fb79b1d4e9d6b3d3b4f
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spelling	oai:doaj.org-article:223d776794074fb79b1d4e9d6b3d3b4f2021-12-02T14:39:26ZLoss of peroxiredoxin-2 exacerbates eccentric contraction-induced force loss in dystrophin-deficient muscle10.1038/s41467-018-07639-32041-1723https://doaj.org/article/223d776794074fb79b1d4e9d6b3d3b4f2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07639-3https://doaj.org/toc/2041-1723In the mdx mouse model of Duchenne muscular dystrophy, muscle contractions lead to force loss, which is attributed to myofibre damage. Here, the authors show that force loss is instead mediated by a redox circuit involving NOX2, PROX1, myoglobin and cytoplasmic actins, and suggest that it may be a protective mechanism to prevent excessive contraction-induced myofibre damage.John T. OlthoffAngus LindsayReem Abo-ZahrahKristen A. BaltgalvisXiaobai PatrinostroJoseph J. BelantoDae-Yeul YuBenjamin J. PerrinDaniel J. GarryGeorge G. RodneyDawn A. LoweJames M. ErvastiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q John T. Olthoff Angus Lindsay Reem Abo-Zahrah Kristen A. Baltgalvis Xiaobai Patrinostro Joseph J. Belanto Dae-Yeul Yu Benjamin J. Perrin Daniel J. Garry George G. Rodney Dawn A. Lowe James M. Ervasti Loss of peroxiredoxin-2 exacerbates eccentric contraction-induced force loss in dystrophin-deficient muscle
description	In the mdx mouse model of Duchenne muscular dystrophy, muscle contractions lead to force loss, which is attributed to myofibre damage. Here, the authors show that force loss is instead mediated by a redox circuit involving NOX2, PROX1, myoglobin and cytoplasmic actins, and suggest that it may be a protective mechanism to prevent excessive contraction-induced myofibre damage.
format	article
author	John T. Olthoff Angus Lindsay Reem Abo-Zahrah Kristen A. Baltgalvis Xiaobai Patrinostro Joseph J. Belanto Dae-Yeul Yu Benjamin J. Perrin Daniel J. Garry George G. Rodney Dawn A. Lowe James M. Ervasti
author_facet	John T. Olthoff Angus Lindsay Reem Abo-Zahrah Kristen A. Baltgalvis Xiaobai Patrinostro Joseph J. Belanto Dae-Yeul Yu Benjamin J. Perrin Daniel J. Garry George G. Rodney Dawn A. Lowe James M. Ervasti
author_sort	John T. Olthoff
title	Loss of peroxiredoxin-2 exacerbates eccentric contraction-induced force loss in dystrophin-deficient muscle
title_short	Loss of peroxiredoxin-2 exacerbates eccentric contraction-induced force loss in dystrophin-deficient muscle
title_full	Loss of peroxiredoxin-2 exacerbates eccentric contraction-induced force loss in dystrophin-deficient muscle
title_fullStr	Loss of peroxiredoxin-2 exacerbates eccentric contraction-induced force loss in dystrophin-deficient muscle
title_full_unstemmed	Loss of peroxiredoxin-2 exacerbates eccentric contraction-induced force loss in dystrophin-deficient muscle
title_sort	loss of peroxiredoxin-2 exacerbates eccentric contraction-induced force loss in dystrophin-deficient muscle
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/223d776794074fb79b1d4e9d6b3d3b4f
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Loss of peroxiredoxin-2 exacerbates eccentric contraction-induced force loss in dystrophin-deficient muscle

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