Whi5 phosphorylation embedded in the G1/S network dynamically controls critical cell size and cell fate

In budding yeast the G1/S transition requires the attainment of a critical cell size. Here the authors unravel its basic control mechanism by integrating simulations of a mathematical model of multisite phosphorylation of Whi5 by Cln3–Cdk1, with molecular analyses of a Whi5 phospho-mimetic mutant.

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Autores principales:	Pasquale Palumbo, Marco Vanoni, Valerio Cusimano, Stefano Busti, Francesca Marano, Costanzo Manes, Lilia Alberghina
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2240802c65824c75adef5680efa06b5b
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spelling	oai:doaj.org-article:2240802c65824c75adef5680efa06b5b2021-12-02T16:57:49ZWhi5 phosphorylation embedded in the G1/S network dynamically controls critical cell size and cell fate10.1038/ncomms113722041-1723https://doaj.org/article/2240802c65824c75adef5680efa06b5b2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11372https://doaj.org/toc/2041-1723In budding yeast the G1/S transition requires the attainment of a critical cell size. Here the authors unravel its basic control mechanism by integrating simulations of a mathematical model of multisite phosphorylation of Whi5 by Cln3–Cdk1, with molecular analyses of a Whi5 phospho-mimetic mutant.Pasquale PalumboMarco VanoniValerio CusimanoStefano BustiFrancesca MaranoCostanzo ManesLilia AlberghinaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pasquale Palumbo Marco Vanoni Valerio Cusimano Stefano Busti Francesca Marano Costanzo Manes Lilia Alberghina Whi5 phosphorylation embedded in the G1/S network dynamically controls critical cell size and cell fate
description	In budding yeast the G1/S transition requires the attainment of a critical cell size. Here the authors unravel its basic control mechanism by integrating simulations of a mathematical model of multisite phosphorylation of Whi5 by Cln3–Cdk1, with molecular analyses of a Whi5 phospho-mimetic mutant.
format	article
author	Pasquale Palumbo Marco Vanoni Valerio Cusimano Stefano Busti Francesca Marano Costanzo Manes Lilia Alberghina
author_facet	Pasquale Palumbo Marco Vanoni Valerio Cusimano Stefano Busti Francesca Marano Costanzo Manes Lilia Alberghina
author_sort	Pasquale Palumbo
title	Whi5 phosphorylation embedded in the G1/S network dynamically controls critical cell size and cell fate
title_short	Whi5 phosphorylation embedded in the G1/S network dynamically controls critical cell size and cell fate
title_full	Whi5 phosphorylation embedded in the G1/S network dynamically controls critical cell size and cell fate
title_fullStr	Whi5 phosphorylation embedded in the G1/S network dynamically controls critical cell size and cell fate
title_full_unstemmed	Whi5 phosphorylation embedded in the G1/S network dynamically controls critical cell size and cell fate
title_sort	whi5 phosphorylation embedded in the g1/s network dynamically controls critical cell size and cell fate
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/2240802c65824c75adef5680efa06b5b
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Whi5 phosphorylation embedded in the G1/S network dynamically controls critical cell size and cell fate

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